Fevers in Adult Lupus Patients

Timlin, Homa; Syed, Abrahim; Haque, Uzma; Adler, Brittany; Law, Genevieve; Machireddy, Kirthi; Manno, Rebecca L.

doi:10.7759/cureus.2098

Cited by 10 publications

(12 citation statements)

References 41 publications

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“…Fever is commonly present in SLE, and occurs in 36% to 86% of patients [28]. According to Canadian anuthors, confirmed by our observation, cases of increased body temperature are usually noted at early stage of disease [29].…”

Section: Discussionsupporting

confidence: 78%

“…According to Canadian anuthors, confirmed by our observation, cases of increased body temperature are usually noted at early stage of disease [29]. Fever is considered a symptom of SLE after exclusion of its other possible causes [28]. For that reason, the parameter -although commonis not included in classification criteria as not specific enough.…”

Section: Discussionmentioning

confidence: 77%

“…Gorączka jest częstym objawem występującym w SLE i dotyczy 36-86% pacjentów [28]. Według na-Dermatology Review/Przegląd Dermatologiczny 2019/3 patients, renal symptoms develop within first 3 years of the diagnosis.…”

Section: Discussionunclassified

“…In that situation, szych obserwacji, a także na podstawie pracy autorów z Kanady przypadki podwyższonej ciepłoty ciała stwierdza się zazwyczaj we wczesnym stadium choroby [29]. Obecność podwyższonej ciepłoty ciała uznaje się za objaw SLE po wykluczeniu innych przyczyn [28]. Dlatego parametr ten -częsty, ale mało swoistynie znalazł się w kryteriach klasyfikacyjnych.…”

Section: Discussionunclassified

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Rapid onset of systemic lupus erythematosus with rarely observed cutaneous lesions

Skręta-Śliwińska¹,

Woźniacka²,

Kurnatowska³

et al. 2019

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Introduction. Systemic lupus erythematosus is a multi-organ connective tissue disease of heterogeneous clinical presentation. Objective. This article presents a case of a fulminant disease in a woman in which acute cutaneous lesions preceded multi-organ dysfunction, including acute kidney injury. Case report. Papular eruptions demonstrating a tendency to exudate and formation of erosions appeared on the patient's facial skin. Erosions were present on oral mucosa, and maculopapular lesions developed on thighs. Lesions were accompanied by high fever, general malaise and pain of muscles and joints. Haematological and immunological abnormalities as well as a decrease in kidney function were observed. A rapid development of systemic lupus erythematosus was diagnosed an the treatment with glucocorticosteroids, cyclophosphamide, plasmapheresis and haemodialysis was introduced, resulting in remission. Conclusions. Acute onset of systemic lupus erythematosus often imitates an infectious disease. Presence of cutaneous lesions typical for systemic lupus erythematosus allows early diagnosis and introduction of appropriate treatment. streszczenie Wprowadzenie. Toczeń rumieniowaty układowy jest wielonarządową chorobą tkanki łącznej o heterogennym obrazie klinicznym. Cel pracy. Przedstawienie przypadku choroby o piorunującym przebiegu u kobiety, u której zmiany skórne o charakterze ostrym poprzedziły dysfunkcję wielonarządową, w tym ostre uszkodzenie nerek. Opis przypadku. U pacjentki na skórze twarzy pojawiły się obrzękowe wykwity grudkowe z tendencją do wysięku i tworzenia nadżerek. Na błonie śluzowej jamy ustnej obecne były nadżerki, a na udach zmiany o charakterze plamisto-grudkowym. Zmianom towarzyszyła wysoka Case report/opis przypadku rapid onset of systemic lupus erythematosus with rarely observed cutaneous lesions Gwałtowny początek tocznia rumieniowatego układowego z rzadko obserwowanymi zmianami skórnymi

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Section: Discussionsupporting

confidence: 78%

Section: Discussionmentioning

confidence: 77%

Section: Discussionunclassified

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Rapid onset of systemic lupus erythematosus with rarely observed cutaneous lesions

Skręta-Śliwińska¹,

Woźniacka²,

Kurnatowska³

et al. 2019

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“…Systemic lupus erythematosus (SLE) is a multisystem disease with a variety of different clinical symptoms. Fever is a common manifestation in SLE, seen in 36% to 86% of patients [1-2]. Lupus-associated fevers may be related to disease activity, but should be closely evaluated for infection, drug reaction, thromboembolism, malignancy, or other etiology.…”

Section: Introductionmentioning

confidence: 99%

Anakinra for Recurrent Fevers in Systemic Lupus Erythematosus

Dein¹,

Ingolia²,

Connolly³

et al. 2018

Cureus

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Fever is a common manifestation in systemic lupus erythematosus (SLE) and may be associated with disease activity, but should be closely evaluated for infection, drug reaction, thromboembolism, malignancy, or other etiology. We present the case of a 44-year-old Peruvian female with SLE with periodic high fevers and elevated high-sensitivity C-reactive protein (hs-CRP) levels, treated with anakinra, an interleukin-1 (IL-1) inhibitor. Following the birth of her first child, she developed frequent episodic fevers followed by multiple hospitalizations, approximately two to three times per year. She was started on anakinra in September 2016 and had improvement of fevers and joint symptoms. On 26-month follow-up, she had one episode of fever with bandemia requiring hospitalization but otherwise remained afebrile with a significant drop in CRP. Anakinra is well-tolerable and safe due to a short half-life. We report that the inhibition of IL-1 may be a safe and effective treatment for recurrent fevers in SLE.

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