Fibrin Adhesives in Surgery of the Renal Parenchyma

Renographic Comparison of Function in Bivalved Kidneys Repaired Using Either a Fibrin Adhesive (Tisseel®) or Conventional Suturing

“…Although renal function was not impaired renographically in healthy baboon kidneys, the histology calls for the discreet use of the fibrin adhesive in dis eased kidneys. The use of the fibrin seal in the manage ment of renal rupture with profuse parenchymal bleed ing seems to be a definite indication [12,14]. However, in this study the fibrin seal did not prove superior to conventional suturing after bivalving the kidney.…”

“…In group A, the fibrin adhesive was prepared and used for induction of haemostasis [14]. Thrombin converts the fibrinogen-cryoprecipitate to an unstable fibrin monomer.…”

Local Hemostasis of Nephrostomy Tract with Fibrin Adhesive Sealing in Percutaneous Nephrolithotomy

“…Fibrin glueing is applied today in many fields of med icine [7,8,15,17], In contrast to the classical tissue glues such as cyanoarylate or the resorcinol-formaldehydegelatine system, a foreign body reaction is not induced. On the contrary, the locally applied clotting factors stim ulate wound healing.…”

“…A nephrostomy catheter is usually in serted postoperatively for a few days in order to attain hemostasis in the parenchymal canal by tamponade. Hemorrhage from the parenchymal vessels is one of the most serious possible complications in percutaneous nephrolithotomy [6,9,13,16,19].Urlesberger et al [17] reported excellent hemostastis with a fibrin glue in renal parenchymal surgery. No post operative complications such as wound infection or kid ney stone formation were observed.…”

Current applications of fibrin sealant in urologic surgery

“…Fibrin sealant has been used since 1979 in open partial nephrectomy (11). The recent advent of minimally invasive techniques for nephron sparing surgery has resulted in widespread fibrin sealant use during laparoscopic partial nephrectomy today (12)(13)(14)(15).…”