A single dose fluconazole is as safe and effective as a single dose of miconazole.

Summary: Coagulation and fibrinolysis activation have been investigated in fifty-eight women with recently detected gynaecological tumours. Twenty-six were benign and 32 malignant: of the last group nine patients had metastases. A control group consisted of 31 age-matched healthy women. Prothrombin fragment 1 + 2, thrombinantithrombin III and D-dimer were measured. The median values of all analytes were significantly higher in the malignant tumour group, but not in the benign tumour group, as compared to the control group. The group of patients with a gynaecological tumour and metastases differed from the non-metastasized tumour group in prothrombin fragment 1-1-2, thrombin-antithrombin III and D-dimer. In the non-metastasized malignant tumour group solely prothrombin fragment 1 + 2 was significantly higher than in the benign tumour group. Coagulation and fibrinolysis appeared to be activated in the patients with a metastasized gynaecological tumour, fibrinolysis predominating as can be derived from the elevated D-dimer/thrombin-antithrombin III and D-dimer/prothrombin fragment 1 + 2 ratios. The studied constituents do not enable a differentiation between the benign and malignant processes. However, as the differences of these values in both malignant tumour groups were significant, this might be used to trace the existence of metastases in gynaecological tumours. Investigation of these analytes in several specific types of gynaecological tumours might be clinically relevant.

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Since smoking is known to influence hemostasis, the possible impact of maternal smoking on hemostatic variables in the newborn was studied. Cord blood clotting factors fibrinogen, factor VII, factor VIII:c and factor XIII were measured in 151 newborns. A significant reduction in birth weight and a rise in the placental/birth weight ratio was found in newborns of smoking mothers, which is in agreement with the literature. No differences in cord blood clotting factors were found between the smoking and non-smoking groups. A possible explanation for this, at least for lack of difference in fibrinogen levels, may be that fetal lungs were not directly exposed to smoke.

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