Fexofenadine HCl Immediate Release Tablets: In vitro Characterization and Evaluation of Excipients

Ahmed, Shahriar; Nazmi, Mehrina; Hasan, Ikramul; Sultana, Sabiha; Haldar, Shimul

doi:10.3329/bpj.v16i1.14483

Cited by 4 publications

(4 citation statements)

References 5 publications

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“…A droplet of liquid was deposited on double-sided carbon tape and dried at room temperature for the evaporation of water and then coated with gold. The morphological evaluation was performed by transmission electron microscopy (TEM, EM-1200EX, Japan) 13 .…”

Section: Transmission Electron Microscopy (Tem)mentioning

confidence: 99%

Untitled

2019

IJPSR

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Clopidogrel bisulphate (CB) is the rate of dissolution often controls a sparingly soluble orally administered drug and the rate of absorption. Reports suggest that the drug has poor water solubility which may be challenging for developing liquid dosage forms of Clopidogrel bisulphate. Hence in the present study, we sought to develop orodispersible nanoparticles to enhance the solubility by an anti-solvent evaporation technique using stabilizers as PVPK-30, Poloxamer-188, PVA, L-arginine and tween-80. We found that the particle size was ranging between 154.7 nm to 844.2 nm and % Drug entrapment efficiency was 42.4% to 97.1% respectively. Among all the formulations, F3 stabilized with L-arginine and PVA has been found to show 92.62 ± 0.81% drug release at the end of 10 min in both 0.1N HCl and phosphate buffer (pH6.8).Through SEM studies we found that the particles were small with no aggregation. Further, the particles (F3) were compressed into tablets F3(c) through direct compression method and characterized based on some selected parameters in comparison with the marketed tablet. We have also observed a satisfactory clopidogrel excipient compatibility through FT-IR investigation. DSC and XRD results have illustrated that the crystallinity of drug was lost in lyophilized powder and tablet converted to an amorphous form. Hence, we concluded that the optimized formulation of Clopidogrel bisulphate could improve the rate of absorption controlled by the rate of dissolution. QUICK RESPONSE CODE

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Section: Transmission Electron Microscopy (Tem)mentioning

confidence: 99%

Untitled

2019

IJPSR

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“…All these samples were grounded and mixed thoroughly with potassium bromide, at 1:5 (sample : potassium bromide) weight ratio. The spectrum obtained was in between the wave number of 4000-400 cm -1 (15,16) .…”

Section: Fourier Transform Infrared Spectroscopy (Ft-ir)mentioning

confidence: 99%

Preparation and Evaluation of Cefixime Nanocrystals

Hussein¹,

Mahmood²

2017

IJPS

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Drug nanocrystals are nanoscopic crystals of the parent compound with dimensions less than 1 Âµm. A decrease in particle size will lead to an increase in effective surface area in the diffusion layer, which, in turn, increases the drug dissolution rate. Drug nanocrystals are one of the most important strategies to enhance the oral bioavailability of hydrophobic drugs. Cefixime is the first member of what is generally termed the third generation orally active cephalosporins. These third generation cephalosporins are distinct from the older Î²-lactam antibiotics in their intensive antibacterial activity against a wide range of gram-negative bacteria. The aim of this study is to prepare nanocrystals of cefixime as a capsules dosage form in order to increase its oral dissolution rate and bioavailability. The cefixime nanocrystals were prepared by solvent/antisolvent precipitation method. Certain amount of drug was dissolved in water miscible solvent (methanol used in this study), then this solution was injected (at certain speed) into water containing stabilizer. Upon injection, precipitation of cefixime nanocrystal will occur immediately; this precipitate is sonicated at 37 ËšC for 30 min. then lyophilized. Powder of nanocrystal was obtained and filled into capsules. The physicochemical interaction between drug and addatives was studied using FTIR, DSC, Results show that the best formula of cefixime nanocrystals prepared by dissolving 20mg/ml of cefixime in methanol, then 5ml was injected at 60ml/hr rate to a 50ml PVP solution as stabilizer in concentration 0.05%, then lyophilized to obtain the cefixime nanocrystal powder. The resulted mean particle size was 9-11 nm and the dissolution rate was significantly higher than that of the raw cefixime powder (p>0.05). Keywords: Cefixime trihydrate, Nanocrystals, Anti-solvent precipitation, PVP, HPMC, Poloxamer 188.

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“…The disintegrants are added to a tablet or capsule formulation to help in the breakup of the tablet when it is in contact with a liquid. They are employed in immediate release solid dosage forms such as tablets or capsules to increase dissolution and hence bioavailability of any drug [7][8][9][10].…”

Section: Introductionmentioning

confidence: 99%