Modulation of peritendinous adhesion formation by alginate solution in a rabbit flexor tendon model

Abstract

To examine the antiadhesive effect of an alginate solution following tendon surgery, unilateral subtotal laceration of the flexor digitorum communis tendon was created in one hind limb while the other side was left intact in 32 Japanese white rabbits. The lesion was coated with alginate solution in 16 animals and not coated in the other 16. Degree of adhesion formation was assessed histologically and biomechanically by measuring the flexion angle of the first toe when the flexor digitorum tendon was pulled with a specified force at 4 weeks postoperatively. When compared with the control group, the alginate-treated group demonstrated significantly greater toe flexion, with less scar tissue formation at the repair site. Histologically, complete tendon healing with longitudinal remodeling of collagen fibers was observed in the alginate-treated group, while a random pattern of fibers was observed in the control group. Reduction in adhesion formation using alginate solution represents a novel strategy for the management of tendon injury and repair in the clinical setting.

Dual functional core–sheath electrospun hyaluronic acid/polycaprolactone nanofibrous membranes embedded with silver nanoparticles for prevention of peritendinous adhesion

“…The PIP and DIP joint range-of-motion assays were evaluated due to their physiological and clinical relevance [44,45]. There was a statistical improvement (i.e., an increase) in the DIP joint flexion (Fig.…”

Preparation and characterization of antiadhesion barrier film from hyaluronic acid-grafted electrospun poly(caprolactone) nanofibrous membranes for prevention of flexor tendon postoperative peritendinous adhesion

“…More physiologically and clinically relevant PIP and DIP joint range-of-motion assays were used in the study. 38,39 Compared with the control group, the experimental groups showed a statistical improvement (ie, an increase in value) in DIP joint-flexion angle ( Figure 8A), PIP joint-flexion angle ( Figure 8B), and sliding excursion ( Figure 8C). However, only the PCL-g-HA NFM restored the values to those of the normal unoperated FDP tendons (dotted lines in Figure 8).…”

Effects of a Single Application of Adcon Gel on Peritendinous Adhesion: An Experimental Study in Rabbits

“…Numerous materials and agents have been used as a mechanical barrier to envelop sutured tendons in attempts to minimize the adhesion formation after primary tendon repair. Currently, the modalities used for preventing adhesions without affecting the healing process include; human amniotic fluid, hyaluronic acid, alginate solution, mannose-6-phosphate, 5-fluorouracil, injection of growth factors or platelet concentrate, local application of extracorporeal shock wave therapy or ultrasound therapy, local injection of bone-marrow-derived mesenchymal stem cells, systemic administration of antiinflammatory drugs [7][8][9][10][11][12][13][14][15][16] . The use of a barrier during surgery to protect raw tissue surfaces has been shown to be one of the most effective methods of preventing tendon adhesions.…”