SUMMARY Myelinated fibres in the human sympathetic paravertebral chain were examined histologically and in single teased fibre preparations in various age groups in subjects dying from disorders not affecting primarily the autonomic nervous system. An increase in fibre density predominantly due to an increase in the number of small fibres was found in older subjects. A correlation between internodal length and fibre diameter was found but the internodes of sympathetic myelinated fibres are shorter for any given diameter than those found on fibres of comparable size in the sural nerve. A reduction in internodal lengths with advancing years was demonstrated. These observations are interpreted to show that Wallerian degeneration and segmental demyelination occur with increasing frequency in old age and that regeneration does not keep pace with successive degenerative events. The deterioration in function of the autonomic nervous system with advancing years may be attributed in part to the changes found in myelinated fibres in the paravertebral sympathetic chain.

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SYNOPSIS White rami communicantes were studied quantitatively in patients with chronic alcoholism or diabetes mellitus. The fascicular area of interganglionic segments of the paravertebral sympathetic chain showed less variation than that previously reported for controls. Fibre densities were higher in the patients than in controls of similar age and the percentage of small fibres in alcoholics and diabetics is larger than in controls. Only 17% of fibres were larger than 5 utm in diameter in the patients, whereas, in controls, 3300 of fibres were larger than 5 ltm in diameter. No correlation between internodal lengths and fibre diameter was found in the patients who showed uniformly short internodes averaging only about haif of internodal distances found in control subjects. The uniformly short internodes are attributed to complete degeneration followed by partial regeneration and are compatible with either Wallerian degeneration or a 'dying back' phenomenon. The short internodal lengths should be reflected in slowed conduction velocities in white rami communicantes and could account for abnormalities in baroreflex activity, sweating, and in visceral dysfunction commonly seen in patients with chronic alcoholism or diabetes.

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