Fever, Hypotension, and a Worsening Necrotic Wound

Peterson, Danielle; Damsky, William; Vesely, Matthew D.

doi:10.1001/jama.2022.2806

Cited by 3 publications

(2 citation statements)

References 11 publications

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“…Chronic hard-to-heal wounds are considered as those that fail to heal by 40 to 50% after over 4 weeks of standard management, including diabetic ulcers, pressure sores, etc. Treatment of a chronic hard-to-heal wound and its therapeutic impediments have always attracted great concern in health care and medical fields, bringing about substantial economically challenging burdens worldwide (1)(2)(3)(4)(5). Hypoxia and infection are two non-negligible issues during the occurrence, development, and prognosis of chronic wound healing (6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Living microecological hydrogels for wound healing

et al. 2023

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Chronic hard-to-heal wounds draw great attention worldwide, as their treatments are limited by infections and hypoxia. Inspired by the natural oxygen production capacity of algae and the competitive advantage of beneficial bacteria over other microbes, we presented a living microecological hydrogel (LMH) with functionalized Chlorella and Bacillus subtilis encapsulation to realize continuous oxygen delivery and anti-infections for promoting chronic wound healing. As the hydrogel consisted of thermosensitive Pluronic F-127 and wet-adhesive polydopamine, the LMH could keep liquid at a low temperature while quickly solidifying and tightly adhering to the wound bed. It was demonstrated that by optimizing the proportion of the encapsulated microorganism, the Chlorella could continuously produce oxygen to relieve hypoxia and support the proliferation of B. subtilis , while B. subtilis could eliminate the colonized pathogenic bacteria. Thus, the LMH substantially promoted the healing of infected diabetic wounds. These features make the LMH valuable for practical clinical applications.

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Section: Introductionmentioning

confidence: 99%

Living microecological hydrogels for wound healing

et al. 2023

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“…Clinical manifestations and positive blood culture results can help distinguish between these 2 entities ( 6 ). Although painful ulcers can also present in pyoderma gangrenosum (PG) and peripheral artery disease (PAD), PG cases are usually associated with systemic diseases, such as inflammatory bowel diseases and rheumatoid arthritis ( 7 ). Furthermore, pedal pulses are difficult to palpate in patients with PAD ( 8 ).…”

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confidence: 99%