Fibrin Degradation Products in Normal and Abnormal Pregnancy and Parturition

Bonnar, J.; Davidson, J. F.; Pidgeon, Christine F.; McNicol, G. P.; Douglas, A. S.

doi:10.1136/bmj.3.5663.137

Cited by 92 publications

(56 citation statements)

References 23 publications

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“…This delayed return to normal fibrinolytic activity after delivery was found in three of the patients with pre-eclampsia. As shown in Fig. 5 the serum fibrin degradation products level was raised before the onset of labour, and in the three days after the eclamptic seizures it greatly increased and far exceeded the levels found in the first week of the normal puerperium (Bonnar et al, 1969a); the platelet count was depressed until after delivery.…”

Section: Resultsmentioning

confidence: 91%

Coagulation and Fibrinolytic Systems in Pre-eclampsia and Eclampsia

Bonnar¹,

McNicol²,

Douglas³

1971

BMJ

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182

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SummaryThe coagulation and fibrinolytic mechanisms were investigated in a group of patients with severe pre-eclampsia and eclampsia and the findings were compared with those of healthy women in late pregnancy. In patients with pre-eclampsia the following significant differences were found: (1) greater depression of plasma fibrinolytic activity (euglobulin lysis time) than in normal pregnancy, (2) a higher level of inhibitor to urokinaseinduced lysis, (3) increased levels of serum fibrin degradation products, and (4) reduced platelet counts.In patients with eclampsia a progressive increase of the level of serum fibrin degradation products was found over the three days following eclamptic seizures. No such increase occurred after grand mal seizures in late pregnancy. The findings in this study support the view that intravascular clotting is taking place in pre-eclampsia and that this disturbance of the balance between coagulation and fibrinolysis may be localized to certain areas of the vascular compartment, particularly the placental and renal circulations. Fibrin deposition in the maternal vessels supplying the placenta would impair the placental blood flow, which may explain the placental insufficiency which occurs in pre-eclampsia. Likewise fibrin deposition in the renal vasculature will result in glomerular damage and proteinuria. Hypertension may be related to the renal

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Section: Resultsmentioning

confidence: 91%

Coagulation and Fibrinolytic Systems in Pre-eclampsia and Eclampsia

Bonnar¹,

McNicol²,

Douglas³

1971

BMJ

Self Cite

182

View full text Add to dashboard Cite

show abstract

“…Plasmaplasminogen Plasma plasminogen was assayed by the caseinolytic method of Remmert and Cohen (1949) as modified by Alkjaersig, Fletcher, and Sherry (1959 Fibrinogen-related antigen Fibrinogen-related antigen (FR-antigen) was assayed by the method of Merskey, Kleiner, and Johnson (1966) using the modifications described by Bonnar, Davidson, Pidgeon, McNicol, and Douglas (1969). The assay was performed on serum stored at -70°C prepared from 5 ml of blood taken into plastic tubes containing 0 1 ml of a 1:20 dilution of Aprotinin, 100000 Kallikrein Inactivator Units per 10 ml (Trasylol, Bayer Pharmaceuticals Ltd, Haywards Heath, UK) and incubated for at least three hours at 37°C in a water bath before the serum was separated.…”

Section: Subjects Studiedmentioning

confidence: 99%

The effect of age on the fibrinolytic enzyme system

Hamilton¹,

Dawson²,

Ogston³

et al. 1974

J Clin Pathol

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“…This syndrome has been associated with many disparate conditions, such as pregnancy toxaemia, septicaemia, amniotic fluid embolism, hypertension, snake bite and shock (e.g., the reviews by Pitney, 1971 and Simpson and Stalker, 1973 Pregnancy is associated with changes in the fibrinogen/plasminogen system, although the details are still subject to dispute probably related to technical differences (Woodfield et al, 1968;Bonnar et al, 1969). A variety of changes in coagulation factors and their inhibitors have been observed in patients receiving oestrogen-progestogen preparations (e.g., Brackman and Astrup, 1964;Ygge et al, 1969;Howie et al, 1970).…”

Section: Discussionmentioning

confidence: 99%

Pancreatitis, multiple infarcts and oral contraception

Foster

Powell

1975

Postgraduate Medical Journal

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Summary The fact that oral contraceptives may predispose to thrombosis is not disputed, although its frequency is still debated. Any reliable assessment of the prevalence of this complication must in the main depend on careful statistical studies of well controlled groups, because the isolated case may well be coincidental when conditions such as coronary thrombosis, cerebral thrombosis, and pulmonary embolism are not extreme rarities in adult women. However, occasionally the clinical and pathological findings are so striking that they afford compelling evidence. The patient to be described presented with clinical features of pancreatitis that did not initially suggest an association with oral contraception. A hitherto undescribed state of multiple infarcts was found at post-mortem. This also illustrates the way in which the official figures for thrombotic complications can be underestimated.

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Fibrin Degradation Products in Normal and Abnormal Pregnancy and Parturition

Cited by 92 publications

References 23 publications

Coagulation and Fibrinolytic Systems in Pre-eclampsia and Eclampsia

Coagulation and Fibrinolytic Systems in Pre-eclampsia and Eclampsia

The effect of age on the fibrinolytic enzyme system

Pancreatitis, multiple infarcts and oral contraception

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