Fetal ovarian cysts: an early manifestation of McCune–Albright syndrome?

Abstract

We demonstrate for the first time that voluminous fetal unilateral ovarian cysts may be suggestive of MAS. Systematic search for the Gsα mutation should be performed in all newborns with voluminous fetal unilateral ovarian cysts requiring percutaneous cyst aspiration, because early diagnosis of MAS prevents unnecessary oophorectomy to eliminate questions of malignancy and imposes long-term clinical, biological, and imaging follow-up to detect other early manifestations of MAS.

Outcome of fetal ovarian cysts diagnosed on prenatal ultrasound examination: systematic review and meta‐analysis

“…A total of 1483 articles were identified, of which 52 were assessed for eligibility for study inclusion (Table S2). Thirty‐four studies including a total of 954 fetuses with a prenatal diagnosis of ovarian cysts were included in the systematic review (Table and Figure ).…”

“…The corresponding values in fetuses with simple and complex ovarian cysts were 24.6% (95% CI, 14.2-36.9%) and 64.8% (95% CI, 52.2-76.3%), respectively (Table S6). 15 Thakkar (2015) 16 Nakamura (2015) 17 Marchitelli (2015) 18 Açıkgöz (2015) 19 Jwa (2015) 20 Papic (2014) 21 Karakuş (2014) 22 Turgal (2013) 23 Amari (2013) 24 Dimitraki (2012) 25 Gaspari (2012) 26 Lecarpentier (2012) 27 Nemec (2012) 28 Noia (2012) 29 Aqrabawi (2011) 30 Akin (2010) 31 Eleftheriades (2010) 32 Ben-Ami (2010) 33 Zampieri (2008) 34 Godinho (2008) 35 Shimada (2008) 36 Monnery-Noché (2008) 37 Galinier (2008) 38 Kwak (2006) 39 Foley (2005) 40 Enríquez (2005) 41 Comparetto (2005) 42 Quarello (2003) 43 Mittermayer (2003) 44 Heling (2002) 45 Bagolan (2002) 46 Perrotin (2000) 47 Luzzatto (2000) 48 Only first author of each study is given. A study can be awarded a maximum of one star for each numbered item within Selection and Outcome categories and a maximum of two stars for Comparability.…”

Diagnosis, Management, and Therapy of Fetal Ovarian Cysts Detected by Prenatal Ultrasonography: A Report of 36 Cases and Literature Review

“…Additionally, there have been very few reports of malformations associated with fetal ovarian cysts, and the risk of chromosomal and non-chromosomal syndromes is very low [ 19 ]. However, Gaspari et al reported that McCune-Albright syndrome (MAS) may be associated with fetal ovarian cysts [ 20 ]. Magnetic resonance imaging (MRI) is potentially useful in cases where ultrasonography is non-diagnostic, such as maternal obesity, fetal malposition, and oligohydramnios [ 4 ].…”

Treatment of Antenatally Diagnosed Fetal Ovarian Cysts: A Case Report

“…Prenatal tanılı FOK'de malignite görülmesi çok enderdir. FOK'lerinin kaynağı genelde foliküler epitelyum olabileceği gibi, teka lütein veya corpus luteum kistleri olarak da ortaya çıkabilir (5) . FOK'leri küçük boyutta (<5 cm) ve yaşamın ilk birkaç ayında görülür.…”