Fiber size spectra and cyclic AMP content of sciatic nerves: Effect of muscle hypoactivity and hyperactivity

Appenzeller, Otto; Ogin, Gary; Palmer, Gene C.

doi:10.1016/0014-4886(76)90029-7

Experimental Neurology

1976

DOI: 10.1016/0014-4886(76)90029-7

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Fiber size spectra and cyclic AMP content of sciatic nerves: Effect of muscle hypoactivity and hyperactivity

Otto Appenzeller

Gary Ogin

Gene C. Palmer

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Cited by 2 publications

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Morphometric analysis of the effects of exenteration and enucleation on the development of third and sixth cranial nerves in the rat

Bronson¹,

Hedley‐Whyte²

1977

J of Comparative Neurology

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The effects on rat cranial nerve growth of removing various amounts of extraocular muscle was studied using morphometric techniques. Growth in the third cranial nerves was found to be severely retarded when most of the muscle tissue was removed. By contrast, removal of the eye alone, leaving extraocular muscles relatively intact, was found to have little or no effect on the subsequent growth of third and sixth cranial nerve fibers and of extraocular muscle fibers. This conclusion could be drawn only through the application of statistical methods which take into account several generally unrecognized facts: frequency distributions of axon circumference and myelin sheath thickness are highly variable from nerve to nerve even in normal rats, which often have more large fibers in left than in right nerves. The bimodal nature of peripheral nerve fiber distributions precludes the use of such parametric tests as the commonly and inappropriately used t-test, but a non-parametric test such as the Kolmogorov-Smirnov test, extensively used in these studies, is inadequate for data comprising several sets of distributions to be compared. The application of the analysis of variance to some of the data and the merits of the procedure are discussed.

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Morphometric analysis of the effects of exenteration and enucleation on the development of third and sixth cranial nerves in the rat

Bronson¹,

Hedley‐Whyte²

1977

J of Comparative Neurology

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show abstract

Structure and Biomechanics of Peripheral Nerves: Nerve Responses to Physical Stresses and Implications for Physical Therapist Practice

2006

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The structural organization of peripheral nerves enables them to function while tolerating and adapting to stresses placed upon them by postures and movements of the trunk, head, and limbs. They are exposed to combinations of tensile, shear, and compressive stresses that result in nerve excursion, strain, and transverse contraction. The purpose of this appraisal is to review the structural and biomechanical modifications seen in peripheral nerves exposed to various levels of physical stress. We have followed the primary tenet of the Physical Stress Theory presented by Mueller and Maluf (2002), specifically, that the level of physical stress placed upon biological tissue determines the adaptive response of the tissue. A thorough understanding of the biomechanical properties of normal and injured nerves and the stresses placed upon them in daily activities will help guide physical therapists in making diagnoses and decisions regarding interventions. [Topp KS, Boyd BS. Structure and biomechanics of peripheral nerves: nerve responses to physical stresses and implications for physical therapist practice.]

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Fiber size spectra and cyclic AMP content of sciatic nerves: Effect of muscle hypoactivity and hyperactivity

Cited by 2 publications

References 11 publications

Morphometric analysis of the effects of exenteration and enucleation on the development of third and sixth cranial nerves in the rat

Morphometric analysis of the effects of exenteration and enucleation on the development of third and sixth cranial nerves in the rat

Structure and Biomechanics of Peripheral Nerves: Nerve Responses to Physical Stresses and Implications for Physical Therapist Practice

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