Fibrin polymer on the surface of biomaterial implants drives the foreign body reaction

Balabiyev, Arnat; Podolnikova, Nataly P.; Kilbourne, Jacquelyn; Baluch, D. Page; Lowry, David; Zare, Azadeh; Ros, Robert; Flick, Matthew J.; Ugarova, Tatiana P.

doi:10.1016/j.biomaterials.2021.121087

Cited by 48 publications

(44 citation statements)

References 83 publications

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“…It was found that cell adhesion on zwitterion-based hydrogels was obviously Small 2022, 18, 2202596 Moreover, the recognition and activation of immune cells such as macrophages on implanted materials could trigger complex immune responses and promote FBR. [14,27] Thus, we investigated the activation of macrophages on microcapsules with different zwitterion coatings using Raw 264. Raw 264.7 cells were reduced when cultured with zwitterioncoated microcapsules, suggesting that the zwitterionic coatings could effectively inhibit inflammatory activation in vitro.…”

Section: Resultsmentioning

confidence: 99%

“…Moreover, the recognition and activation of immune cells such as macrophages on implanted materials could trigger complex immune responses and promote FBR. [ 14,27 ] Thus, we investigated the activation of macrophages on microcapsules with different zwitterion coatings using Raw 264.7 cells. After induction to the pro‐inflammatory phenotype macrophages by lipopolysaccharide (LPS), Raw 264.7 cells were cultured with different microcapsules, and the concentration of tumor necrosis factor‐α (TNF‐α), a kind of secreted pro‐inflammatory cytokines, was tested.…”

Section: Resultsmentioning

confidence: 99%

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Microfluidic Production of Zwitterion Coating Microcapsules with Low Foreign Body Reactions for Improved Islet Transplantation

Xiao

Wei

et al. 2022

Small

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Microfluidic Production of Zwitterion Coating Microcapsules with Low Foreign Body Reactions for Improved Islet Transplantation

Xiao

Wei

et al. 2022

Small

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“…[81,87,88] In particular, the presence of fibrinogen on the biomaterial surface will control macrophage fusion and the subsequent fibrous capsule formation. [88,89] During the acute inflammatory process that ensues, neutrophils are recruited to the site of implantation. In the case of joint disease, this can be a significant issue, as the tissue would already be primed for a major inflammatory reaction.…”

Section: The Foreign Body Response To Biomaterials Determines Integra...mentioning

confidence: 99%

“…[ 81,87,88 ] In particular, the presence of fibrinogen on the biomaterial surface will control macrophage fusion and the subsequent fibrous capsule formation. [ 88,89 ]…”

Section: Successful Biomaterials Integration Necessitates Balance Of ...mentioning

confidence: 99%

Biomaterial Integration in the Joint: Pathological Considerations, Immunomodulation, and the Extracellular Matrix

Mentzer

Corciulo

Stubelius

2022

Macromolecular Bioscience

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Defects of articular joints are becoming an increasing societal burden due to a persistent increase in obesity and aging. For some patients suffering from cartilage erosion, joint replacement is the final option to regain proper motion and limit pain. Extensive research has been undertaken to identify novel strategies enabling earlier intervention to promote regeneration and cartilage healing. With the introduction of decellularized extracellular matrix (dECM), researchers have tapped into the potential for increased tissue regeneration by designing biomaterials with inherent biochemical and immunomodulatory signals. Compared to conventional and synthetic materials, dECM‐based materials invoke a reduced foreign body response. It is therefore highly beneficial to understand the interplay of how these native tissue‐based materials initiate a favorable remodeling process by the immune system. Yet, such an understanding also demands increasing considerations of the pathological environment and remodeling processes, especially for materials designed for early disease intervention. This knowledge will avoid rejection and help predict complications in conditions with inflammatory components such as arthritides. This review outlines general issues facing biomaterial integration and emphasizes the importance of tissue‐derived macromolecular components in regulating essential homeostatic, immunological, and pathological processes to increase biomaterial integration for patients suffering from joint degenerative diseases.

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“…[ 30 ] Around 7 days after implantation, fibroblasts are recruited to the site and deposit fibrous collagen to encapsulate the implanted biomaterial, which will then adversely affect the compliance of the material and hinder the tissue regeneration process. The formation of FBGCs and fibrotic capsules around a biomaterial implant can be mediated by many factors, including, but not limited to, material morphology, [ 31 ] composition, [ 32 ] and stiffness. [ 33 ]…”

Section: Introductionmentioning

confidence: 99%

Immunomodulation Strategies for the Successful Regeneration of a Tissue‐Engineered Vascular Graft

Zhang

King

2022

Adv Healthcare Materials

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Cardiovascular disease leads to the highest morbidity worldwide. There is an urgent need to solve the lack of a viable arterial graft for patients requiring coronary artery bypass surgery. The current gold standard is to use the patient's own blood vessel, such as a saphenous vein graft. However, some patients do not have appropriate vessels to use because of systemic disease or secondary surgery. On the other hand, there is no commercially available synthetic vascular graft available on the market for small diameter (<6 mm) blood vessels like coronary, carotid, and peripheral popliteal arteries. Tissue-engineered vascular grafts (TEVGs) are studied in recent decades as a promising alternative to synthetic arterial prostheses. Yet only a few studies have proceeded to a clinical trial. Recent studies have uncovered that the host immune response can be directed toward increasing the success of a TEVG by shedding light on ways to modulate the macrophage response and improve the tissue regeneration outcome. In this review, the basic concepts of vascular tissue engineering and immunoengineering are considered. The state-of-art of TEVGs is summarized and the role of macrophages in TEVG regeneration is analyzed. Current immunomodulatory strategies based on biomaterials are also discussed.

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Fibrin polymer on the surface of biomaterial implants drives the foreign body reaction

Cited by 48 publications

References 83 publications

Microfluidic Production of Zwitterion Coating Microcapsules with Low Foreign Body Reactions for Improved Islet Transplantation

Microfluidic Production of Zwitterion Coating Microcapsules with Low Foreign Body Reactions for Improved Islet Transplantation

Biomaterial Integration in the Joint: Pathological Considerations, Immunomodulation, and the Extracellular Matrix

Immunomodulation Strategies for the Successful Regeneration of a Tissue‐Engineered Vascular Graft

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