Fibrillar Self-Assembly of a Chimeric Elastin-Resilin Inspired Engineered Polypeptide

Bracalello, Angelo; Secchi, Valeria; Mastrantonio, Roberta; Pepe, Antonietta; Persichini, Tiziana; Iucci, Giovanna; Bochicchio, Brigida; Battocchio, Chiara

doi:10.3390/nano9111613

Cited by 8 publications

(8 citation statements)

References 47 publications

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“…In addition, an interesting work was presented by Bracalello et al In particular, they focused on the preparation and structural characterization of nanofibers from a chimer-ic-polypeptide-containing resilin and elastin domain [ 43 ]. The purpose of their research was to enhance its cell-binding ability through introducing a specific fibronectin-derived Arg-Gly-Asp (RGD) sequence.…”

Section: Discussionmentioning

confidence: 99%

Atomic Force Microscopy Imaging of Elastin Nanofibers Self-Assembly

2023

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Elastin is an extracellular matrix protein, providing elasticity to the organs, such as skin, blood vessels, lungs and elastic ligaments, presenting self-assembling ability to form elastic fibers. The elastin protein, as a component of elastin fibers, is one of the major proteins found in connective tissue and is responsible for the elasticity of tissues. It provides resilience to the human body, assembled as a continuous mesh of fibers that require to be deformed repetitively and reversibly. Thus, it is of great importance to investigate the development of the nanostructural surface of elastin-based biomaterials. The purpose of this research was to image the self-assembling process of elastin fiber structure under different experimental parameters such as suspension medium, elastin concentration, temperature of stock suspension and time interval after the preparation of the stock suspension. atomic force microscopy (AFM) was applied in order to investigate how different experimental parameters affected fiber development and morphology. The results demonstrated that through altering a number of experimental parameters, it was possible to affect the self-assembly procedure of elastin fibers from nanofibers and the formation of elastin nanostructured mesh consisting of naturally occurring fibers. Further clarification of the contribution of different parameters on fibril formation will enable the design and control of elastin-based nanobiomaterials with predetermined characteristics.

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Section: Discussionmentioning

confidence: 99%

Atomic Force Microscopy Imaging of Elastin Nanofibers Self-Assembly

2023

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“…Self-assembling polymers have been produced by combining block polypeptides with genes encoding polypeptide sequences. Thanks to their properties, self-assembling polymers are useful in the integration of synthetic devices in the body preventing the invasion of cells [ 48 , 49 ]. Short peptide hydrogels are attractive biomaterials but typically suffer from limited mechanical properties.…”

Section: Polymers Overviewmentioning

confidence: 99%

Biomaterials for Regenerative Medicine in Italy: Brief State of the Art of the Principal Research Centers

Camponogara

Zanotti

Tiengo

et al. 2022

IJMS

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Regenerative medicine is the branch of medicine that effectively uses stem cell therapy and tissue engineering strategies to guide the healing or replacement of damaged tissues or organs. A crucial element is undoubtedly the biomaterial that guides biological events to restore tissue continuity. The polymers, natural or synthetic, find wide application thanks to their great adaptability. In fact, they can be used as principal components, coatings or vehicles to functionalize several biomaterials. There are many leading centers for the research and development of biomaterials in Italy. The aim of this review is to provide an overview of the current state of the art on polymer research for regenerative medicine purposes. The last five years of scientific production of the main Italian research centers has been screened to analyze the current advancement in tissue engineering in order to highlight inputs for the development of novel biomaterials and strategies.

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“…In fact, thanks to the high surface-to-volume ratio, they allow a better interaction with analytes. Furthermore, the possibility of modulating size, shape and functionalization allows their chemical-physical properties to be controlled, such as optical or assembly properties, in order to adapt them to specific needs [ 43 , 44 , 45 , 46 , 47 , 48 ].…”

Section: Agnps Preparation and Use For Water Pollution Monitoring mentioning

confidence: 99%

Silver Nanoparticles for Water Pollution Monitoring and Treatments: Ecosafety Challenge and Cellulose-Based Hybrids Solution

et al. 2020

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Silver nanoparticles (AgNPs) are widely used as engineered nanomaterials (ENMs) in many advanced nanotechnologies, due to their versatile, easy and cheap preparations combined with peculiar chemical-physical properties. Their increased production and integration in environmental applications including water treatment raise concerns for their impact on humans and the environment. An eco-design strategy that makes it possible to combine the best material performances with no risk for the natural ecosystems and living beings has been recently proposed. This review envisages potential hybrid solutions of AgNPs for water pollution monitoring and remediation to satisfy their successful, environmentally safe (ecosafe) application. Being extremely efficient in pollutants sensing and degradation, their ecosafe application can be achieved in combination with polymeric-based materials, especially with cellulose, by following an eco-design approach. In fact, (AgNPs)–cellulose hybrids have the double advantage of being easily produced using recycled material, with low costs and possible reuse, and of being ecosafe, if properly designed. An updated view of the use and prospects of these advanced hybrids AgNP-based materials is provided, which will surely speed their environmental application with consequent significant economic and environmental impact.

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Fibrillar Self-Assembly of a Chimeric Elastin-Resilin Inspired Engineered Polypeptide

Cited by 8 publications

References 47 publications

Atomic Force Microscopy Imaging of Elastin Nanofibers Self-Assembly

Atomic Force Microscopy Imaging of Elastin Nanofibers Self-Assembly

Biomaterials for Regenerative Medicine in Italy: Brief State of the Art of the Principal Research Centers

Silver Nanoparticles for Water Pollution Monitoring and Treatments: Ecosafety Challenge and Cellulose-Based Hybrids Solution

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