Fibrinogen, Factor VIII Related Antigen, Antithrombin III and α2-Antiplasmin in Peripheral Arterial Disease

Christe, M; Delley, A; Marbet, G A; L, Biland; Duckert, F

doi:10.1055/s-0038-1661187

Cited by 22 publications

(4 citation statements)

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“…Previous reports have noted that both rheological (Dormandy et al, 1973;Stormer et al, 1974;Kallero et al, 1981;Lowe et al, 1986;Ernst & Matrai, 1988;Lowe et al, 1993) and haemostatic factors (Christe et al, 1984;Donaldson et al, 1987;Al-Zahrani et al, 1992;Fowkes et al, 1993;Lassila et al, 1993;Smith et al, 1993;Cortellaro et al, 1994;Herren et al, 1994;Heinrich et al, 1995;Lee et al, 1995) are elevated in persons with peripheral arterial disease. However, few have investigated the possible confounding by smoking, or whether there is an association with leg ischaemia in the presence of a given degree of atherosclerotic stenosis with the exception of the Edinburgh Artery Study .…”

Section: Discussionmentioning

confidence: 96%

Haemostatic and rheological factors in intermittent claudication: the influence of smoking and extent of arterial disease

et al. 1996

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Patients with intermittent claudication have been reported to have disturbances in blood rheology and haemostasis. Whether these disturbances are a result of, or largely independent of, smoking history and arterial narrowing has not yet been established. The levels of whole blood and plasma viscosity, haematocrit, von Willebrand factor antigen, fibrin D-dimer antigen and urinary fibrinopeptide A antigen were compared in 617 claudicants and 722 controls from two epidemiological studies in Edinburgh. After adjustment for age and sex, all factors, except whole blood viscosity and haematocrit, were significantly higher in the claudicants compared to controls (P < or = 0.001). The risk of intermittent claudication was significantly raised for unit change in each factor, except for whole blood viscosity and haematocrit. Adjustment for lifetime smoking had little effect on the odds ratios. After further adjustment for the ankle brachial pressure index (as a measure of the extent of peripheral arterial disease), haematocrit, von Willebrand factor and urinary fibrinopeptide A showed a significant independent relationship with the risk of intermittent claudication. We conclude that the association between selected rheological and haemostatic factors and leg ischaemia is largely independent of both smoking history and the extent of arterial narrowing, and may be directly related to microvascular ischaemia.

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Section: Discussionmentioning

confidence: 96%

Haemostatic and rheological factors in intermittent claudication: the influence of smoking and extent of arterial disease

et al. 1996

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“…obesity (25),h ypercholesterolaemia (26),smoking (27,28) and hypertension (29,30) (Table 2). The finding of raised vWf in atherosclerosis (6) has also beensupported and extendedtoall typesofcardiovasculardisease, includingperipheral disease (27,31), angina,acutem yocardialinfarction and coronarteryaryartery disease (32),stroke (33) and atrial fibrillation (34).…”

Section: Vonwillebrand Factorinhumandiseasementioning

confidence: 94%

Plasma von Willebrand factor, thrombosis, and the endothelium: The first 30 years

Blann¹

2006

Thromb Haemost

162

135

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Summary “It is quite useless to argue the questions concerning the development of intimal scleroses if we study and discuss the late stages of the disease alone. If we wish to gain insight into the complex question of arterio-sclerosis we must attempt to follow the lesion from its earliest beginning” (Klotz and Manning, J Path Bact 1911: 16; 211–20).Over thirty years ago Boneu and colleagues publisheda report of raised levels of plasma vonWillebrand factor (vWf) in patients with arteritis, diabetes and sepsis. They concluded that raised levels of this molecule indicate endothelial damage, and may possibly be a contributory factor in thrombosis in arterial disease. The former aspect of this conclusion is now accepted, and numerous studies on the risk factors for atherosclerosis provide mechanisms for this damage. Other studies have demonstrated raised levels in cancer and in connective tissue disease. Numerous long-term follow-up studies have also demonstrated that increased vWf predicts major cardiovascular end points. However, the link between these studies, and the latter aspect of Boneu’s conclusion, that raised vWf contributes to thrombosis is,although attractive, nevertheless unproven. Despite this, vWf remains the most important plasma marker of endothelial damage/dysfunction and as such attracts clinical attention.

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“…Subjects with claudication have consistently demonstrated elevated plasma levels of several hemostatic and rheologic factors, including fibrinogen and plasma viscosity. [8][9][10][11][12] In addition, the severity of lower limb atherosclerosis, as…”

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confidence: 99%

Smoking, hemorheologic factors, and progression of peripheral arterial disease in patients with claudication

Smith

Lowe

Lee

et al. 1998

Journal of Vascular Surgery

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Fibrinogen, Factor VIII Related Antigen, Antithrombin III and α2-Antiplasmin in Peripheral Arterial Disease

Cited by 22 publications

References 1 publication

Haemostatic and rheological factors in intermittent claudication: the influence of smoking and extent of arterial disease

Haemostatic and rheological factors in intermittent claudication: the influence of smoking and extent of arterial disease

Plasma von Willebrand factor, thrombosis, and the endothelium: The first 30 years

Smoking, hemorheologic factors, and progression of peripheral arterial disease in patients with claudication

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