Fibrin-fibrinogen degradation products in cerebrospinal fluid as an indicator of neonatal brain damage

Dalens, B; Bezou, M J; Coulet, M; Raynaud, E. J.

doi:10.1111/j.1600-0404.1981.tb04390.x

Cited by 7 publications

(5 citation statements)

References 5 publications

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“…LEK, β‐EP, and DynoA1‐13 were significantly higher in the severely asphyxiated group than in the moderately asphyxiated group (Cao et al., 1993). FDP was significantly lower in the severely asphyxiated group than in the moderately asphyxiated group (Dalens, Bezou, et al., 1981). ASAT, CK, HBD, and LDH were significantly lower in the severely asphyxiated group than in the moderately asphyxiated group (Dalens, Viallard, et al., 1981).…”

Section: Resultsmentioning

confidence: 99%

“…Neurotransmitters, such as leu‐enkephalin (LEK), β‐endorphin (β‐EP), dynorphin A1‐13 (DynoA1‐13), and 3‐methoxy‐4‐hydroxy‐phenylglycol (MHPAC), were significantly higher in the asphyxiated group (Blennow et al., 1995; Cao et al., 1993). Fibrin–fibrinogen degradation products (FDP), a coagulation marker, were significantly higher in the asphyxiated group (Dalens, Bezou, et al., 1981). In this group, all neurotransmitters tested were considered doubtful for biomarker utility based on our score criteria.…”

Section: Resultsmentioning

confidence: 99%

“…The pattern of CK‐BB fall suggests that the timing of the insult would be a predominant determinant of the level of CK‐BB in the CSF. FDP was highest at P1d, and gradually decreased at 3, 8, and 15d (Dalens, Bezou, et al., 1981).…”

Section: Resultsmentioning

confidence: 99%

“…Thirteen studies (Batra et al, 1998; Blennow et al., 1995; Cao et al., 1993; Dalens, Bezou, et al., 1981; Dalens, Viallard, et al., 1981; Fernandez et al., 1986; Gulcan et al., 2005; Juul et al., 1999; Korhonen et al., 1998; Kumar et al., 2008; Ray et al, 1998; Riikonen et al., 1999; Savman et al., 2013) reported CSF markers in asphyxiated versus non‐asphyxiated cases, including 1,048 test results in the asphyxiated group and 801 test results in the non‐asphyxiated group (Table 1). All of the non‐asphyxiated cases were cases of suspected meningitis or sepsis based on clinical conditions, but were negative for bacterial cultures.…”

Section: Resultsmentioning

confidence: 99%

“…The a priori search strategy produced 390 publications in PubMed and 603 publications in EMBASE. After screening out duplicated studies and unqualified studies, there were 17 studies (Batra et al, 1998; Blennow et al., 1995; Cao et al., 1993; Dalens, Bezou, et al., 1981; Dalens, Viallard, et al., 1981; Fernandez et al., 1986; Gucuyener et al., 1999; Gulcan et al., 2005; Hussein et al., 2010; Juul et al., 1999; Korhonen et al., 1998; Kumar et al., 2008; Ray et al, 1998; Riikonen et al., 1999; Savman et al., 2013; Talvik et al., 1995; Vasiljevic et al., 2011) included in the final quantitative analysis, most of which reported more than one biomarker (Figure 2). All included studies had 7 out of 8 stars according to the Newcastle–Ottawa Quality Assessment Scale (Table S1).…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

A systematic review of noninflammatory cerebrospinal fluid biomarkers for clinical outcome in neonates with perinatal hypoxic brain injury that could be biologically significant

Shi

Luo

Deol

et al. 2021

J of Neuroscience Research

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Neonatal encephalopathy (NE) that purportedly arises from hypoxia-ischemia is labeled hypoxic-ischemic encephalopathy (HIE). Perinatal asphyxia is a clinical syndrome involving acidosis, a low Apgar score and the need for resuscitation in the delivery room; asphyxia alerts one to the possibility of NE. In the present systematic review, we focused on the noninflammatory biomarkers in cerebrospinal fluid (CSF) that are involved in the development of possible brain injury in asphyxia or HIE. A literature search in PubMed and EMBASE for case-control studies was conducted and 17 studies were found suitable by a priori criteria. Statistical analysis used the Mantel-Haenszel model for dichotomous data. The pooled mean difference and 95% confidence intervals (CIs) were determined. We identified the best biomarkers, based on the estimation approach in evaluating the biological significance, out of hundreds in three categories: cell adhesion and proliferation, oxidants and antioxidants, and cell damage. The following subtotal-population comparisons were made: perinatal asphyxia versus no asphyxia, asphyxia with HIE versus asphyxia without HIE, asphyxia with HIE versus no asphyxia, and term versus preterm HIE newborn with asphyxia.Biological significance of the biomarkers was determined by using a modification of the estimation approach, by ranking the biomarkers according to the difference in the bounds of the CIs. The most promising CSF biomarkers for prognostication especially for the severest HIE include creatine kinase, xanthine oxidase, vascular endothelial growth factor, neuron-specific enolase, superoxide dismutase, and malondialdehyde.Future studies are recommended using such a combined test to prognosticate the most severely affected patients.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

A systematic review of noninflammatory cerebrospinal fluid biomarkers for clinical outcome in neonates with perinatal hypoxic brain injury that could be biologically significant

Shi

Luo

Deol

et al. 2021

J of Neuroscience Research

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How Much of Neonatal Encephalopathy Is due to Birth Asphyxia?

Nelson

Leviton²

1991

Arch Pediatr Adolesc Med

144

109

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Colour-coded echographic flow imaging and spectral analysis of cerebrospinal fluid (CSF) in meningitis and hemorrhage

Winkler

1992

Pediatr Radiol

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Using echographic flow imaging (colour Doppler), flow within ventricular CSF-pathways was discovered in an infant with purulent meningitis. 22 mature and 40 premature infants were then investigated for presence of CSF-flow which was detected in a further 5 infants, all premature. Diagnostic criteria for echographic CSF-flow imaging are: 1. flow signals "within" CSF-pathways; 2. to-and-fro movement of CSF (spectral analysis); 3. specific response of CSF-flow to stimuli (respiration, crying, abdominal palpation); 4. dynamic CSF-imaging related to specific anatomical areas of intracranial CSF-pathways. Echographic detection of CSF-flow depends on optimized adjustment of controls, equipment used, meticulous examination technique and awareness of pitfalls on the part of the examiner. A further prerequisite is the presence of scattering particles within CSF, such as red or white blood cells (minimum concentration in the order of one thousand cells/microL) or air. Although echographic CSF-flow imaging is not applicable for excluding the presence of disease, it appears to be a new diagnostic tool with considerable potential allowing selected early and non-invasive diagnosis of CSF-pathology and giving new insights into CSF-hemodynamics.

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Fibrin-fibrinogen degradation products in cerebrospinal fluid as an indicator of neonatal brain damage

Cited by 7 publications

References 5 publications

A systematic review of noninflammatory cerebrospinal fluid biomarkers for clinical outcome in neonates with perinatal hypoxic brain injury that could be biologically significant

A systematic review of noninflammatory cerebrospinal fluid biomarkers for clinical outcome in neonates with perinatal hypoxic brain injury that could be biologically significant

How Much of Neonatal Encephalopathy Is due to Birth Asphyxia?

Colour-coded echographic flow imaging and spectral analysis of cerebrospinal fluid (CSF) in meningitis and hemorrhage

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