Fibrinogen and factor VII in male neonates

Salm, Paulien van der; Ubachs, Hans M. H.; Wersch, J. W. J. Van

doi:10.1016/0049-3848(94)90102-3

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…5 When compared with male newborns, significantly higher levels of coagulation factor VII were reported in female newborns, who also showed a trend to increased levels of coagulation factor VIII. 29 However, confirming other data, we found no gender-related changes in ROTEM w parameters during childhood. 9 Excluding all children ,4 months, overall Kruskal-Wallis's test revealed no significant changes for all ROTEM w parameters.…”

Section: Discussionsupporting

confidence: 90%

Thromboelastometry (ROTEM®) in children: age-related reference ranges and correlations with standard coagulation tests

Oswald

Stalzer

Heitz

et al. 2010

British Journal of Anaesthesia

160

129

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Key points † Monitoring whole-blood coagulation using viscoelasticity assays is useful in managing perioperative bleeding. † This observational study compared thromboelastometry [ROTEM w ] assays with standard coagulation tests in 359 children in six age groups. † Age-dependent differences identified in both standard and ROTEM w assays provide important reference ranges for monitoring paediatric surgical patients.Background. The small sample volume needed and the prompt availability of results make viscoelastic methods like rotational thromboelastometry (ROTEM w ) attractive for monitoring coagulation in small children. However, data on reference ranges for ROTEM w parameters in children are scarce.Methods. Four hundred and seven children (ASA I and II) undergoing elective surgery were recruited for this prospective, two-centre, observational study. Subjects were grouped as follows: 0-3, 4 -12, 13 -24 months, 2-5, 6-10, and 11-16 yr. Study objectives were to establish age-dependent reference ranges for ROTEM w assays, analyse age dependence of parameters, and compare ROTEM w data with standard coagulation tests.Results. Data from 359 subjects remained for final analysis. Except for extrinsically activated clot strength and lysis, parameters for ROTEM w assays were significantly different among all age groups. The most striking finding was that subjects aged 0-3 months exhibited accelerated initiation (ExTEM coagulation time: median 48 s, Q1-Q3 38 -65 s; P¼0.001) and propagation of coagulation (a angle: median 78 o , Q1-Q3 69-84 o ; P,0.001) and maximum clot firmness (median 62 mm, Q1-Q3 54-74 mm), although standard plasma coagulation test results were prolonged (prothrombin time: median 13.2 s, Q1-Q3 12.6 -13.6 s; activated partial thromboplastin time: median 42 s, Q1-Q3 40-46 s). Lysis indices of ,85% were observed in nearly one-third of all children without increased bleeding tendency. Platelet count and fibrinogen levels correlated significantly with clot strength, and fibrinogen levels correlated with fibrin polymerization.Conclusions. Reference ranges for ROTEM w assays were determined for all paediatric age groups. These values will be helpful when monitoring paediatric patients and in studies of perioperative coagulation in children.Viscoelastic coagulation tests have gained a renewed interest in the safe management of surgery-or trauma-induced coagulopathy in adult and paediatric patients. 1 -4 Viscoelastic whole-blood analyses, such as thromboelastography (TEG w ) and thromboelastometry (ROTEM w ), reflect initiation and propagation of coagulation, fibrinogen/fibrin -platelet interaction, and clot lysis. In 1997, the ROTEM w device was introduced into clinical routine at our institution. A multicentre study published by Lang and colleagues 5 presented reference ranges for ROTEM w assays for adults aged 17-85 yr. With the exception of some data referring to preterm neonates, newborns, and children exhibiting cardiac failure, reference data are scarce for paediatric patients. 6 -10 The main objective of ...

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Section: Discussionsupporting

confidence: 90%

Thromboelastometry (ROTEM®) in children: age-related reference ranges and correlations with standard coagulation tests

Oswald

Stalzer

Heitz

et al. 2010

British Journal of Anaesthesia

160

129

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“…However, weight at 1 year was associated with a reduction in mean plasma fibrinogen and factor VII concentrations, 36 but this finding was not confirmed in other studies. 37,38…”

Section: Coagulopathymentioning

confidence: 99%

Intrauterine Growth, the Vascular System, and the Metabolic Syndrome

Holt¹,

Byrne²

2002

Seminars in Vascular Medicine

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There is substantial evidence linking birth size with the risk of developing cardiovascular disease and its major biological risk factors in adulthood. The fetal origins hypothesis proposes that these diseases originate through adaptations, which the fetus makes when it is undernourished. These adaptations may be cardiovascular, metabolic, or endocrine. They permanently change the structure and function of the body. Prevention of the diseases may depend on prevention of imbalances in fetal growth or imbalances between prenatal and postnatal growth, or imbalances in nutrient supply to the fetus. The purpose of this article is to examine some of the more recent epidemiological associations between low birth weight and adult atherosclerotic vascular disease and its risk factors. We will also discuss mechanisms that might explain these associations.

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State-of-the-Art Review: Usefulness of Laboratory Techniques for Evaluating Antithrombotic Efficacy of New Therapeutic Strategies

Amiral¹

1995

Clin Appl Thromb Hemost

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New drugs and new therapeutic strategies are being introduced for the prevention and the management of cardiovascular and thromboembolic disorders. Extensive clinical studies and large-scale epidemiological investigations are conducted to demonstrate the efficacy of these therapeutic approaches. Laboratory assays are invaluable tools for this exploration. We discuss how the new understanding concerning the regulation of the coagulolytic equilibrium offers novel investigation tools. Parameters reflecting the activities of new drugs targeted to their impact site and presenting few side effects are available. In addition to global clotting methods and chromogenic substrate-based assays, introduction of immunoassays has allowed measurement of most of the molecular markers of hemostatic activation. We recommend use of a panel of markers exploring the endothelial damage, the blood cell involvement, the early coagulant pathways' activation (XIIa and VIIa), the thrombin-formation pathways, the fibrin formation, and the evaluation of the global fibrinolytic capacity. When related to the clinical end points, all these laboratory assays offer useful and reliable monitoring of new drugs. They contribute to the establishment of new therapeutic strategies. Key Words: Hemostasis—Activation—Antithrombotic—Therapy— Laboratory monitoring.

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Fibrinogen and factor VII in male neonates

Cited by 3 publications

References 16 publications

Thromboelastometry (ROTEM®) in children: age-related reference ranges and correlations with standard coagulation tests

Thromboelastometry (ROTEM®) in children: age-related reference ranges and correlations with standard coagulation tests

Intrauterine Growth, the Vascular System, and the Metabolic Syndrome

State-of-the-Art Review: Usefulness of Laboratory Techniques for Evaluating Antithrombotic Efficacy of New Therapeutic Strategies

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