Fetoprotein and albumin levels in the blood serum of developing neonatal pigs

Karlsson, Börje W.

doi:10.1016/0010-406x(70)90281-1

Cited by 26 publications

(15 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This increase in AFP content can either be explained by a synthesis of AFP, or by a release of AFP synthesized by liver cells before birth. As colostrum does not contain AFP (Karlsson, 1970), any contribution via ab sorption from the gut can be excluded.…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown in the pig that marked changes occur in the concentration of AFP, albumin and total serum proteins during the neonatal period (Karlsson, 1968(Karlsson, , 1970. In most animal species the concentration of AFP decreases successively after birth (Ruoslahti and Seppald, 1972;Sell et al, 1974;Gitlin, 1975), whereas the pig shows increased levels of AFP (Karlsson, 1970).…”

mentioning

confidence: 99%

“…In most animal species the concentration of AFP decreases successively after birth (Ruoslahti and Seppald, 1972;Sell et al, 1974;Gitlin, 1975), whereas the pig shows increased levels of AFP (Karlsson, 1970).…”

mentioning

confidence: 99%

“…Furthermore we wanted to describe the changes in the concentrations of these proteins during fetal and neonatal development using isolated, pure AFP and albumin as standards ( 'Carlsson et al, 1976'Carlsson et al, , 1977. This was carried out in order to supplement and adjust earlier values presented by this laboratory (Karlsson, 1970(Karlsson, , 1972. The results will be used in further studies concerning the function of AFP and the regulation of its synthesis.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Synthesis of α-Fetoprotein, Albumin and Total Serum Protein in Neonatal Pigs

Ingvarsson¹,

Carlsson²,

Karlsson³

1978

Neonatology

View full text Add to dashboard Cite

Studies on the incorporation of ³H-leucine established that synthesis of α-fetoprotein (AFP) does occur in the neonatal pig. This synthesis probably accounts for the increase in AFP concentration from 0.46 mg/ml on the day after birth to the maximum value of 1.02 mg/ml found 5 days after birth. After the 5th day, the concentration decreases successively and AFP cannot be detected by electroimmunoassay in the sera of 8-week-old pigs. During the first 3 weeks of extrauterine life, the albumin concentration in serum increases from 3 mg/ml to approximately 30 mg/ml due mainly to increased synthesis of albumin. The concentration of AFP in the fetal pig serum decreases from 3 mg/ml at 6.5 cm crown-to-rump (CR) length to 0.8 mg/ml at 28 cm CR length, whereas the albumin concentration increases from 0.2 mg/ml at 6.5 cm CR length to 1.0 mg/ml at 28 cm CR length. The total serum protein content in the fetus is approximately 20 mg/ml irrespective of gestational age. During the first day after birth there is a marked increase in both the synthesis and the concentration of total serum proteins. The concentration rises to 70 mg/ml during the first day and then slowly declines to 65 mg/ml during the 3 weeks following birth.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

Synthesis of α-Fetoprotein, Albumin and Total Serum Protein in Neonatal Pigs

Ingvarsson¹,

Carlsson²,

Karlsson³

1978

Neonatology

View full text Add to dashboard Cite

show abstract

“…In most mammals the serum level of AFP decreases successively during the neonatal period (Karlsson et al, 1972;Sell et al, 1974). In the pig, however, there is an increase in the concentration of serum AFP after birth with a maximum around the fifth day of extrauterine life (Karlsson, 1970).…”

mentioning

confidence: 99%