Fiber-tracking does not accurately estimate size of fiber bundle in pathological condition: initial neurosurgical experience using neuronavigation and subcortical white matter stimulation

Kinoshita, Manabu; Yamada, Kazuo; Hashimoto, Naoya; Kato, Aitaro; Izumoto, Shuichi; Baba, Takahito; Maruno, Motohiko; Yoshimine, Toshiki

doi:10.1016/j.neuroimage.2004.07.076

Cited by 254 publications

(166 citation statements)

References 22 publications

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“…The threshold of degrees, whether there is clinical significance or not in tract visualization, remains to be determined. It is reported that intra-operative subcortical neurostimulation may underestimate the fiber tracts (18). However, other authors report the accordance of findings of DTI tractography and subcortical stimulation (4,11).…”

Section: Discussionmentioning

confidence: 92%

Surgical strategy of brain tumors adjacent to the optic radiation using diffusion tensor imaging-based tractography

Tatsuzawa¹,

Owada²,

Sasajima³

et al. 2010

Oncology Letters

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Abstract. The present study evaluated the efficacy of diffusion tensor imaging (DTI)-based tractography in the surgery of brain tumors adjacent to the optic radiation. Of the 14 surgical cases included, 11 had metastatic brain tumors and 3 cerebral gliomas. Additionally, 4 of the 14 patients had pre-operative visual field defects, while the remaining 10 patients experienced no visual impairment. The optic radiations on the lesion side were evident in all 14 patients. On the basis of these tractographic findings, we employed optimal surgical approaches in each patient to avoid injury to the eloquent neural structures, including optic radiation, during surgery. Successful surgical resection was performed in all 14 patients. Of the 14 patients, 2 with visual field defects during the pre-operative period showed improvement in their visual field, and the remaining 12 patients experienced no visual deterioration. DTI-based tractography thus is a feasible modality for the surgical planning of brain lesions adjacent to the optic radiation.

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Section: Discussionmentioning

confidence: 92%

Surgical strategy of brain tumors adjacent to the optic radiation using diffusion tensor imaging-based tractography

Tatsuzawa¹,

Owada²,

Sasajima³

et al. 2010

Oncology Letters

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“…Visualization of the specific white matter pathway does not give accurate information in terms of the size or volume of the fiber bundle, either. 51 Second, fiber tracking based totally on directional consistency computation risks bias in favor of connecting fibers with similar orientations. As mentioned before, highly curved fibers such as the Meyer loop may be easily missed.…”

Section: Limitations Of Diffusion Tractographymentioning

confidence: 99%

Principles and Limitations of Computational Algorithms in Clinical Diffusion Tensor MR Tractography

Chung¹,

Chou²,

Chen³

2010

AJNR Am J Neuroradiol

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SUMMARY:There have been numerous reports documenting the graphic reconstruction of 3D white matter architecture in the human brain by means of diffusion tensor MR tractography. Different from other reviews addressing the physics and clinical applications of DTI, this article reviews the computational principles of tractography algorithms appearing in the literature. The simplest voxel-based method and 2 widely used subvoxel approaches are illustrated first, together with brief notes on parameter selection and the restrictions arising from the distinct attributes of tract estimations. Subsequently, some advanced techniques attempting to offer improvement in various aspects are briefly introduced, including the increasingly popular research tracking tool using HARDI. The article explains the inherent technical limitations in most of the algorithms reported to date and concludes by providing a reference guideline for formulating routine applications of this important tool to clinical neuroradiology in an objective and reproducible manner.ABBREVIATIONS CC ϭ corpus callosum; DTI ϭ diffusion tensor imaging; FA ϭ fractional anisotropy; HARDI ϭ high angular resolution diffusion imaging A t the beginning of the 21st century, the radiologic community witnessed the tremendous technical progress toward noninvasive investigations of the white matter architecture in the central nervous system. Thanks to the advancement of DTI plus the ever-growing computer technology of the socalled tractography methods, a comprehensive visualization of the white matter fiber bundles and their relationships to tumors (Fig 1) can be readily displayed without the need for any surgery.1 Needless to say, the potential implications in presurgical planning are huge, particularly if the related technology can be executed objectively and automatically on a daily basis, with the reliability approaching a level that is highly acceptable in routine practice.This article attempts to provide a pedagogic overview of the aspects of diffusion MR tractography that clinical neuroradiologists may find helpful for routine use. Because an overview of data acquisition via DTI and potential clinical applications has been provided in several review articles, 1-3 only the computational means to perform the tractography will be introduced here. In addition, only selective methods will be mentioned, because detailed comprehensive explanations about the massive amount of newly proposed algorithms are neither necessary nor insightful. At the same time, the ultimate restrictions originating from the computation methods will be addressed. With the basic concepts understood, extensions to more sophisticated algorithms would ideally be easily comprehensible. Finally, we conclude with a suggestive guideline for optimal use of diffusion MR tractography in clinical neuroradiology, emphasizing particularly the preparatory work that ought to be done before routine application. The mathematics in this entire article, though inevitable, will be kept at a minimum to ensure readabili...

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“…DTI-FT is currently intended to virtually reconstruct white matter tracts, but it is not able to investigate the function related to a tract. CSES is the gold standard to map subcortical pathways, and DTI-FT findings can be integrated with intraoperative CSES with or without the implementation of intraoperative navigation devices (Henry et al 2004;Kinoshita et al 2005;Bello et al 2008;Ozawa et al 2009, Leclercq et al 2010Spena et al 2010). The fundamental observation that preoperative DTI-FT cannot itself account for the determination of the presence or absence of functional subcortical tracts in or in the vicinity of the tumor is clearly demonstrated by cases of cystic tumors in which, because of the absence of infiltration and edema, the white matter tract reconstructions are very reliable ( fig.…”

Section: Diffusion Tensor Imaging and Fiber Trackingmentioning

confidence: 99%

Multimodal Approach to the Surgical Removal of Gliomas in Eloquent Brain Regions

Spena¹,

Pepoli²,

Bruno³

et al. 2011

Advances in the Biology, Imaging and Therapies for Glioblastoma

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Fiber-tracking does not accurately estimate size of fiber bundle in pathological condition: initial neurosurgical experience using neuronavigation and subcortical white matter stimulation

Cited by 254 publications

References 22 publications

Surgical strategy of brain tumors adjacent to the optic radiation using diffusion tensor imaging-based tractography

Surgical strategy of brain tumors adjacent to the optic radiation using diffusion tensor imaging-based tractography

Principles and Limitations of Computational Algorithms in Clinical Diffusion Tensor MR Tractography

Multimodal Approach to the Surgical Removal of Gliomas in Eloquent Brain Regions

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