Fetal Origin of Childhood Disease

Shankaran, Seetha; Das, Abhik; Bauer, Charles R.; Bada, Henrietta S.; Lester, Barry M.; Wright, Linda L.; Higgins, Rosemary D.; Poole, Kenneth

doi:10.1001/archpedi.160.9.977

Cited by 67 publications

(33 citation statements)

References 33 publications

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“…Shankaran et al [17] demonstrated a tight relationship between some maternal (smoke habits during pregnancy, alcohol intake, drug-addiction, etc.) and neonatal (birth weight, gender, etc.)…”

Section: Discussionmentioning

confidence: 99%

Aorta Structural Alterations in Term Neonates: The Role of Birth and Maternal Characteristics

Ciccone

Scicchitano

Salerno

et al. 2013

BioMed Research International

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Aim. To evaluate the influence of selected maternal and neonatal characteristics on aorta walls in term, appropriately grown-for-gestational age newborns. Methods. Age, parity, previous abortions, weight, height, body mass index before and after delivery, smoking, and history of hypertension, of diabetes, of cardiovascular diseases, and of dyslipidemia were all assessed in seventy mothers. They delivered 34 males and 36 females healthy term newborns who underwent ultrasound evaluation of the anteroposterior infrarenal abdominal aorta diameter (APAO), biochemical profile (glucose, insulin, total cholesterol, HDL and LDL cholesterol, triglycerides, fibrinogen, and D-dimers homeostasis model assessment [HOMAIR]index), and biometric parameters. Results. APAO was related to newborn length (r = +0.36; P = 0.001), head circumference (r = +0.37; P = 0.001), gestational age (r = +0.40, P = 0.0005), HOMA index (r = +0.24; P = 0.04), and D-dimers (r = +0.33, P = 0.004). Smoke influenced APAO values (odds ratio: 1.80; confidence interval 95%: 1.05–3.30), as well as diabetes during pregnancy (r = +0.42, P = 0.0002). Maternal height influenced neonatal APAO (r = +0.47, P = 0.00003). Multiple regression analysis outlined neonatal D-dimers as still significantly related to neonatal APAO values. Conclusions. Many maternal and neonatal characteristics could influence aorta structures. Neonatal D-dimers are independently related to APAO.

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Section: Discussionmentioning

confidence: 99%

Aorta Structural Alterations in Term Neonates: The Role of Birth and Maternal Characteristics

Ciccone

Scicchitano

Salerno

et al. 2013

BioMed Research International

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“…The latent period after which birth size and early growth have an impact on BP also differs in the populations studied around the world. Thus, an inverse relationship between birth size and BP has been reported during adolescence (USA [10]; Philippines [46]; Brazil [47]; UK [47]), school age (age 6 years, USA [48]; age 7 years, USA [49]) and as early as age 3 years (South Korea [42,50]). These studies highlight the importance of ethnic background on early life programming and later cardiovascular morbidity.…”

Section: Discussionmentioning

confidence: 99%

Circulating Insulin-Like Growth Factor-Binding Protein 3 Levels, Independent of Insulin-Like Growth Factor 1, Associate with Truncal Fat and Systolic Blood Pressure in South Asian and White European Preschool Children

Patel¹,

Whatmore²,

Davies³

et al. 2013

Horm Res Paediatr

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Aims: To study the effect of the insulin-like growth factor (IGF) system on growth, adiposity and systolic blood pressure (SBP) in early life in British-born South Asian (SA) and White European (WE) children. Methods: The effect of IGF-1 and insulin-like growth factor-binding protein 3 (IGFBP-3) over the first 4 years in 204 healthy SA and WE children was investigated by mixed linear regression modelling. This enabled inclusion of all follow-up observations and adjustment for repeated measures. Results: At birth, SA babies were shorter and lighter than WE babies. Over 4 years, SA ethnicity was associated with lower height, weight and body mass index (BMI) standard deviation score (SDS), higher subscapular/triceps skinfold thickness (Ss/Tr SFT) and lower SBP (all p < 0.01). IGF-1 was associated with greater height (p = 0.03), weight (p < 0.001) and BMI SDS (p < 0.001), and IGFBP-3 with greater weight SDS (p < 0.001), BMI SDS (p = 0.001), Ss/Tr SFT (p = 0.003) and SBP (p = 0.023). Conclusions: Over this first 4-year period of life, SA ethnicity was associated with being shorter, lighter, having more superficial truncal adiposity and lower SBP. IGFBP-3 (and not IGF-1) was independently associated with both superficial truncal adiposity and SBP, suggesting that IGFBP-3 is a potential metabolic and cardiovascular marker in healthy children in the early years of life.

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“…Taking into account the method of BP measurements, in 8 studies the authors used only casual BP measurements [9–11, 15, 17, 20, 21, 23]. In this group the prevalence of hypertension ranged from 10 to 24%.…”

Section: Hypertension In Ex-preterm Newbornsmentioning

confidence: 99%

Prematurity-Related Hypertension in Children and Adolescents

Popławska

Dudek

Koziarz

et al. 2012

International Journal of Pediatrics

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Due to the functional and structural immaturity of different organ systems, preterms have a higher rate of morbidity and mortality. The prevention and treatment of the complications of prematurity is a major challenge in perinatal health care. Recently, there have been several multicenter research trials analysing the impact of prematurity or low birth weight on the health problems of children and adolescents. Many of these studies deal with the issue of pediatric hypertension. An analysis of 15 studies conducted in the years 1998–2011, in which blood pressure values in ex-preterm children were measured, was performed. Comparison was based on several issues: measurement method, cohorts age, size, and birthweight. It has been proven that hypertension occurs more often in former preterm infants; however the etiologic pathways that cause this condition still remain unclear. Moreover, pediatric hypertension is a significant problem, because of its transformation into adult hypertension and increased cardiovascular risk later in life. Therefore it is crucial to introduce wide-spread screening and detection of elevated blood pressure, especially among prematurely born children.

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Fetal Origin of Childhood Disease

Abstract: In term infants, IUGR is linked to risk of hypertension in early childhood, which may be a marker for adult cardiovascular disease.

Cited by 67 publications

References 33 publications

Aorta Structural Alterations in Term Neonates: The Role of Birth and Maternal Characteristics

Aorta Structural Alterations in Term Neonates: The Role of Birth and Maternal Characteristics

Circulating Insulin-Like Growth Factor-Binding Protein 3 Levels, Independent of Insulin-Like Growth Factor 1, Associate with Truncal Fat and Systolic Blood Pressure in South Asian and White European Preschool Children

Prematurity-Related Hypertension in Children and Adolescents

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