Fetomaternal Microchimerism and Amniotic Fluid Stem Cells: The Current State of Knowledge

Rosner, Margit; Hengstschläger, Markus

doi:10.1093/clinchem/hvac056

Cited by 2 publications

(2 citation statements)

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“…But on the other hand, these fetal microchimeric cells have also been demonstrated to harbor the potential to play a role in the development of maternal diseases. The molecular processes triggering these different effects can only be elucidated by further research on the cellular origins of fetomaternal microchimerism, including stem cells from the placenta and the amniotic fluid [ 39 , 78 , 120 ]. Next to fetal cell trafficking into the mother´s body, cell-free fetal DNA, which can be found in the plasma of pregnant women, also contributes to the phenomenon known as fetomaternal microchimerism.…”

Section: Multipotent Fetal Stem Cells For Basic Research In Reproduct...mentioning

confidence: 99%

“…Although this non-invasive approach already gained broad clinical acceptance for the detection of common fetal aneuploidies, it has still not reached the diagnostic level so far owing to the occurrence of a significant rate of false results [122,123]. Since the cellular origin of cell-free fetal DNA in the mother is still a matter of debate, it is obvious that further research on potential candidates, such as placenta-and amniotic fluid-derived stem cells, can have important implications for the ongoing expansion of the clinical applications of non-invasive prenatal testing [78,79,[120][121][122].…”

Section: Multipotent Fetal Stem Cells For Basic Research In Reproduct...mentioning

confidence: 99%

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Multipotent fetal stem cells in reproductive biology research

et al. 2023

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Due to the limited accessibility of the in vivo situation, the scarcity of the human tissue, legal constraints, and ethical considerations, the underlying molecular mechanisms of disorders, such as preeclampsia, the pathological consequences of fetomaternal microchimerism, or infertility, are still not fully understood. And although substantial progress has already been made, the therapeutic strategies for reproductive system diseases are still facing limitations. In the recent years, it became more and more evident that stem cells are powerful tools for basic research in human reproduction and stem cell-based approaches moved into the center of endeavors to establish new clinical concepts. Multipotent fetal stem cells derived from the amniotic fluid, amniotic membrane, chorion leave, Wharton´s jelly, or placenta came to the fore because they are easy to acquire, are not associated with ethical concerns or covered by strict legal restrictions, and can be banked for autologous utilization later in life. Compared to adult stem cells, they exhibit a significantly higher differentiation potential and are much easier to propagate in vitro. Compared to pluripotent stem cells, they harbor less mutations, are not tumorigenic, and exhibit low immunogenicity. Studies on multipotent fetal stem cells can be invaluable to gain knowledge on the development of dysfunctional fetal cell types, to characterize the fetal stem cells migrating into the body of a pregnant woman in the context of fetomaternal microchimerism, and to obtain a more comprehensive picture of germ cell development in the course of in vitro differentiation experiments. The in vivo transplantation of fetal stem cells or their paracrine factors can mediate therapeutic effects in preeclampsia and can restore reproductive organ functions. Together with the use of fetal stem cell-derived gametes, such strategies could once help individuals, who do not develop functional gametes, to conceive genetically related children. Although there is still a long way to go, these developments regarding the usage of multipotent fetal stem cells in the clinic should continuously be accompanied by a wide and detailed ethical discussion.

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Section: Multipotent Fetal Stem Cells For Basic Research In Reproduct...mentioning

confidence: 99%

Section: Multipotent Fetal Stem Cells For Basic Research In Reproduct...mentioning

confidence: 99%

Multipotent fetal stem cells in reproductive biology research

et al. 2023

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Spiral Theory of the Human Body: The Positive and Negative Space in Human Embryonic Development

Pirovski,

Ivanova,

Hamza

2022

TJS

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The accumulated amount of information about human morphology is enormous and this leads to a suitable environment for a new qualitative leap in the understanding of the human body. Material and Methods: Scientific publications available online. The methodology is: heuristic formation of the goal, systematic thinking, holistic approach, and comparison between the up-to-date embryology facts with the modern theories in physics and the traditional holistic philosophies of China. Aim: The purpose of this report is to validate STHB from an embryological point of view. Results: The embryonic period provides clear evidence for the spiral theory of the human body, demonstrating the center, its boundary, the equal importance of negative and positive structures, the primordial scale and the transition to different sub-scales, its short duration, and the clear transition to the next period of life. Conclusion: Most axioms of the STHB could be validated by human embryo development. As a disadvantage, one can consider the weak anthropological demonstration of the typical human characteristics that distinguish him from the animal world.

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Fetomaternal Microchimerism and Amniotic Fluid Stem Cells: The Current State of Knowledge

Cited by 2 publications

References 14 publications

Multipotent fetal stem cells in reproductive biology research

Multipotent fetal stem cells in reproductive biology research

Spiral Theory of the Human Body: The Positive and Negative Space in Human Embryonic Development

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