1997
DOI: 10.1523/jneurosci.17-12-04856.1997
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Fetal Transplants Alter the Development of Function after Spinal Cord Transection in Newborn Rats

Abstract: Pieces of fetal spinal tissue were transplanted into the site of complete midthoracic spinal transections in neonatal rat pups (transplant rats). The development of locomotion in these animals was compared with that of unoperated control rats and rats that received spinal transections alone (spinal rats). Reflex, treadmill and overground locomotion, staircase descent, and horizontal ladder crossing for a water reward were tested in control, spinal, and transplant rats from 3 weeks to adulthood. All tests were … Show more

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Cited by 97 publications
(99 citation statements)
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“…Thus, together, of the total 56 NTX rats prepared, we found 13 (23%) were WS and 43 (77%) NWS. These proportions of WS and NWS match many prior published data for such NTX rats from our laboratory and others (Stelzner et al, 1975;Miya et al, 1997;Giszter et al, 2008a). The large sample size and relative stability of proportions between iterations of surgeries give statistical force to the later effects of robot training that we observed.…”
Section: Methodssupporting
confidence: 90%
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“…Thus, together, of the total 56 NTX rats prepared, we found 13 (23%) were WS and 43 (77%) NWS. These proportions of WS and NWS match many prior published data for such NTX rats from our laboratory and others (Stelzner et al, 1975;Miya et al, 1997;Giszter et al, 2008a). The large sample size and relative stability of proportions between iterations of surgeries give statistical force to the later effects of robot training that we observed.…”
Section: Methodssupporting
confidence: 90%
“…With the exception of anesthetic method (we used isoflurane as opposed to hypothermia), spinal transection surgery is largely as described in detail in Miya et al (1997) and Giszter et al (1998Giszter et al ( , 2008a. Neonates were placed under isoflurane anesthesia and maintained on an anesthetic plane (0.75%-2% mixed in oxygen), and sterile procedures were used throughout the surgery.…”
Section: Methodsmentioning
confidence: 99%
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