Fibrin sealants in surgical or traumatic hemorrhage

Schexneider, Katherine I.

doi:10.1097/01.moh.0000142104.21058.df

Cited by 24 publications

(14 citation statements)

References 26 publications

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“…Fibrin sealant has been used extensively in all surgical disciplines for tissue adhesion, suture support, hemostasis, wound care, and endoscopic treatment of bleeding [20][21][22][23][24]. Cyanoacrylate based glues have been investigated in numerous scientific studies as hemostatic agents, topical dressing, and adhesives in soft tissues, in ophthalmology, odontostomatology, osteosynthesis of bone fracture and, recently, as drug carriers [25][26][27][28].…”

Section: Discussionmentioning

confidence: 99%

Cyanoacrylate Surgical Glue as an Alternative to Suture Threads for Mesh Fixation in Hernia Repair

Losi

Burchielli

Spiller

et al. 2010

Journal of Surgical Research

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Section: Discussionmentioning

confidence: 99%

Cyanoacrylate Surgical Glue as an Alternative to Suture Threads for Mesh Fixation in Hernia Repair

Losi

Burchielli

Spiller

et al. 2010

Journal of Surgical Research

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“…Crosseal contains human fibrinogen and thrombin, and lacks the bovine aprotinin component found in the other fibrin sealants. [14]…”

Section: Fibrin Sealantsmentioning

confidence: 99%

Evolution of hemostatic agents in surgical practice

Sundaram

Keenan

2010

Indian J Urol

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Objective:Topical hemostatic agents are used in a wide variety of surgical settings, and the evolution of this class of surgical tools is an interesting topic. We reviewed and outlined the historical progress of topical hemostats into present day surgery and urology, and highlight opportunities for future research.Materials and Methods:A MEDLINE search of all available literature concerning several classes of topical hemostatic agents was performed. Fibrins sealants, Gelatin sponge hemostatics, cyanoacrylate adhesives, oxidized regenerated cellulose, and microfibrillar collagen were included. References were chosen from a broad range of surgical literature.Results:Topical hemostatic agents have historically taken advantage of a wide variety of mechanisms for hemostasis. Fibrin sealants have a rich history and large potential for further applications. Gelatin sponge hemostatics have been widely used since their introduction, but have changed little. Cyanoacrylate adhesives have a unique mechanism and opportunity for novel applications of existing products. Oxidized cellulose was original in the use of plant-based components. Microfibrillar collagen hemostats have evolved to a wide variety of formats.Conclusions:A review of the evolution of topical hemostatic agents highlights opportunities for potential novel research. Fibrin sealants may have the most opportunity for advancement, and understanding the history of these products is useful. With the drive in urology for minimally invasive surgical techniques, adaptation of topical hemostatic agents to this surgical approach would be valuable and offers an opportunity for novel contributions.

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“…Given an excess amount of amine over NHS ester (molar ratio [ 19), the hydrogel was likely formed by chemical crosslinking of PAA with PEG as a polymer crosslinker. This is consistent with the FTIR results showing PAA-like spectra of the hydrogels.…”

Section: General Hydrogel Formation and Characteristicsmentioning

confidence: 99%

“…A typical example is a fibrin sealant, which is formed instantaneously from mixing liquid forms of fibrinogen and thrombin. Such sealant is widely used in different surgical procedures, including hemostasis, wound healing, suture support, and tissue sealing 3, 19…”

Section: Introductionmentioning

confidence: 99%

Experimental optimization of an in situ forming hydrogel for hemorrhage control

2008

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The fabrication of a novel in situ forming hydrogel composed of a multifunctional poly(ethylene glycol) (PEG) N-hydroxysuccinimide ester (NHS) and poly(allylamine hydrochloride) (PAA) was investigated. FTIR confirmed that PAA formed the hydrogel matrix (i.e., the formation of a PAA-like hydrogel). A factorial experiment was conducted to identify the key parameters that controlled gelation time, gel content, and swelling properties. The type of PEG (e.g., 4- and 6-arm) appeared to play a major role in determining all three performance parameters, with the greatest effect on gelation time. Other influencing factors include (a) the PEG concentration, which contributes to the gelation time and gel content; (b) pH of the buffer used for dissolving each polymer, which can affect the gelation time; and (c) PAA molecular weights, which contribute to the gel content and swelling. The concentration of PAA solution had no significant effects on hydrogel formation and properties within the investigated range, presumably due to negligible changes in the crosslinking density of the hydrogels. The PAA buffer pH influenced the gel content as well. Finally, thromboelastography was used to examine the effects of each polymer and their in situ gelation on blood coagulation in vitro. All individual polymers tested reduced clot strength, while the gelation of the polymers enhanced overall procoagulant effects. These results suggest that the biomaterial can be optimized to provide a combination of rapid gelation and swelling properties suitable for hemorrhage control and thus warrant further studies in animal bleeding models.

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Fibrin sealants in surgical or traumatic hemorrhage

Cited by 24 publications

References 26 publications

Cyanoacrylate Surgical Glue as an Alternative to Suture Threads for Mesh Fixation in Hernia Repair

Cyanoacrylate Surgical Glue as an Alternative to Suture Threads for Mesh Fixation in Hernia Repair

Evolution of hemostatic agents in surgical practice

Experimental optimization of an in situ forming hydrogel for hemorrhage control

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