Fetomaternal Outcome of Pregnancy with COVID-19: An Observational Study in Tertiary Care Hospitals of Pakistan

Khan, N.; Wasim, Zahra; Rizwan, Aesha Sadaf; Ahmad, Afshan; Tahir, Muhammad Zahid; Hashmi, Irum Batool

doi:10.53350/pjmhs211561903

Cited by 4 publications

(4 citation statements)

References 15 publications

(18 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Low hemoglobin links to hypoxia, respiratory organ dysfunction, and therefore more adverse outcomes in COVID-19 infection. 16 In consideration of lymphocyte count, it is noteworthy that majority (60.7%) of women, exhibited normal lymphocyte counts, contradictory to finding of a study by Khan et al 7 , which reported a higher percentage (84%) of lymphocytopenia in pregnant women with COVID-19. A higher prevalence of lymphocytopenia was observed in the asymptomatic group compared to the symptomatic group (43.9% vs. 20.4%, with a p-value of 0.000), which is contradictory to the previous study where T lymphocytes and CD4+ T cell count below 200/ml revealed a significant relationship with symptomatology and mortality.…”

Section: Discussionmentioning

confidence: 89%

“…In the present study majority of the pregnant women were found to be asymptomatic similar to other national and international studies where majority of the COVID-19 patients, pregnant and general population, were asymptomatic or presented with mild respiratory symptoms. [5][6][7] Fever, cough, and body ache were most common symptoms, 69.2%, 35.5%, and 34.6%, respectively. Similar to our results, local studies 8,9 and a study by Chen et al also identified fever and cough as its predominant clinical manifestations, 10 whereas sore throat, chest pain, loss of taste and smell, diarrhea and difficulty in breathing were few other symptoms reported in these study.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The clinical manifestations and pregnancy outcomes of COVID-19 infection at a tertiary care hospital

Wali,

Ali,

Bibi

et al. 2023

Pak J Med Sci

View full text Add to dashboard Cite

Objective: To evaluate clinical presentation and pregnancy outcomes in pregnant women with Covid-19 infection in our local tertiary care from lower middle-income country. Methods: A retrospective study was conducted at Obstetrics & Gynecology department, Sheikh Saeed Memorial Hospital (SSMH) of The Indus Hospital and Health Network (IHHN) from March 2020 to August 2021. Data of 422 admitted pregnant women with COVID-19 infection was retrieved for demographic and clinical information, laboratory tests, pregnancy outcome, and neonatal outcomes on RED-Cap and analyzed on SPSS 26. Univariate and multivariable logistic regression analyses were performed to estimate odds ratios (OR) for symptomology with categorical variables and feto-maternal outcome. Results: Of the total 422 pregnant women, 24.4% were symptomatic, 74.7% exhibiting mild symptoms. Largely reported symptoms were fever (71.8%), cough (36.9%) and body ache (35.0%); while odds of symptomatic COVID-19 infection was less in educated pregnant women (OR 0.3; 95% CI 0.1-0.9) compared to uneducated. Amongst maternal comorbidities, odds of having symptomatic COVID-19 infection were 3.8 times (95% CI 1.1-13.0) in women with chronic hypertension and 5.5 times (95% CI 2.9-10.4) in women with diabetes. Symptomatic women had significantly greater incidence of miscarriages (p= 0.009), PPROM (p= 0.001), preterm birth (p= 0.000), preeclampsia (p= 0.000), placental abruption (p= 0.006) and maternal ICU admission (p= 0.000) than asymptomatic patients. Still birth was higher (6.4% vs 1.3%, p-value= 0.013) in symptomatic group. The odds of having severe maternal outcome were higher (OR=3.5; 95% CI 1.9-6.0) in symptomatic pregnant women. Conclusion: Majority of pregnant women were asymptomatic. Symptomatic women with COVID-19 infection had an increased risk of adverse feto-maternal outcome. doi: https://doi.org/10.12669/pjms.40.2(ICON).8949 How to cite this: Wali AS, Ali MM, Bibi R, Rahim A. The clinical manifestations and pregnancy outcomes of COVID-19 infection at a tertiary care hospital. Pak J Med Sci. 2024;40(2):S15-S20. doi: https://doi.org/10.12669/pjms.40.2(ICON).8949 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

show abstract

Section: Discussionmentioning

confidence: 89%

Section: Discussionmentioning

confidence: 99%

The clinical manifestations and pregnancy outcomes of COVID-19 infection at a tertiary care hospital

Wali,

Ali,

Bibi

et al. 2023

Pak J Med Sci

View full text Add to dashboard Cite

show abstract

“…Although others were seen to have developed slight complications, as COVID-19 during pregnancy was associated with adverse fetal and maternal outcomes. 24,25…”

Section: Resultsmentioning

confidence: 99%

Frequency of Covid-19 in Pregnant Women and its Effects on Fetal and Maternal Outcome

Rana¹,

Abbas²,

Parveen³

et al. 2022

PJMHS

View full text Add to dashboard Cite

Objective: To determine the frequency of COVID-19 in pregnant women and its effects on feto-maternal outcomes at a tertiary care hospital. Methods: Present cross-sectional study was conducted at the department of gynae and OBS, at Ziauddin University and Hospital Karachi, from April, 2020 to August 2020. All the pregnant women at term who were admitted for delivery in maternity unit, aged more than 18 years old, and of either parity, were included. After taking written and verbal informed consent women were offered to be tested for SARS-COV2 via Nasopharyngeal PCR swab test. Those women who tested positive for the COVID-19 test were treated according to the severity of the symptoms, and asymptomatic and clinically sound patients were shifted to isolation rooms. Women who presented in spontaneous labour were treated as SARS COV2 positive for safety purposes. SPSS version 22 was used to perform the analysis, all of the data. Results: A total of 454 pregnant females were tested for SARS-CoV2 via a nasopharyngeal PCR swab test, and 12 (3%) women tested positive. Out of the 12 women testing positive, 4 were preterm births, and no significant association was found between COVID PCR being positive (p=0.00) and preterm birth (p=0.112). Five out of 12 women testing positive had an episode(s) of leaking. There was a strong association between COVID PCR being positive and episodes of leaking (p=0.001). Three out of 12 women testing positive had fetal distress, while 19 out of 454 women testing negative had fetal distress (p=0.004). There were no cases of APH or PPH reported in women testing positive; however, out of 442 women testing negative, 1 APH and 3 PPH were reported. There was no mortality in either of the patients, mother or neonate. Conclusion: As per the study conclusion, the frequency of COVID-19 among women during pregnancy was observed to be only 3%, which was significantly linked to the pneumonia, leaking, and fetal distress. Keywords: Covid-19, pregnancy, complications, mortality

show abstract

“…Through inhalation through the mouth or the nose, these aerosols might reach the lungs. The early phases of the COVID-19 epidemic are depicted in Table 1 (7).…”

Section: Outbreak Of Covid-19 Pandemic In Chinamentioning

confidence: 99%

An Observational Study on the Early Stages of the Covid-19 Pandemic in Pakistan

Nasir¹,

Mehdi²,

Qureshi³

et al. 2023

PJMHS

View full text Add to dashboard Cite

Bachground: The coronavirus disease 2019 (COVID-19) pandemic, which started on February 26, 2020 in city of karachi, spread quickly throughout Pakistan. Material and Method: The design of this study was a observational study design and this study was conducted at king Edward medical University Lahore. More than 6,200 persons were afflicted by the illness in the first seven weeks, and there were more than 111 documented fatalities. Many problems arise if we contrast the COVID-19 tragedies in Pakistan with those in nations like China, Iran, and the European Union. The geography of the nation, poverty, poor literacy rates, environmental circumstances, sanitary conditions, and dietary habits are only a few of the difficulties we face in containing this epidemic. Although there are terrible circumstances in each of these areas, Pakistan's COVID-19 epidemic was slower than that of other developing nations. Results: The impact of COVID-19 appears to be lessened by Pakistan's humid hot temperature, early reaction to COVID-19, population immune system, BCG vaccination, and the proportion of young individuals. In this essay, we explore the COVID-19 pandemic outbreak in China, Iran, and Pakistan and present its day-to-day changes. We outline the COVID-19 structure and how it compares to SARS-COV and SARS-COV2. The use of Remdesivir (an adenosine analogue used against RNA viruses), Chloroquine (a widely used anti-malarial drug), convalescent plasma, neutralising antibodies targeting the ACE-2 receptor, and an ACE-2-like molecule that might bind to the S protein of the coronavirus are also covered in terms of treatment options and their drawbacks. Also covered are the effects of COVID-19 on Pakistan's economy and government relief measures. Conclusion: In conclusion, it may be said that the support systems in place may not be sufficient to stop the spread of the virus. Even with the meagre assistance offered, it is weaker for rural places where the virus's effects may be severe than in the nation's cities. Further research is required as the epidemic develops to better understand governmental efforts to contain the virus and its effects across the nation. Keywords: Coronavirus COVID-19 Pakistan Pandemic Outbreak

show abstract

Fetomaternal Outcome of Pregnancy with COVID-19: An Observational Study in Tertiary Care Hospitals of Pakistan

Cited by 4 publications

References 15 publications

The clinical manifestations and pregnancy outcomes of COVID-19 infection at a tertiary care hospital

The clinical manifestations and pregnancy outcomes of COVID-19 infection at a tertiary care hospital

Frequency of Covid-19 in Pregnant Women and its Effects on Fetal and Maternal Outcome

An Observational Study on the Early Stages of the Covid-19 Pandemic in Pakistan

Contact Info

Product

Resources

About