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In this article the development of fiber-optic sensors for biomedical applications is reviewed. Light-carrying fibers are potentially useful in oximetry, dye dilution measurements, laser-Doppler velocimetry, and fluorometry; as physical sensors of temperature, pressure, and radiation; and as chemical sensors of pH, partial pressure of blood gases, and glucose. Emphasis is placed on the principles and ideas used in the various devices rather than on detailed descriptions or critical discussions.

A premature lamb fetus was totally sustained by extracorporeal perfusion with the use of a silicone-membrane blood oxygenator and parenteral nutritional support. The fetus remained in a metabolically stable state lasting several days.

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The fluorescence decay time (tau) was 2 to 5 nanoseconds for proteins and 4 to 5 nanoseconds for flavin, pyridine nucleotide, and vitamin B(6)coenzymes; tau varied widely in 48 compounds measured in water. Altholugh reported values of tau for a few of the soluttions studied were in excellenlt agreement. previously "calculated" lifetimes, in severall instances, are apparently erroneous. Nonexponential decay was detectable with our "nanosecond-flash" apparatus, a modification of the first commercially aavilable unit for determination of tau.