Fiber-type-specific sensitivities and phenotypic adaptations to dietary fat overload differentially impact fast- versus slow-twitch muscle contractile function in C57BL/6J mice

Čiapaitė, Jolita; Berg, S. A. van den; Houten, Sander M.; Nicolay, Klaas; Dijk, Ko Willems van; Jeneson, Jeroen A. L.

doi:10.1016/j.jnutbio.2014.09.014

Cited by 52 publications

(95 citation statements)

References 48 publications

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“…The lack of alteration in twitch or tetanic force among groups from the present study could be due to the limited 3‐month span between baseline (20 weeks of age) and diet interventions (33 weeks of age). As for diet‐induced obesity, 12‐week old male C57BL/6J mice on a 5‐week HFS resulted in no alterations in twitch or tetanic peak force as seen with the present study.…”

Section: Discussionsupporting

confidence: 71%

“…Following in vivo measures, the AGE (TD.94048, Harlan Teklad, Mississauga, ON) and HFS‐AGE (TD.150448, Harlan Teklad, Mississauga, ON) groups were switched to their respective diets (Table ) for the 13‐week diet/aging intervention. The experimental HFS diet was created to be consistent with previous studies examining diet‐induced obesity on either bone or muscle , individually. To account for the higher energy per quantity of HFS diet, protein, and micronutrients were adjusted accordingly, to provide a similar level of these nutrients on the basis of energy .…”

Section: Methodsmentioning

confidence: 99%

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Musculoskeletal structure and function in response to the combined effect of an obesogenic diet and age in male C57BL/6J mice

Bott

Gittings

Fajardo

et al. 2017

Molecular Nutrition Food Res

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Section: Discussionsupporting

confidence: 71%

Section: Methodsmentioning

confidence: 99%

Musculoskeletal structure and function in response to the combined effect of an obesogenic diet and age in male C57BL/6J mice

Bott

Gittings

Fajardo

et al. 2017

Molecular Nutrition Food Res

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“…; Ciapaite et al. ). Thus, in this study, the decrease in fast‐TnT protein levels after a long‐term HFD may partially reflect the fiber type change, and may contribute to impaired muscle contractile force.…”

Section: Discussionmentioning

confidence: 97%

“…Another study also showed that 5 weeks on a HFD reduced tetanic contractile force only in slow‐twitch dominant muscles, but not in fast‐twitch dominant muscles (Ciapaite et al. ). Therefore, being on a HFD for only several weeks do not significantly alter muscle contractile force in fast‐twitch dominant muscles.…”

Section: Introductionmentioning

confidence: 96%

Long-term, but not short-term high-fat diet induces fiber composition changes and impaired contractile force in mouse fast-twitch skeletal muscle

et al. 2017

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In this study, we investigated the effects of a short‐term and long‐term high‐fat diet (HFD) on morphological and functional features of fast‐twitch skeletal muscle. Male C57BL/6J mice were fed a HFD (60% fat) for 4 weeks (4‐week HFD) or 12 weeks (12‐week HFD). Subsequently, the fast‐twitch extensor digitorum longus muscle was isolated, and the composition of muscle fiber type, expression levels of proteins involved in muscle contraction, and force production on electrical stimulation were analyzed. The 12‐week HFD, but not the 4‐week HFD, resulted in a decreased muscle tetanic force on 100 Hz stimulation compared with control (5.1 ± 1.4 N/g in the 12‐week HFD vs. 7.5 ± 1.7 N/g in the control group; P < 0.05), whereas muscle weight and cross‐sectional area were not altered after both HFD protocols. Morphological analysis indicated that the percentage of type IIx myosin heavy chain fibers, mitochondrial oxidative enzyme activity, and intramyocellular lipid levels increased in the 12‐week HFD group, but not in the 4‐week HFD group, compared with controls (P < 0.05). No changes in the expression levels of calcium handling‐related proteins and myofibrillar proteins (myosin heavy chain and actin) were detected in the HFD models, whereas fast‐troponin T‐protein expression was decreased in the 12‐week HFD group, but not in the 4‐week HFD group (P < 0.05). These findings indicate that a long‐term HFD, but not a short‐term HFD, impairs contractile force in fast‐twitch muscle fibers. Given that skeletal muscle strength largely depends on muscle fiber type, the impaired muscle contractile force by a HFD might result from morphological changes of fiber type composition.

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“…In response to short term feeding of rodents with a high fat diet, a number of studies have reported a fast-to-slow fibre type profile shift in skeletal muscle [51–55], associated with a concurrent increase in muscle oxidative capacity [56–58]. In contrast, a single recent study reported slow-to-fast muscle fibre type transformation in response to a more prolonged (1 year) high fat diet in mice [59].…”

Section: Discussionmentioning

confidence: 99%

Dietary supplementation with bovine-derived milk fat globule membrane lipids promotes neuromuscular development in growing rats

et al. 2017

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BackgroundThe milk fat globule membrane (MFGM) is primarily composed of polar phospho- and sphingolipids, which have established biological effects on neuroplasticity. The present study aimed to investigate the effect of dietary MFGM supplementation on the neuromuscular system during post-natal development.MethodsGrowing rats received dietary supplementation with bovine-derived MFGM mixtures consisting of complex milk lipids (CML), beta serum concentrate (BSC) or a complex milk lipid concentrate (CMLc) (which lacks MFGM proteins) from post-natal day 10 to day 70.ResultsSupplementation with MFGM mixtures enriched in polar lipids (BSC and CMLc, but not CML) increased the plasma phosphatidylcholine (PC) concentration, with no effect on plasma phosphatidylinositol (PI), phosphatidylethanolamine (PE), phosphatidylserine (PS) or sphingomyelin (SM). In contrast, muscle PC was reduced in rats receiving supplementation with both BSC and CMLc, whereas muscle PI, PE, PS and SM remained unchanged. Rats receiving BSC and CMLc (but not CML) displayed a slow-to-fast muscle fibre type profile shift (MyHCI → MyHCIIa) that was associated with elevated expression of genes involved in myogenic differentiation (myogenic regulatory factors) and relatively fast fibre type specialisation (Myh2 and Nfatc4). Expression of neuromuscular development genes, including nerve cell markers, components of the synaptogenic agrin–LRP4 pathway and acetylcholine receptor subunits, was also increased in muscle of rats supplemented with BSC and CMLc (but not CML).ConclusionsThese findings demonstrate that dietary supplementation with bovine-derived MFGM mixtures enriched in polar lipids can promote neuromuscular development during post-natal growth in rats, leading to shifts in adult muscle phenotype.Electronic supplementary materialThe online version of this article (doi:10.1186/s12986-017-0161-y) contains supplementary material, which is available to authorized users.

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Fiber-type-specific sensitivities and phenotypic adaptations to dietary fat overload differentially impact fast- versus slow-twitch muscle contractile function in C57BL/6J mice

Cited by 52 publications

References 48 publications

Musculoskeletal structure and function in response to the combined effect of an obesogenic diet and age in male C57BL/6J mice

Musculoskeletal structure and function in response to the combined effect of an obesogenic diet and age in male C57BL/6J mice

Long-term, but not short-term high-fat diet induces fiber composition changes and impaired contractile force in mouse fast-twitch skeletal muscle

Dietary supplementation with bovine-derived milk fat globule membrane lipids promotes neuromuscular development in growing rats

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