Fetal profile in fetuses with open spina bifida

Prodan, Natalia; Hoopmann, Markus; Sonek, Jiri; Oettling, Christoph; Abele, Harald; Wagner, Philipp; Kagan, Karl Oliver

doi:10.1007/s00404-020-05503-8

Cited by 5 publications

(3 citation statements)

References 18 publications

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“…MRI is an adjunct to US in diagnosing intracramnial hemorrhages in utero which helps to assess postnatal development [19]. Fetuses with open spina bi da present frequently Dandy-Walker anomaly and descent of the cerebellum in the foramen magnum with a peculiar pro le aspect as described recently [20]. Blake's pouch cysts (Fig.…”

Section: Discussionmentioning

confidence: 94%

Prenatal magnetic resonance imaging of cerebellar dysplasia or malformations and coexistent malformations: A retrospective study in a single institution

Zhou

Huang

et al. 2022

Preprint

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Purpose: To clarify the prenatal magnetic resonance (MR) imaging characteristics of foetal cerebellar dysplasia/hypoplasia and developmental malformations and evaluate their diagnostic value. Methods: We retrospectively reviewed MR images of foetuses with suspected intracranial anomalies on screening ultrasound (US) on picture archiving communication system (PACS) servers within a five-year period in our institution. The main abnormal findings and coexistent anomalies were recorded by two experienced radiologists with census reading. The MRI and US results were paired and compared in each case. Results: We recruited 121 cases (average gestational week, 24.5 ± 4.7 weeks) with prenatal MR imaging, including sixty-two cases with simple cerebellar dysplasia or hypoplasia, thirty-one cases with other anomalies and twenty-eight cases with normal MR imaging findings. Cerebellar anomalies included intracranial haemorrhage, arachnoid cysts, Blake’s pouch cysts, Dandy-Walker malformation, cerebellar tonsil hernia and vermis absence. Coexistent cerebral malformations included hydrocephalus, cerebral haemorrhage, holoprosencephaly, brainstem/gyri malformation, ventriculomegaly and agenesis of the corpus callosum. Other detected systemic malformations included tethered cord syndromes (9 cases), club foot (1 case), cardiac malformation (1 case) and lip-palate cleft (1 case). Among 49 cases with both prenatal MR and US, MR imaging confirmed the diagnosis and/or provided more abnormal findings than US in 12 cases. Two dead babies after birth were recorded in cerebellar malformation group. Conclusion: Prenatal MR imaging could better show cerebellar anomalies and coexistent systemic malformations. As a complementary tool of US, MR imaging could help prenatal counselling and treatment selection at term.

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Section: Discussionmentioning

confidence: 94%

Prenatal magnetic resonance imaging of cerebellar dysplasia or malformations and coexistent malformations: A retrospective study in a single institution

Zhou

Huang

et al. 2022

Preprint

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“…Najčešće se otkriva u drugom trimestu trudnoće, a najzastupljeniji je okultni tip, gde je malformacija prekrivena kožom. Otvorena spina bifida se karakteriše ekspozicijom nervnog tkiva kroz defekt kičmenog stuba i kože (13).…”

Section: Sažetakunclassified

Frequency of skeletal anomalies in fetal and neonatal autopsies

Radojević¹,

Pjevčević²,

Putniković³

et al. 2021

Medicinski podmladak

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Introduction: Skeletal anomalies are a heterogeneous group of disorders including changes in bone shape, size, and density that cause abnormalities of the extremities, trunk, and head. They rank second in Europe in the frequency of all congenital anomalies. The most common skeletal anomalies include head, face and limb anomalies. Aim: The aim of this study was to determine the frequency of skeletal anomalies and their association with anomalies of internal organs, as well as to show the age of the mother and the gestational week of the fetus with established skeletal anomalies. Material and methods: All fetal and neonatal autopsies in the period from January 1, 2018 to December 31, 2020 at the Institute of Pathology "Djordje Joannovic" of the Faculty of Medicine University of Belgrade were analyzed. In the mentioned period, 580 fetal and neonatal autopsies were performed. Clinical data were obtained from the Gynecology and Obstetrics Clinic "Narodni Front" on the basis of completed requests for clinical autopsy. Descriptive statistics methods were used (data are presented as absolute numbers and percentage frequencies). Results: The most common skeletal anomalies are divided into seven groups: spina bifida (20; 33.34%), limb anomalies (16; 26.67%), head and face bone anomalies (15; 25%), joint anomalies (2; 3.33%), achondroplasia (3; 5%), osteogenesis imperfecta (2; 3.33%) and other anomalies (2; 3.33%). The most common associated anomalies were central nervous system (CNS) abnormalities, followed by heart and kidney abnormalities. The youngest mother was 15 years old, and the oldest was 47 years old. The mean age of the mothers was 30 years. Conclusion: In our study, the most common anomaly was spina bifida, while limb anomalies and craniofacial anomalies are next in frequency. Skeletal anomalies were often associated with anomalies of the heart, kidneys, and CNS. They were mostly diagnosed between the 22nd and 27th gestational week. Our results showed that skeletal anomalies are more common in fetuses or neonates of mothers older than 30 years.

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“…e survival rate of fetuses with open spina bifida is extremely low after birth, and even if they can survive, they are often accompanied by lifelong disabilities. erefore, most pregnant women choose to receive diagnosis and treatment as soon as possible, terminate the pregnancy, and abandon the birth of a spina bifida fetus [6,7].…”

Section: Introductionmentioning

confidence: 99%

Neural Network Algorithm-Based Three-Dimensional Ultrasound Evaluation in the Diagnosis of Fetal Spina Bifida

Chen

Tian

Deng

2021

Scientific Programming

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In order to realize the automatic recognition and diagnosis in ultrasound images of fetal spina bifida, the U-Net algorithm was improved in this study to obtain a new convolutional neural network algorithm—Oct-U-Net. 3,300 pregnant women were selected as the research objects, who underwent three-dimensional (3D) ultrasound examinations. Then, Oct-U-Net was applied to evaluate the diagnostic effect of fetal spina bifida by recall rate, precise rate, mean standard error, pixel accuracy (PA), mean intersection over union (MIoU), and running time. Besides, the fully convolutional network (FCN) algorithm and the U-Net algorithm were introduced for comparison. Results showed that recall rate, precise rate, PA, and MioU of Oct-U-Net were 0.93, 0.96, 0.949, and 0.917, respectively, which were markedly higher than those of FCN and U-Net P < 0.05 . The mean standard error of Oct-U-Net was 4.1243, and its average running time was 12.15 seconds. The values of the above two indicators were sharply lower than those of FCN and U-Net P < 0.05 . In conclusion, Oct-U-Net had a better diagnostic effect on 3D ultrasound images of fetal spina bifida, with higher segmentation accuracy and shorter running time, so it was worthy of clinical application.

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Fetal profile in fetuses with open spina bifida

Cited by 5 publications

References 18 publications

Prenatal magnetic resonance imaging of cerebellar dysplasia or malformations and coexistent malformations: A retrospective study in a single institution

Prenatal magnetic resonance imaging of cerebellar dysplasia or malformations and coexistent malformations: A retrospective study in a single institution

Frequency of skeletal anomalies in fetal and neonatal autopsies

Neural Network Algorithm-Based Three-Dimensional Ultrasound Evaluation in the Diagnosis of Fetal Spina Bifida

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