FGF7-like gene is associated with pericentric inversion of chromosome 9, and FGF7 is involved in the development of ovarian cancer

Yasuhara, Toru; Okamoto, Aikou; Kitagawa, Takanori; Nikaido, Takashi; Yoshimura, Tomoaki; Yanaihara, Nozomu; Takakura, Satoshi; Tanaka, Tadao; Ochiai, Kazunori; Ohtake, Yasuyuki

doi:10.3892/ijo.26.5.1209

Cited by 12 publications

(11 citation statements)

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“…It is also worth noting that in the ovarian patient (OV) samples our method identified two bands that are found as part of multiple regions (9q13, 4q13), which may suggest complex rearrangements. The 9q13 band is a known fragile site that is commonly involved in pericentric inversions in the germline linked with ovarian cancer ( 42 ), while 4q13 has been found to have a high rate of copy number variation in BRCA1 associated ovarian cancers ( 43 ).…”

Section: Resultsmentioning

confidence: 99%

Identification of large-scale genomic variation in cancer genomes usingin silicoreference models

Killcoyne

Sol

2015

Nucleic Acids Res

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Identifying large-scale structural variation in cancer genomes continues to be a challenge to researchers. Current methods rely on genome alignments based on a reference that can be a poor fit to highly variant and complex tumor genomes. To address this challenge we developed a method that uses available breakpoint information to generate models of structural variations. We use these models as references to align previously unmapped and discordant reads from a genome. By using these models to align unmapped reads, we show that our method can help to identify large-scale variations that have been previously missed.

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Section: Resultsmentioning

confidence: 99%

Identification of large-scale genomic variation in cancer genomes usingin silicoreference models

Killcoyne

Sol

2015

Nucleic Acids Res

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“…A higher prevalence of inv(9) has been reported in couples with habitual abortion and a history of more than two spontaneous first trimester abortions,6 aborted fetuses,6 and among the schizophrenia population 17. Although no specific or common manifestations have been identified in these populations, a few studies have reported that inv(9) is sometimes associated with various clinical phenotypes related to fertilization,18 fetal development,19 morphogenesis,11,12 growth,15 acute leukemia,20 and ovarian cancer 21…”

Section: Discussionmentioning

confidence: 99%

De NovoPericentric Inversion of Chromosome 9 in Congenital Anomaly

Jeong

Kim

2010

Yonsei Med J

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PurposeThe pericentric inversion of chromosome 9 is one of the most common structural balanced chromosomal variations and has been found in both normal populations and patients with various abnormal phenotypes and diseases. The aim of this study was to re-evaluate the clinical impact of inv(9)(p11q13).Materials and MethodsWe studied the karyotypes of 431 neonates with congenital anomalies at the Pediatric Clinic in Ajou University Hospital between 2004 and 2008 and retrospectively reviewed their clinical data.ResultsChromosomal aberrations were detected in 60 patients (13.9%). The most common type of structural abnormality was inv(9)(p11q13), found in eight patients. Clinical investigation revealed that all eight cases with inv(9)(p11q13) had various congenital anomalies including: polydactyly, club foot, microtia, deafness, asymmetric face, giant Meckel's diverticulum, duodenal diaphragm, small bowel malrotation, pulmonary stenosis, cardiomyopathy, arrhythmia, and intrauterine growth restriction. The cytogenetic analysis of parents showed that all of the cases were de novo heterozygous inv(9)(p11q13).ConclusionSince our results indicate that the incidence of inv(9)(p11q13) in patients with congenital anomalies was not significantly different from the normal population, inv(9)(p11q13) does not appear to be pathogenic with regard to the congenital anomalies. Some other, to date unknown, causes of the anomalies remain to be identified.

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“…We also found in Sirt1-Tg mice several downregulated protein kinases with pro-tumorigenic roles: Aurora kinase B (Aurkb); protein kinase C-iota (Prkci), and MAP-kinase activating death domain (Madd) [55][56][57]. Instead, a different group of protumoral genes was reduced in Sirt1-Tg pneumocytes in the pulse + chase experiment, in particular genes related to the extracellular matrix (Mmp2 [64], Lamb1 [65]), or secreted growth factors or their receptors (Fgf7 [66], Fgfr1 [67], Pdgfra [68]). Finally, several activators of apoptosis and inhibitors of proliferation were also overexpressed in Sirt1-Tg pneumocytes, as Timp2, Hoxa5, Fas, P3h3, Cav1, and Cdkn2c [58][59][60][61][62][63].…”

Section: Sirt1-tg Pneumocytes Display An Anti-tumorigenic Profile Durmentioning

confidence: 99%

Sirt1 protects from K‐Ras‐driven lung carcinogenesis

et al. 2018

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The NAD-dependent deacetylase SIRT1 can be oncogenic or tumor suppressive depending on the tissue. Little is known about the role of SIRT1 in non-small cell lung carcinoma (NSCLC), one of the deadliest cancers, that is frequently associated with mutated K-RAS Therefore, we investigated the effect of SIRT1 on K-RAS-driven lung carcinogenesis. We report that SIRT1 protein levels are downregulated by oncogenic K-RAS in a MEK and PI3K-dependent manner in mouse embryo fibroblasts (MEFs), and in human lung adenocarcinoma cell lines. Furthermore, Sirt1 overexpression in mice delays the appearance of K-Ras-driven lung adenocarcinomas, reducing the number and size of carcinomas at the time of death and extending survival. Consistently, lower levels of SIRT1 are associated with worse prognosis in human NSCLCs. Mechanistically, analysis of mouse Sirt1-Tg pneumocytes, isolated shortly after K-Ras activation, reveals that Sirt1 overexpression alters pathways involved in tumor development: proliferation, apoptosis, or extracellular matrix organization. Our work demonstrates a tumor suppressive role of SIRT1 in the development of K-RAS-driven lung adenocarcinomas in mice and humans, suggesting that the SIRT1-K-RAS axis could be a therapeutic target for NSCLCs.

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FGF7-like gene is associated with pericentric inversion of chromosome 9, and FGF7 is involved in the development of ovarian cancer

Cited by 12 publications

References 0 publications

Identification of large-scale genomic variation in cancer genomes usingin silicoreference models

Identification of large-scale genomic variation in cancer genomes usingin silicoreference models

De NovoPericentric Inversion of Chromosome 9 in Congenital Anomaly

Sirt1 protects from K‐Ras‐driven lung carcinogenesis

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