Fetal Pancreatic Hamartoma Associated with Hepatoblastoma—An Unusual Tumor Association

Varlas, Valentin Nicolae; Neagu, Oana; Moga, Andreea Alecsandra; Bălănescu, R; Bohiltea, R.E.; Vlădăreanu, Emilia Maria; Bălănescu, Laura

doi:10.3390/diagnostics12030758

Cited by 6 publications

(4 citation statements)

References 31 publications

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“…Different studies showed illiteracy, poverty, and mother occupation as the risk factors significantly associated with VLBW in 2016 highlighting hypocalcemia and hypoglycemia as the risk factors of VLBW [26]. Hypoglycemia problem arises due to the decreased storage of glycogen and fat.…”

Section: Resultsmentioning

confidence: 99%

Risk Factors Associated with Very Low Birth Weight: A Systematic Review and Meta-Analysis

Hussain

Adil

2022

IJIST

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Background: Very Low Birth Weight (VLBW) is due to multiple gestations and reproductive-assisted techniques. Neonatal complications mainly arise in infants with VLBW and Extremely Low Birth Weight (ELBW). The main objective was to study the risk factors associated with VLBW and to conduct a meta-analysis. Methods: A meta-analysis was done to present the most recent risk variables for VLBW. Electronic databases were searched for information on the suggested topic. Using STATA version 14, the relevant data was extracted, and statistical analysis was conducted. Results: A total number of 112 studies have been conducted on the topic of VLBW worldwide from 2000 to 2020. Information from many parts of the world was evaluated in which GDP or per capita income, age, and education were followed in prominent regions of the world. As GDP and education level improved, the nutritional status also improved. Fifteen studies have been identified, with five meeting the inclusion criteria for the metanalysis of VLBW <1500g in developing countries. Illiteracy, poverty, mother occupation, hypocalcemia, and hypoglycemia were the common risk factors of VLBW (<0.05). Conclusion: It was identified that per-capita GDP is inversely proportional to VLBW throughout the world. VLBW in America was found to be significant when compared with central Europe (<0.005), similarly with Southern Europe (<0.03), Northern Europe (<0.00001), Asia (<0.0001), and Africa (<0.0001). Unlike per capita GDP, VLBW was insignificantly related to maternal age in all regions except Africa, where VLBW was significantly associated with maternal age (p<0.0001). In developing countries, illiteracy, poverty, mother occupation, hypocalcemia, and hypoglycemia are the common risk factors for VLBW (<0.05) as the complications related to VLBW are at a high-risk rate, so it is recommended that VLBW babies require special care at the time of birth, especially in poor economic countries.

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Section: Resultsmentioning

confidence: 99%

Risk Factors Associated with Very Low Birth Weight: A Systematic Review and Meta-Analysis

Hussain

Adil

2022

IJIST

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“…Our case shows that pancreatic hamartoma can be preoperatively diagnosed using EUS–FNAB. Pancreatic hamartoma is a very rare, non‐neoplastic, mass‐forming pancreatic lesion, 1 with only 64 cases reported in the English literature and 7 in the Japanese literature, without abstract only (based on literature searches using the PubMed and Japanese Ichushi databases) 1–51 . As pancreatic hamartoma is typically asymptomatic, in more than half the abovementioned reports, the cases has been incidentally discovered 1–51 .…”

Section: Discussionmentioning

confidence: 99%

“…Pancreatic hamartoma is a very rare, non‐neoplastic, mass‐forming pancreatic lesion, 1 with only 64 cases reported in the English literature and 7 in the Japanese literature, without abstract only (based on literature searches using the PubMed and Japanese Ichushi databases) 1–51 . As pancreatic hamartoma is typically asymptomatic, in more than half the abovementioned reports, the cases has been incidentally discovered 1–51 . Furthermore, preoperative diagnosis using various techniques, such as CT, MRI, or US, is extremely difficult because various neoplasms, such as NET, solid pseudopapillary neoplasm, and adenocarcinoma, are included in the differential diagnosis, as described in the case report and literature review by Noguchi et al 1 In our case, the imaging findings suggested NET, although some features were atypical.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic hamartoma: Possibility of a preoperative diagnosis via endoscopic ultrasound–guided fine‐needle aspiration biopsy

Shintaku

Gokita

Oshima

et al. 2023

Diagnostic Cytopathology

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Endoscopic ultrasound-guided fine-needle aspiration biopsy (EUS-FNAB) is useful for preoperatively diagnosing various pancreatic tumors. Although there is a risk of complications, such as pancreatitis, this procedure achieves the crucial need of reducing unnecessary invasive surgery for benign lesions. Herein, we reported a surgically resected case of pancreatic hamartoma in the pancreatic head whose retrospective analysis revealed that the specimens obtained via EUS-FNAB contained hamartoma fragments. Pancreatic hamartoma is an extremely rare benign disease that is exceptionally difficult to diagnose before surgical resection owing to its rarity and lack of established imaging findings. To the best of our knowledge, the preoperative diagnosis of pancreatic hamartoma via EUS-FNAB specimens has not been reported to date. Herein, postoperative EUS-FNAB evaluation revealed a collection of pancreatic hamartoma lesions, although the initial diagnosis was pancreatic tissue with focal atrophy and fibrosis. Diagnosis using EUS-FNAB can be challenging owing to the very small sample size. If mature acini and ducts with fibrous stroma without islets are observed in the EUS-FNAB specimen, pancreatic hamartoma should be considered as a differential diagnosis. Thus, careful follow-up or reexamination of EUS-FNAB should be considered instead of surgery if a benign lesion is suspected preoperatively.

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“…Prognostic factors for hepatoblastoma include the tumor's PRETEXT stage, Evans stage, AFP level at diagnosis, and pathological classification. They are also associated with early detection and timely chemotherapy and surgical treatment before distant metastasis, occurrence of respiratory and heart failure and tumor rupture due to compression effects (14)(15)(16). To improve the prognosis of infants with hepatoblastoma, the importance of early treatment should be emphasized.…”

Section: -Weeks' Gestationmentioning

confidence: 99%

Case Report of Congenital Hepatoblastoma With the Onset at 30-Weeks' Gestation

Yan

Bai

et al. 2022

Front. Pediatr.

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This study reports a case of hepatoblastoma with onset at 30-weeks' gestation and rapid growth rate. The postnatal enhanced CT confirmed an intrahepatic mass with a size of 8.5 cm × 6.6 cm and a clear boundary accompanied by uneven enhancement, displacement, and narrow lumen of the hepatic vein due to compression. The alpha-fetoprotein (AFP) at birth was 1,002,632 ng/ml (normal level 48,406 [±34,718] ng/ml). A diagnosis of congenital hepatoblastoma was established based on the imaging and laboratory outcomes. The infant received chemotherapy of Cisplatin-5 fluorouracil-Vincristine (C5V) on the fourth day after birth. After four courses of C5V, a complete tumor resection was performed, and the postoperative pathology was consistent with mixed epithelial and mesenchymal hepatoblastoma. Four more courses of C5V and one course of C5VD (C5V plus doxorubicin) followed the surgery. Infectious diarrhea and acute kidney injury (stage I) occurred during chemotherapy, which recovered after anti-infection and symptomatic treatment. The patient is currently 2 years old and still in complete remission. In this case, the onset of hepatoblastoma was early, and the tumor grew rapidly, resulting in an obvious compression effect. Chemotherapy was started early after birth, and the curative effect was satisfactory, suggesting that the hepatoblastoma based on clinical diagnosis with rapid tumor progression and severe dysfunction of surrounding organs caused by compression should undergo chemotherapy as soon as possible if a pathological diagnosis cannot be obtained temporarily, which also plays an important role in improving the complete resection rate of intraoperative tumor and reducing the recurrence rate of postoperative tumor.

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Fetal Pancreatic Hamartoma Associated with Hepatoblastoma—An Unusual Tumor Association

Cited by 6 publications

References 31 publications

Risk Factors Associated with Very Low Birth Weight: A Systematic Review and Meta-Analysis

Risk Factors Associated with Very Low Birth Weight: A Systematic Review and Meta-Analysis

Pancreatic hamartoma: Possibility of a preoperative diagnosis via endoscopic ultrasound–guided fine‐needle aspiration biopsy

Case Report of Congenital Hepatoblastoma With the Onset at 30-Weeks' Gestation

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