2020
DOI: 10.1016/j.yexcr.2020.112108
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FGF21 mitigates atherosclerosis via inhibition of NLRP3 inflammasome-mediated vascular endothelial cells pyroptosis

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Cited by 69 publications
(55 citation statements)
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“…Additionally, an FGF21 analog reduces expression of pro-inflammatory and increases expression of anti-inflammatory genes in non-human primate adipose tissue (183). Finally, FGF21 reduces expression and activation of the NLRP3 inflammasome in vascular endothelial cells in diabetic mice (184), which both protects the cells themselves and reduces further inflammatory damage by suppressing pyroptosis and immune cell recruitment (185).…”
Section: Fibroblast Growth Factor-21 Exerts Direct Anti-inflammatory mentioning
confidence: 99%
“…Additionally, an FGF21 analog reduces expression of pro-inflammatory and increases expression of anti-inflammatory genes in non-human primate adipose tissue (183). Finally, FGF21 reduces expression and activation of the NLRP3 inflammasome in vascular endothelial cells in diabetic mice (184), which both protects the cells themselves and reduces further inflammatory damage by suppressing pyroptosis and immune cell recruitment (185).…”
Section: Fibroblast Growth Factor-21 Exerts Direct Anti-inflammatory mentioning
confidence: 99%
“…Several studies have shown a protective role of FGF-21 against atherosclerosis via the regulation of different signalling pathways involved in inflammation, oxidative stress, cholesterol synthesis, and cell viability. In ApoE −/− mice, FGF-21 treatment was described to mitigate atherosclerosis through the inhibition of NLRP3, the inhibition of factor-associated suicide (FAS) signalling, the reduction of cholesterol accumulation through the promotion of autophagy and by suppressing hepatic cholesterol synthesis, increasing adiponectin production by adipocytes, and attenuating endoplasmic-reticulum-stress-induced apoptosis [ 329 , 330 , 331 , 332 , 333 ]. In rats with atherosclerosis, FGF-21 decreases inflammation by increasing the signalling of nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response elements (ARE) and by reducing the expression of NF-κB [ 334 , 335 ].…”
Section: Role Of Some Adipokines In Inflammatory Processes Associamentioning
confidence: 99%
“…Administration of FGF21 has been reported to improve atherosclerosis risk factors, including blood glucose concentrations, blood lipids, and weight in animal models using rodents and primates [ 8 , 9 ]. Several studies have been conducted to investigate the role of FGF21 in atherosclerosis [ 6 , 7 , 10 , 11 , 12 ]. A study using ApoE −/− mice reported that the administration of FGF21 alleviated atherosclerosis by ameliorating Fas-mediated apoptosis [ 12 ].…”
Section: Discussionmentioning
confidence: 99%
“…Another study demonstrated the protective effect of FGF21 on the proliferation and migration of vascular smooth muscle cells via inhibition of the nucleotide-binding domain leucine-rich repeat and pyrin domain containing receptor 3 (NLRP3) inflammasome [ 11 ]. A recent study also found that FGF21 treatment reduced the aortic sinus plaque area and ameliorated dyslipidemia in ApoE −/− mice [ 10 ]. Several mechanisms have been suggested for this effect such as improvements in mitochondrial function, decreased oxidative stress, and a reduction in NLRP3-related pyroptosis [ 13 ].…”
Section: Discussionmentioning
confidence: 99%