Fibrin sealant in bone transplantation: No effects on blood flow and bone formation in dogs

A review on endogenous regenerative technology in periodontal regenerative medicine

“…As established in adult mongrel dogs with standardized osteochondral fractures in the left femoral condyle, the physical properties of the bony callus seemed to be enhanced by fibrin sealants [115], suggesting that sealants could potentially be used for healing periodontal bone defects. To study bone formation and regional blood flow following the use of fibrin sealant in autologous cancellous bone transplantation, Lucht et al [116] developed a standardized defect in both tibiae of 18 dogs and then it was filled with an autologous iliac crest graft. On one side, the bone chips were mixed with fibrin sealant while the other side served as control.…”

Fibrin glue: the perfect operative sealant?

“…Clear indications and good success have been noted in patients who undergo osteochondral fracture fixation and repair of ruptured Achilles tendon and in hemophiliacs who undergo orthopedic surgery;30 however, the influence of the material on general bone growth and repair remains uncertain. Lucht et al 38 studied the effect of combining fibrin glue with autologous bone chips for the repair of bony tibia1 defects. Fibrin glue-treated bone sites exhibited less formation of new bone than sites repaired with autologous bone chips alone.…”

Osteoregenerative lateral suboccipital craniectomy using fibrin glue

“…Some authors speculate that the mesenchymal cell stimulation and angiogenic effects of fibrin may enhance osteogenesis or osteo-induction [26]. At the same time, however, several studies report seeing no osteopromotive effect of xenogeneic fibrin glue in animals [7,8,14,27,32]. It is possible that the results of these experiments were affected by the host immune reaction to xenogeneic protein [30], a problem that is not incurred with the application of allogenic fibrin in humans [24,29].…”

“…We had long been using fibrin glue in lateral suboccipital craniectomy to prevent cerebrospinal fluid leakage from the mastoid air cells. An unexpected observation on CT scan, that bone fragments applied with the fibrin glue on the dural surface regrew a bone plate several months later, drew our attention to the possibility that allogenic fibrin glue could have an osteopromotive effect, even though such effects have not been seen using xenogeneic fibrin glue in animals [7,8,14,32]. This observation prompted the present study to test regeneration of bone following regrafting of bone fragments with allogenic fibrin glue in patients.…”