Fibrin seal adhesive, versus nonabsorable microsuture in peripheral nerve repair

Moy, Owen J.; Peimer, Clayton A.; Koniuch, Mark P.; Howard, Craig; Zielezny, Maria; Katikaneni, P.R.

doi:10.1016/s0363-5023(88)80063-7

Cited by 66 publications

(42 citation statements)

References 9 publications

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“…In a serial electrophysiologic evaluation after section and repair of rabbit sciatic nerve using fibrin glue or suture, Moy et al 4 found that CV re c o ve ry was superior to amplitude re c o v e ry at the same analysed period. In that study, the CV recovery in the animals whose sciatics nerves were submitted to repair with fibrin adhesive was 97 to 98 % of t h e initial CV while the amplitude re c o v e ry was 40 %.…”

Section: Discussionmentioning

confidence: 99%

“…Although direct suturing of the nerve is considered the standard procedure, it can be difficult due to reduced nerve caliber and sometimes can cause inflammatory reaction impairing the axonal re g e n e r a t i o n 1 . The repair with fibrin glue is an alternative to the conventional suture technique, although there is no definitive experimental evaluation of the two techniques [1][2][3][4][5][6][7][8][9][10][11][12][13] . In this study we compared the parameters obtained in the electrophysiologic evaluation in thre e d i ff e rent repairs techniques after the section of the rat sciatic nerve, trying to define which one allows better nerve regeneration.…”

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confidence: 99%

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Electrophysiologic assessment of regeneration in rat sciatic nerve repair using suture, fibrin glue or a combination of both techniques

Martins

Siqueira

Silva

et al. 2005

Arq. Neuro-Psiquiatr.

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-We evaluated the repair of seccioned rat sciatic nerve by the comparison of electro p h y s i o l o gic parameters. The repair was effected with suture (group A), fibrin glue (group B) or a combination of both techniques (group C). The amplitude, latency and conduction velocity of the motor and nerve action potentials were assessed before the nerve section and at reoperation after 24 weeks. There was no diff e rence between the groups when the nerve action potential was evaluated. Rats of group B presented better results than those of group A (p<0.05) when latency and the nerve conduction velocity assessed at the reoperation, and the ratio between the conduction velocity at the reoperation and before the nerve section in the motor action potential evaluation were measured. Animals of group C presented better re s u l t s than those of group A when the ratio between the conduction velocity of motor action potential at the reoperation and before the nerve division was considered (p<0.05). No difference between groups B and C was found. We conclude that repair using fibrin glue presented better results than suture following t r a nsection of sciatic nerve when the motor action potential was evaluated in the rat experimental model. KEY WORDS: fibrin glue, nerve regeneration, suture, sciatic rat nerve.Avaliação eletrofisiológica da eficácia de três tipos de re p a ro após a secção do nervo ciático do rato RESUMO -Foram comparados os parâmetros obtidos na avaliação eletrofisiológica do potencial de ação do nervo e do potencial de ação motor antes e após 24 semanas do re p a ro no nervo ciático do rato pre v i amente seccionado no lado direito com a utilização de sutura (grupo A), adesivo de fibrina (grupo B) ou uma combinação das duas técnicas (grupo C). Não houve diferença entre os grupos na avaliação do potencial de ação do nervo. Quando consideradas a latência e a velocidade de condução mensurados na re o p eração e a razão entre a velocidade de condução medida na reoperação e o mesmo parâmetro antes da secção do nervo, durante a mensuração do potencial de ação motor, os animais do grupo B apre s e n t a r a m melhores resultados em relação aos do grupo A (p<0,05). Os animais do grupo C apresentaram melhores resultados em comparação com os do grupo A quando considerada a razão entre a velocidade de condução medida 24 semanas do re p a ro e antes da secção do nervo durante a avaliação do potencial de ação m o t o r. Conclui-se que os animais em que o re p a ro dos nervos foi realizado com o adesivo de fibrina apresentaram melhores resultados em comparação com a sutura quando considerados os parâmetros obtidos na mensuração do potencial de ação motor. PALAVRAS-CHAVE: adesivo de fibrina, regeneração nervosa, sutura, nervo ciático do rato.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Electrophysiologic assessment of regeneration in rat sciatic nerve repair using suture, fibrin glue or a combination of both techniques

Martins

Siqueira

Silva

et al. 2005

Arq. Neuro-Psiquiatr.

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“…The group with the worst results was the suture alone group (S), especially compared to the MDP-treated group (SFM) at weeks 8 and 12. As some investigators have speculated, neurorrhaphy could hinder nerve regeneration in several ways: by escalating the inflammatory response at the repair point, by causing deviations in the path of those axons otherwise aiming towards the distal segment of the nerve (10), by temporarily reducing blood flow through the microcirculation (11), and via the formation of mechanical obstructions such as scar tissue.…”

Section: Discussionmentioning

confidence: 99%

Effect of neurotrophic factor, MDP, on rats’ nerve regeneration

Fornazari

Rezende

Mattar

et al. 2011

Braz J Med Biol Res

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“…1 Very few attempts have been made to connect torn nerves by microsuture. [2][3][4] Even when such attempts were made, they were rarely successful, because, unlike peripheral nerves, 5 cauda equina nerve roots lacked perineurium to hold the sutured ends securely together. In view of the poor neurological recovery with both of the above-mentioned approaches, particularly in complete injuries, attempt was made by the authors to find a better method of anastomosis to improve outcome.…”

Section: Introductionmentioning

confidence: 99%

The clinical study of repairing cauda equina fibres with fibrin glue after lumbar fracture and dislocation

Sun

Liu

et al. 2010

Spinal Cord

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Study design: A retrospective study. Objectives: To study the outcome of repair of cauda equina fibres with fibrin glue after lumbar fracture and/or dislocation. Methods: Seven acute cases and one chronic case of L2 or L3 fracture and/or dislocation complicated with complete cauda equina injury were selected. Sural nerve or ventral roots of injured cauda equina were chosen to repair the motor cauda equina fibres with fibrin glue after open reduction and internal fixation of the unstable vertebrae. The functional recovery after surgery was observed. Results: Recovery of the strength of thigh muscles (iliopsoas, quadriceps femoris, gluteus maximus, adductors) was observed in all seven acutely injured patients (t ¼ 3.74, Po0.05), but not in the chronic one. Neither recovery of leg muscles nor sensation of the lower extremities was observed in any case. Conclusions: The cauda equina ventral roots injured after lumbar fracture and/or dislocation can be repaired with fibrin glue and motor recovery is expected.

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Fibrin seal adhesive, versus nonabsorable microsuture in peripheral nerve repair

Cited by 66 publications

References 9 publications

Electrophysiologic assessment of regeneration in rat sciatic nerve repair using suture, fibrin glue or a combination of both techniques

Electrophysiologic assessment of regeneration in rat sciatic nerve repair using suture, fibrin glue or a combination of both techniques

Effect of neurotrophic factor, MDP, on rats’ nerve regeneration

The clinical study of repairing cauda equina fibres with fibrin glue after lumbar fracture and dislocation

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