Fibrin–Chitosan–Gelatin Composite Film: Preparation and Characterization

Natarajan, N.; Shashirekha, V.; Eusuff, Noorjahan Sheik; Rameshkumar, M.; Rose, C.; Sastry, T. P.

doi:10.1081/ma-200063188

Cited by 33 publications

(30 citation statements)

References 19 publications

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“…The second weight loss (between 249 and 338 • C) of 51.1% is mainly due to the decomposition of protein present in the sheet. This type of protein loss was observed in our earlier studies [12]. The third weight loss of 33.5% between 535 and 635 • C is attributed to the loss of inorganic phase in FCS.…”

Section: Discussionmentioning

confidence: 54%

Preparation and partial characterization of collagen sheet from fish (Lates calcarifer) scales

Sankar

Sekar

Mohan

et al. 2008

International Journal of Biological Macromolecules

100

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Section: Discussionmentioning

confidence: 54%

Preparation and partial characterization of collagen sheet from fish (Lates calcarifer) scales

Sankar

Sekar

Mohan

et al. 2008

International Journal of Biological Macromolecules

100

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“…82 In other studies, a physiologically coated Fbn-chitosan gelatin composite film was shown to provide a fibrous and porous structure with a high water absorption capacity, which could improve the encapsulation efficacy of hydrophilic protein and peptides. 83 Hepatic cell-seeded Fbggelatin matrix stabilized by thrombin exhibited a very high compressive strength. The study also suggested that Fbn could be a favorable biological component for cell assembly/delivery compared with other natural protein-based scaffolds.…”

Section: Fbg and Fbn Tubes As Vascular Graftmentioning

confidence: 99%

Fibrinogen and fibrin based micro and nano scaffolds incorporated with drugs, proteins, cells and genes for therapeutic biomedical applications

Rajangam¹,

An²

2013

IJN

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Over the past two decades, many types of natural and synthetic polymer-based micro-and nanocarriers, with exciting properties and applications, have been developed for application in various types of tissue regeneration, including bone, cartilage, nerve, blood vessels, and skin. The development of suitable polymers scaffold designs to aid the repair of specific cell types have created diverse and important potentials in tissue restoration. Fibrinogen (Fbg)-and fibrin (Fbn)-based micro-and nanostructures can provide suitable natural matrix environments. Since these primary materials are abundantly available in blood as the main coagulation proteins, they can easily interact with damaged tissues and cells through native biochemical interactions. Fbg-and Fbn-based micro and nanostructures can also be consecutively furnished/ or encapsulated and specifically delivered, with multiple growth factors, proteins, and stem cells, in structures designed to aid in specific phases of the tissue regeneration process. The present review has been carried out to demonstrate the progress made with micro and nanoscaffold applications and features a number of applications of Fbg-and Fbn-based carriers in the field of biomaterials, including the delivery of drugs, active biomolecules, cells, and genes, that have been effectively used in tissue engineering and regenerative medicine.

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“…The amount of individual constituents, which gave maximum tensile strength to the FCG composite, was optimized. SEM pictures of the FCG have exhibited the fibrous and porous nature of the composite (Natarajan et al 2005).…”

mentioning

confidence: 99%

Preparation and characterization of fibrin-chitosan composite and its in vivo studies

M¹

2012

iosrphr

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Abstract--Biomaterials are used in regenerative medicine, implantable materials, controlled release carriers or scaffolds for tissue engineering. Biological dressings like fibrin glue, gelatin sheets, chitosan films, collagen is popular for quicker wound healing. These polymers when used in combination such as fibringelatin, fibrin-chitosan has shown better results, than when used alone. Thus, the present research work is concentrated on the preparation and evaluation of composite films made with chitosan-fibrin to ascertain the applicability of the prepared combination for wound management. Temporary biological wound dressings were prepared, in film form, using physiologically clotted fibrin and chitosan (FC) employing PVP as porogen. The films were characterized for their percentage equilibrium water content (% EWC), water vapour transmission rate (WVTR), bacterial penetration, surface morphology and in vivo biodegradation using rats as animal models. The film prepared using fibrin 10ml (40% solids) and chitosan solution 5ml (4% in 0.3N acetic acid) has exhibited better results. The FC films have shown excellent inhibition for bacterial penetration. The micrographs taken for wet membrane have shown swollen strands of fibrin expanding throughout the surface indicating the hydrogel nature of the film. In vivo degradation studies have revealed that the FC is completely biodegradable in 30 days without any adverse foreign body reaction indicating its biocompatibility.Keywords--Chitosan, fibrin, equilibrium water content (% EWC), water vapour transmission rate (WVTR), bacterial penetration, surface morphology, in vivo biodegradation

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Fibrin–Chitosan–Gelatin Composite Film: Preparation and Characterization

Cited by 33 publications

References 19 publications

Preparation and partial characterization of collagen sheet from fish (Lates calcarifer) scales

Preparation and partial characterization of collagen sheet from fish (Lates calcarifer) scales

Fibrinogen and fibrin based micro and nano scaffolds incorporated with drugs, proteins, cells and genes for therapeutic biomedical applications

Preparation and characterization of fibrin-chitosan composite and its in vivo studies

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