Few associations between high‐sensitivity C‐reactive protein and environmental factors in 4.5‐year‐old children

Mustonen, Kirsi; Keski‐Nisula, Leea; Vaarala, Outi; Pfefferle, Petra Ina; Renz, Harald; Riedler, Josef; Dalphin, Jean‐Charles; Buechele, Gisela; Lauener, Roger; Braun‐Fahrländer, Charlotte; Mutius, Erika von; Pekkanen, Juha

doi:10.1111/j.1399-3038.2012.01306.x

Cited by 13 publications

(11 citation statements)

References 20 publications

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“…The six food allergens were hen's egg, cow's milk, peanut, hazelnut, carrot, and wheat. Any allergic sensitization was defined as a positive result [sIgE concentration of 0.35 kU/l or greater at the age of 1 yr and 0.70 kU/l or greater at the age of 4.5 yr ] to any of the tested allergens. Inhalation or food atopy was defined as a positive result to any of the 13 inhalation or six food allergens tested, respectively.…”

Section: Methodsmentioning

confidence: 99%

Inflammatory response and IgE sensitization at early age

Mustonen

Orivuori

Keski‐Nisula

et al. 2013

Pediatric Allergy Immunology

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Section: Methodsmentioning

confidence: 99%

Inflammatory response and IgE sensitization at early age

Mustonen

Orivuori

Keski‐Nisula

et al. 2013

Pediatric Allergy Immunology

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“…In an analysis of 277 Danish children, higher hs-CRP levels at 7 years was associated with an elevated risk of concurrent allergic rhinitis, asthma, and sensitization to aeroallergens, food allergens, or any allergen; yet, no associations were observed between CRP levels at 6 months with later development of allergic outcomes until 7 years [6]. However, in 2 analyses by Mustonen et al [4, 5], children with elevated hs-CRP levels were at a decreased risk of allergic sensitization, though not with atopic dermatitis and asthma. In addition, a study of 4,111 US children and adolescents (2–19 years) reported that increased hs-CRP levels were significantly associated with an elevated risk of atopy and food allergy [7].…”

Section: Discussionmentioning

confidence: 99%

“…material, see www.karger.com/doi/10.1159/000497320) [3-7]. Most of these studies adopted a cross-sectional design [3, 4, 7] and had a small sample size [3-6]. Therefore, we sought to re-examine the interrelation between hs-CRP levels and allergic outcomes using a larger population size and a longitudinal study design.…”

Section: Introductionmentioning

confidence: 99%

High-Sensitivity C-Reactive Protein and Allergic Endpoints in German Adolescents

Yang¹,

Markevych

Harris

et al. 2019

Int Arch Allergy Immunol

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Background: Assessing high-sensitivity C-reactive protein (hs-CRP) in relation to allergic endpoints can shed light on both the mechanisms of allergic disease development and early non-communicable disease prevention. However, only a few epidemiological studies so far have investigated the relationship in children and adolescents, and the results were mixed. Objectives: We sought to examine the interrelation between hs-CRP levels and allergic outcomes using a larger population size and a longitudinal study design. Methods: Complete data were available on 1,955 participants from the 15-years follow-up of the 2 large population-based German birth cohorts – GINIplus and LISA. Serum hs-CRP concentrations were measured using the immunoturbidimetric high-sensitive assay. Six allergic endpoints were used – doctor-diagnosed asthma, doctor-diagnosed eczema, doctor-diagnosed allergic rhinitis, food sensitization, aeroallergen sensitization, and any sensitization. We used generalized estimation equation models to assess the associations between hs-CRP levels and allergic endpoints. Results: Our longitudinal analyses did not detect any significant association between hs-CRP levels and any of the studied allergic outcomes (e.g., asthma, eczema, allergic rhinitis, food sensitization, aeroallergen sensitization, and any sensitization). The results were consistent in a series of sensitivity analyses. Conclusions: Our study suggests that there is no association between hs-CRP levels and any of the allergic endpoints in German adolescents. However, whether allergic diseases are inflammatory conditions and which markers might be most sensitive, remain to be confirmed in future studies.

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“…The food allergens were cow's milk, hen's egg, hazelnut, peanut, wheat, and carrot. Any allergic sensitization was defined as a positive result, i.e., sIgE concentration of 0.35 kU/l or greater at the age of 1 yr and 0.70 kU/l or greater at the age of 6 yr , to any of the tested allergens. Inhalation or food atopy was defined as a positive result to any of the inhalation or food allergens, respectively.…”

Section: Methodsmentioning

confidence: 99%