Fibrin sealant in prevention of flexor tendon adhesions: An experimental study in the rabbit

Frykman, Eva; Jacobsson, Staffan; Widenfalk, Bertil

doi:10.1016/0363-5023(93)90248-2

Cited by 62 publications

(39 citation statements)

References 14 publications

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“…6 It is therefore considered that if an intrinsic response could be stimulated at the early stage of tendon healing, the outcome of tendon repair would be preferable with regard to reducing peritendinous adhesion. Based on this idea, a wide range of substances, including fibrin sealant, 11 5-fluorouracil, 12 sodium hyaluronate, 15 aprotinin, 16 and TGF-␤1 neutralizing antibody, 17 have been experimentally applied to the tendon repair, with the aim of reducing extrinsic healing and stimulating the intrinsic mechanism. However, problems such as high cost of raw materials, potential side effects, and limited bioavailability have prevented widespread clinical use of these agents.…”

Section: Discussionmentioning

confidence: 99%

Modulation of peritendinous adhesion formation by alginate solution in a rabbit flexor tendon model

Namba

Shimada²,

Saito

et al. 2006

J Biomed Mater Res

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To examine the antiadhesive effect of an alginate solution following tendon surgery, unilateral subtotal laceration of the flexor digitorum communis tendon was created in one hind limb while the other side was left intact in 32 Japanese white rabbits. The lesion was coated with alginate solution in 16 animals and not coated in the other 16. Degree of adhesion formation was assessed histologically and biomechanically by measuring the flexion angle of the first toe when the flexor digitorum tendon was pulled with a specified force at 4 weeks postoperatively. When compared with the control group, the alginate-treated group demonstrated significantly greater toe flexion, with less scar tissue formation at the repair site. Histologically, complete tendon healing with longitudinal remodeling of collagen fibers was observed in the alginate-treated group, while a random pattern of fibers was observed in the control group. Reduction in adhesion formation using alginate solution represents a novel strategy for the management of tendon injury and repair in the clinical setting.

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Section: Discussionmentioning

confidence: 99%

Modulation of peritendinous adhesion formation by alginate solution in a rabbit flexor tendon model

Namba

Shimada²,

Saito

et al. 2006

J Biomed Mater Res

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“…vascular endothelial cells, fibroblasts and stem cells) not usually seen in healthy tendons [107]. These cells could dominate endogenous TCs, especially with respect to cellular secretome, resulting in compromised functionality [118] and adhesion formation that are associated with pain and locomotion issues [119]. As a result of these changes, mechanical, structural, biochemical and biological properties of the healed tendon never match those of the tissue prior to injury [64].…”

Section: Tendon Healingmentioning

confidence: 99%

“…The utilisation of fibrin has been advocated based on its high cytocompatibility, biodegradability, controllable cross-linking, carrier capacity and presence of several ECM proteins, such as fibronectin, that enhance cell adhesion and proliferation [132][133][134]. Preclinical analysis revealed that fibrin glue around the suture site enabled rabbit flexor tendon healing with smooth gliding surface and without formation of adhesions [119].…”

Section: Minimally Invasive Strategies For Small Tendon Injuriesmentioning

confidence: 99%

The past, present and future in scaffold-based tendon treatments

Lomas

Ryan

Sorushanova

et al. 2015

Advanced Drug Delivery Reviews

183

188

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“…As hence, the rupture of this tendon is very frequent and begins to disrupt after 3% increase in length and will rupture when it is about 8% [3,4] . The ideal tendinous repair must besides morphological reconstitute the injured tissue and preserve the sliding function of the tendon [9] , helping to maintain the movement capacity and regain the tensile strength [3,7,8] Despite of frequent application of TENS to subside the clinical inflammatory signs in human athletes and even companion animals referred cases , there is controversy about the actual positive effect of TENS in healing of tendinous tissue and increasing its tensile strength in human and animal cases [5,14] , that is why we investigated the ultimate strength to failure point and the pattern and effect of TENS on repair of severely traumatized tendon and its gained tensile strength too between two groups.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Tensile Strength of the Superficial Digital Flexor Tendon in Horses Subjected to Transcutaneous Electrical Neural Stimulation Therapeutic Regimen

Sharifi¹,

Kazemi²,

Latifi³

2009

American J. of Applied Sciences

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Abstracts:We would like to sincerely express our gratitude to the university of Tehran and faculty of veterinary medicine research council for approval and financial support for this extensive evaluation of tensile strength of the superficial digital flexor tendon in horses subjected to Transcutaneous Electrical Neural Stimulation (TENS) therapeutic regimen Problems statement: The purpose of this study was to determine the effect of TENS on the tensile strength of experimentally traumatized SDFT in horses. Approach: Eight adult castrated horses between 4-9 years-old and 310-395 Kg body-weight were considered. The left fore-limb superficial digital flexor tendon of each horse was splitted longitudinally in the middle portion in full thickness of 10 cm in length using B.P. blade (15 Times strike), then the connective tissue and skin were approximated using No 2 Nylon. Horses were divided into two groups of control and treated with 4 horses each. No treatment was given to control one, whereas treated group was subjected to the transcutaneous electrical neural stimulation (Newtens 900c) therapeutic regimens10 min daily with intensity of 80 µs, 100 Hz frequency for 14 days. After 60 days, the full length of SDFT (20 cm) was removed from the right normal countralaleral and left traumatized tendon of control and treated limbs of all horses to be subjected to test of tensile strength using Zwick/Roell MDTL Machine with speed of 0.07 mM sec −1 having Proportional Integral Deferential (PID)controller. In assessing the variation obtained data was analyzed using paired-t-test. Results: Data of the tensile strength was revealed an average 0.6625 KN for normal SDFT, 0.6375 KN for treated tendon and 0.6175 KN for control tendon .There was significant improvement in regaining tensile strength in treated tendons comparison to control ones in Conclusion: TENS significantly accelerated healing and remodeling of traumatized tendon to regain its tensile strength.

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Fibrin sealant in prevention of flexor tendon adhesions: An experimental study in the rabbit

Cited by 62 publications

References 14 publications

Modulation of peritendinous adhesion formation by alginate solution in a rabbit flexor tendon model

Modulation of peritendinous adhesion formation by alginate solution in a rabbit flexor tendon model

The past, present and future in scaffold-based tendon treatments

Evaluation of Tensile Strength of the Superficial Digital Flexor Tendon in Horses Subjected to Transcutaneous Electrical Neural Stimulation Therapeutic Regimen

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