2020
DOI: 10.3390/s20113086
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Fiber Optic Particle Plasmon Resonance-Based Immunoassay Using a Novel Multi-Microchannel Biochip

Abstract: A novel multi-microchannel biochip fiber-optic particle plasmon resonance (FOPPR) sensor system for the simultaneous detection of multiple samples. The system integrates a novel photoelectric system, a lock-in module, and an all-in-one platform incorporating optical design and mechanical design together to improve system stability and the sensitivity of the FOPPR sensor. The multi-microchannel FOPPR biochip has been developed by constructing a multi-microchannel flow-cell composed of plastic material to monito… Show more

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Cited by 9 publications
(7 citation statements)
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References 37 publications
(67 reference statements)
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“…Afterwards, as stated above, the AuNPs were self-assembled on the uncovered part of the optical fiber [ 28 ], an image of the AuNPs on the optical fiber was taken by a field-emission scanning electron microscope and the size distribution of the AuNPs was determined according to the SEM image. The microchannel chip preparation and packaging processes were performed according to prior work [ 29 ]; it was cleaned with deionized (DI) water, dried with nitrogen and stored at room temperature.…”
Section: Methodsmentioning
confidence: 99%
“…Afterwards, as stated above, the AuNPs were self-assembled on the uncovered part of the optical fiber [ 28 ], an image of the AuNPs on the optical fiber was taken by a field-emission scanning electron microscope and the size distribution of the AuNPs was determined according to the SEM image. The microchannel chip preparation and packaging processes were performed according to prior work [ 29 ]; it was cleaned with deionized (DI) water, dried with nitrogen and stored at room temperature.…”
Section: Methodsmentioning
confidence: 99%
“…Afterward, the anti-IgG was incubated on the sensing chip surface, and the unreacted -COO − group was encased and intercepted by diethanolamine. The prior study [19] indicated that nonspecific adsorption could be prevented, and the AuNP-cystamine-GOanti-IgG chip could be completed, as shown in Figure 6. Afterward, the nonspecific adsorption and specificity tests were performed to validate the sensing result.…”
Section: Nonspecific Adsorption and Specificity Testsmentioning
confidence: 95%
“…Finally, the sensor resolutions of the developed sensor and the RI sensor reported in references were analyzed. These included the bifacial grating waveguide coupling biosensor (sensor resolution = 4.09 × 10 −5 RIU) [6], surface plasmon resonance sensor (sensor resolution = 7.8 × 10 −5 RIU) [53], prism coupling multimode planar waveguide sensor (sensor resolution = 3 × 10 −5 RIU) [54], fiber optic particle plasmon resonance sensor (sensor resolution = 6.23 × 10 −6 RIU) [19], and tilted conical fiber sensor (sensor resolution = 8.7 × 10 −6 RIU) [55]. The above references show that the sensor resolution of the developed sensor was the same order of magnitude.…”
Section: Optical Waveguide Localized Surface Plasmon Resonance Ri Sensormentioning
confidence: 99%
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“…According to sensor response data in real time from known concentrations, the streptavidin detection limit is 0.53 ± 0.01 nM, and the anti-DNP antibody detection limit is 0.34 ± 0.002 nM. 66 The adoption of green tactics, such as the use of environmentally friendly nanomaterials (green NMs), can address concerns related to toxicity, biocompatibility, and safety associated with NM-based breath sensors for disease diagnosis. Life cycle assessments (LCAs) play a crucial role in evaluating the environmental impact of NMbased breath sensors at every stage, from extraction to disposal.…”
Section: Exploring the Future Of Optical Biochip Sensors: Challenges ...mentioning
confidence: 99%