Fibrates as therapy for osteoarthritis and rheumatoid arthritis? A systematic review

Eekeren, Inge C. M. van; Clockaerts, S.; Bastiaansen-Jenniskens, Y.M.; Lubberts, E.; Verhaar, Jan A N; Osch, Gerjo J.V.M. van; Bierma-Zeinstra, Sita M A

doi:10.1177/1759720x12468659

Cited by 16 publications

(13 citation statements)

References 55 publications

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“…[25] The macromolecular network forming breaks up at the cartilage surface in OA. [26] Macromolecules of the cartilage extracellular matrix released into synovial fluid, blood, or urine are useful biomarkers that may contribute to the OA pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Women with Osteoarthritis have Elevated Synovial Fluid Levels of Insulin-Like Growth Factor (IGF)-1 and IGF-Binding Protein-3

Hooshmand

Juma

Khalil

et al. 2014

Journal of Immunoassay and Immunochemistry

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The present study explores the possible connection between synovial fluid concentrations of insulin like growth factor (IGF-1), IGF-binding protein (IGFBP-3), leptin, and C-reactive protein (CRP) in osteoarthritis (OA). Synovial fluid specimens were obtained from a total of thirty-four individuals with and without OA. Protein-normalized measurements of IGF-1, IGFBP-3, and leptin concentrations in synovial fluid showed significantly (P < 0.05) elevated levels in women with knee OA but not in men. This study provides initial evidence that protein normalized IGF-1 and IGFBP-3 and leptin levels increase in synovial fluid of women but not in men with OA versus those without OA.

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Section: Discussionmentioning

confidence: 99%

Women with Osteoarthritis have Elevated Synovial Fluid Levels of Insulin-Like Growth Factor (IGF)-1 and IGF-Binding Protein-3

Hooshmand

Juma

Khalil

et al. 2014

Journal of Immunoassay and Immunochemistry

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“…However, subsequent attempts at replicating these early promising results using other fibrates to alleviate muscular pain have not been successful (Biga et al ., ). Nevertheless, these drugs were found to be effective in attenuating pain associated with rheumatoid arthritis and osteoarthritic pain (van Eekeren et al ., ). These findings indicate that synthetic PPARα agonists can have analgesic effects in specific types of pain.…”

Section: Evidence From Clinical Trialsmentioning

confidence: 99%

PPARs and pain

Okine

Gaspar

Finn

2018

British J Pharmacology

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Chronic pain is a common cause of disability worldwide and remains a global health and socio-economic challenge. Current analgesics are either ineffective in a significant proportion of patients with chronic pain or associated with significant adverse side effects. The PPARs, a family of nuclear hormone transcription factors, have emerged as important modulators of pain in preclinical studies and therefore a potential therapeutic target for the treatment of pain. Modulation of nociceptive processing by PPARs is likely to involve both transcription-dependent and transcription-independent mechanisms. This review presents a comprehensive overview of preclinical studies investigating the contribution of PPAR signalling to nociceptive processing in animal models of inflammatory and neuropathic pain. We examine current evidence from anatomical, molecular and pharmacological studies demonstrating a role for PPARs in pain control. We also discuss the limited evidence available from relevant clinical studies and identify areas that warrant further research.

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“…Experimental studies in vivo and in vitro have shown that PPARα agonists inhibit bone resorption and reduce inflammation, the degradation of the synovial fluid, and the destruction of the articular cartilage. Consequently, PPARα ligands reduce pain, diminish joint tumefaction and determine a decrease in inflammatory markers at systemic level [46].…”

Section: The Role Of Pparα Receptors In Rheumatoid Arthritismentioning

confidence: 99%

Peroxisome Proliferator-Activated Receptors - Alpha in Chronic Inflammation - Mini-Review

Popa

Zugun‐Eloae

Zlei

et al. 2019

IJPPE

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The pathogeny of the metabolic syndrome (MetS) is not fully elucidated, but a link between visceral obesity and the increase of the proinflammatory response was proven. Atherosclerosis, perceived as a metabolic complication, draws attention to the peroxisome proliferator-activated receptors-alpha (PPARα). PPARα receptors are transcription factors involved in lipid metabolism, inflammation and atheromatosis. Hence, it interferes in the pathogeny of cardiovascular diseases and other chronic diseases too (neurological, psychical, neoplasical). The study of the expression of PPARα and its modulation on different level may be beneficial in the treatment of metabolic syndrome, intervening in the modulation of another proinflammatory factors. PPAR -Mechanism of ActionThe peroxisome proliferator-activated receptors (PPAR), which comprise three PPAR isoform: PPARα, PPARγ and PPARδ (10), act as transcription factors, belonging to the nuclear receptor superfamily [4-6], The mechanism of action of PPARα (Fig. 1) is similar to that of other nuclear receptors (thyroid or that of vitamin D) [7][8][9]11]. The activation of the PPAR receptor determines a change in the structure of the receptor complex, followed by changes in the expression of coded genes. PPAR acts as a ligand-activated transcription factor [7,12].

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Fibrates as therapy for osteoarthritis and rheumatoid arthritis? A systematic review

Cited by 16 publications

References 55 publications

Women with Osteoarthritis have Elevated Synovial Fluid Levels of Insulin-Like Growth Factor (IGF)-1 and IGF-Binding Protein-3

Women with Osteoarthritis have Elevated Synovial Fluid Levels of Insulin-Like Growth Factor (IGF)-1 and IGF-Binding Protein-3

PPARs and pain

Peroxisome Proliferator-Activated Receptors - Alpha in Chronic Inflammation - Mini-Review

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