FGF21 promotes wound healing of rat brain microvascular endothelial cells through facilitating TNF-α-mediated VEGFA and ERK1/2 signaling pathway

Chen, Weiting; Shen, Zhongen; Cai, Shuiqi; Chen, Long; Wang, Da-Bin

doi:10.17219/acem/133494

Cited by 4 publications

(3 citation statements)

References 38 publications

(41 reference statements)

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“…Males in the HCD strains showed downregulated of Vegfa , a member of both the platelet-derived and vascular endothelial growth factor families that has been shown to suppress apoptosis [ 109 ]. This ethanol-induced downregulation is consistent with previous FASD literature that also show decreases in Vegfa expression after exposure to ethanol during development [ 110 , 111 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Genetics and Sex on Acute Gene Expression Changes in the Hippocampus Following Neonatal Ethanol Exposure in BXD Recombinant Inbred Mouse Strains

et al. 2022

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Fetal alcohol spectrum disorders (FASD) are prevalent neurodevelopmental disorders. Genetics have been shown to have a role in the severity of alcohol’s teratogenic effects on the developing brain. We previously identified recombinant inbred BXD mouse strains that show high (HCD) or low cell death (LCD) in the hippocampus following ethanol exposure. The present study aimed to identify gene networks that influence this susceptibility. On postnatal day 7 (3rd-trimester-equivalent), male and female neonates were treated with ethanol (5.0 g/kg) or saline, and hippocampi were collected 7hrs later. Using the Affymetrix microarray platform, ethanol-induced gene expression changes were identified in all strains with divergent expression sets found between sexes. Genes, such as Bcl2l11, Jun, and Tgfb3, showed significant strain-by-treatment interactions and were involved in many apoptosis pathways. Comparison of HCD versus LCD showed twice as many ethanol-induced genes changes in the HCD. Interestingly, these changes were regulated in the same direction suggesting (1) more perturbed effects in HCD compared to LCD and (2) limited gene expression changes that confer resistance to ethanol-induced cell death in LCD. These results demonstrate that genetic background and sex are important factors that affect differential cell death pathways after alcohol exposure during development that could have long-term consequences.

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Section: Discussionmentioning

confidence: 99%

Effects of Genetics and Sex on Acute Gene Expression Changes in the Hippocampus Following Neonatal Ethanol Exposure in BXD Recombinant Inbred Mouse Strains

et al. 2022

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“…Further investigation was undertaken to gain a deeper understanding of the downstream pathways affected by VEGFA. It has been demonstrated that VEGFA binding to its receptor can activate some downstream signaling pathways, including the AKT/mTOR pathway [ 29 ], the SRC pathway [ 35 ], the ERK/MAPK pathway [ 36 ], and others. Prior research has suggested that the AKT/mTOR signaling pathway is crucial in fundamental biological mechanisms implicated in the growth and progression of tumors, including cell proliferation [ 37 ], programmed cell death [ 38 ], and angiogenesis [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

The In Vitro Promoting Angiogenesis Roles of Exosomes Derived from the Protoscoleces of Echinococcus multilocularis

Zhou,

Li,

Yang

et al. 2024

J. Microbiol. Biotechnol.

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Alveolar echinococcosis (AE) is a persistent parasite condition that causes the formation of tumor-like growths. It is a challenge to treat the disease. These growths need neovascularization to get their oxygen and nutrients, and the disease is prolonged and severe. Considerable research has been conducted on exosomes and their interactions with Echinococcus multilocularis in the context of immunological evasion by the host. However, the extent of their involvement in angiogenesis needs to be conducted. The primary objective of this investigation was to preliminarily explore the effect of exosomes produced from E. multilocularis protoscoleces (PSC-exo) on angiogenesis, to elucidate the mechanism of their roles in the regulation of the downstream pathway of VEGFA activation, and to provide ideas for the development of novel treatments for AE. The study evaluated the impact of PSC-exo increases proliferation, migration, invasion, and tube formation of HUVECs at concentrations of up to 50 μg/ml. In addition, the study sought to validate the findings in vivo. This effect involved increased VEGFA expression at gene and protein levels and AKT/mTOR pathway activation. PSC-exo are crucial in promoting angiogenesis through VEGFA upregulation and AKT/mTOR signaling. This research contributes to our knowledge of neovascularization in AE.

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“…For example, TNF-ɑ, by mediating VEGFA and ERK1/2 signaling pathways, upregulated the activity of brain microvascular endothelial cells and promoted wound healing. 29 The IL-17 signaling pathway regulates skin repair by safeguarding the metabolic adaptation of wound epithelial cells. 30 The GO and KEGG enrichment analysis on the 1st, 3rd, 5th, and 7th days shown that the enrichment scores of many functional items and signaling pathways on the 7th day were higher than those on the 1st day, suggesting that these subsequently upregulated functions and pathways might be involved in long-term skin repair and reconstruction.…”

Section: Discussionmentioning

confidence: 99%

Dynamic panoramic presentation of skin function after fractional CO2 laser treatment

Guo¹,

Zhang²,

Li³

et al. 2023

iScience

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FGF21 promotes wound healing of rat brain microvascular endothelial cells through facilitating TNF-α-mediated VEGFA and ERK1/2 signaling pathway

Abstract: promotes wound healing of rat brain microvascular endothelial cells through facilitating TNF-α-mediated VEGFA and ERK1/2 signaling pathway.

Cited by 4 publications

References 38 publications

Effects of Genetics and Sex on Acute Gene Expression Changes in the Hippocampus Following Neonatal Ethanol Exposure in BXD Recombinant Inbred Mouse Strains

Effects of Genetics and Sex on Acute Gene Expression Changes in the Hippocampus Following Neonatal Ethanol Exposure in BXD Recombinant Inbred Mouse Strains

The In Vitro Promoting Angiogenesis Roles of Exosomes Derived from the Protoscoleces of Echinococcus multilocularis

Dynamic panoramic presentation of skin function after fractional CO2 laser treatment

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