Fiber-Optic Sensors for Biomedical Applications

Peterson, John I.; Vurek, Gerald G.

doi:10.1126/science.6422554

Cited by 285 publications

(112 citation statements)

References 27 publications

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“…Similarly, the intensity of the remitted radiation can be influenced in a known manner by the analyte of interest (pO 2 , pCO 2 , pH). For pO 2 measurement, the intensity of the emitted fluorescent light is decreased (quenched) by oxygen [8,16], and the quantitative relationship between the observed fluorescent intensity (I) and pO 2 is described by the Stern-Volmer equation (…”

Section: Discussionmentioning

confidence: 99%

Brain oxygen monitoring: in-vitro accuracy, long-term drift and response-time of Licox- and Neurotrend sensors

Hoelper

Alessandri

Heimann

et al. 2005

Acta Neurochir (Wien)

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SummaryBackground. Oxygen tension sensors have been used to monitor tissue oxygenation in human brain for several years. The working principals of the most frequently used sensors, the Licox (LX) and Neurotrend (NT), are different, and they have never been validated independently for correct measurement in vitro. Therefore, we tried to clarify if the two currently available sensors provide sufficient accuracy and stability.Method. 12 LX oxygen tension sensors and NT sensors were placed into a liquid-filled tonometer chamber. The solution was kept at 37 AE 0.2 C and equilibrated with five calibration gases containing different O 2 -and CO 2 -concentrations. After equilibration, readings were taken for each gas concentration (accuracy test). Afterwards, the sensors were left in 3% O 2 and 9% CO 2 and readings were taken after 24, 48, 72, 96 and 120 hours (drift test). Thereafter, a 90% response time test was performed transferring sensors from 1% to 5% oxygen concentration and back, using pre-equilibrated tonometers.Findings. All Licox oxygen probes [12] were used for this study. Two of 14 Neurotrend sensors did not calibrate, revealing a failure rate of 14% for NT. Oxygen tension during the accuracy test was measured as follows: 1% O 2 (7.1 mmHg): LX 6.5 AE 0.4, NT 5.3 AE 2.3 mmHg, 2% O 2 (14.2 mmHg): LX 12.9 AE 0.6, NT 12.1 AE 2.2 mmHg, 3% O 2 (21.4 mmHg): LX 19.8 AE 0.7, NT 19.4 AE 2.4 mmHg, 5% O 2 (35.8 mmHg): LX 33.4 AE 1.0 mmHg, NT 33.5 AE 2.9 mmHg, 8% O 2 (57.0 mmHg): 53.8 AE 1.5, NT 53.6 AE 3.3 mmHg. After 120 hours in 3% O 2 (21 mmHg), LX measured 19.8 AE 1.9 mmHg, NT 17.9 AE 4.7 mmHg. 90% response time from 1% to 5%=5% to 1% oxygen concentration was 129 AE 27=174 AE 26 sec for LX, 55 AE 19=98 AE 39 sec for NT.Conclusions. Both systems are measuring oxygen tension sufficiently, but more accurately with LX probes. NT sensors read significantly lower pO 2 in 1% O 2 and show an increasing deviation with higher oxygen concentrations which was due to two of twelve probes. A slight drift towards lower oxygen tension readings for both sensors but more pronounced for the NT does not impair long-term use. NT measures pCO 2 and pH very accurately.

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Section: Discussionmentioning

confidence: 99%

Brain oxygen monitoring: in-vitro accuracy, long-term drift and response-time of Licox- and Neurotrend sensors

Hoelper

Alessandri

Heimann

et al. 2005

Acta Neurochir (Wien)

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“…There is a lack of information in this topic of experimental biomechanics which is important to give further ideas on the bone remodeling process around implants, which has been so well studied by other methods. Recently, some review reports appeared in the literature, presenting the application of FOS in biomechanics, in particular dental biomechanics and in biomedical applications [140][141][142][143][144][145][146][147][148], clearly showing the great interest in this type of sensor in research.…”

Section: Other Applicationsmentioning

confidence: 99%

New Trends in Dental Biomechanics with Photonics Technologies

et al. 2015

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“…For example, large-core plastic fibers (> 500 microns) can illuminate sufficient light without significant heat, for applications in car-dash instruments, equipment-inspection light sources, medical instrumentation and image applications [25] with no-electrical requirements. Irrespective of whether FOSs are silicon or plastic based, their applications are in telecommunications, ships, submarines, satellites, office buildings, trains, automobiles, manufacturing plants, scientific labs, trans-oceanic communications links, aerospace, oil and pipeline, civil infrastructures [6,17,26,27], biomedical [28], healthcare systems [1,29] and everywhere communication or data is exchanged [12][See later sections for details].…”

Section: Fabrication and Types Of Optical Fibersmentioning

confidence: 99%

Review on Developments in Fiber Optical Sensors and Applications

Annamdas¹

2012

IJME

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The last couple of decades had witnessed a steep rise in extensive research of optoelectronic and fiber optical communication fields, which resulted in applications focused initially in military, aerospace equipments, and later in health monitoring for medicine, heritage culture and various engineering fields. Health monitoring has attracted the effort of many engineers throughout the world and is fast emerging as a pioneering field. It is helping to improve world economy in two ways; first, directly by providing longevity to all the important structures and secondly, by prevention of untimely failure leading to loss of life and money. This field is very vast, consisting of traditional monitoring methods as well as smart system based methods. The fiber optics belong to finest class of smart materials, there are many types and classifications of fiber optics based on necessity, manufacturer and the end user. This paper, gives a complete over view of fiber sensing systems and their usefulness. In addition, it highlights some of the general fiber optics available in the market with selected examples.

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Fiber-Optic Sensors for Biomedical Applications

Cited by 285 publications

References 27 publications

Brain oxygen monitoring: in-vitro accuracy, long-term drift and response-time of Licox- and Neurotrend sensors

Brain oxygen monitoring: in-vitro accuracy, long-term drift and response-time of Licox- and Neurotrend sensors

New Trends in Dental Biomechanics with Photonics Technologies

Review on Developments in Fiber Optical Sensors and Applications

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