Fibrinogen Levels and Total Serum Bile Acids in Intrahepatic Cholestasis of Pregnancy

Özgen, Levent; Özgen, Gülten; Karaşin, Süleyman Serkan; Bayram, Feyza

doi:10.29271/jcpsp.2022.11.1404

J Coll Physicians Surg Pak

2022

DOI: 10.29271/jcpsp.2022.11.1404

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Fibrinogen Levels and Total Serum Bile Acids in Intrahepatic Cholestasis of Pregnancy

Levent Özgen

Gülten Özgen

Süleyman Serkan Karaşin

et al.

Abstract: Objective: To determine the role of complete blood count and coagulation function factors as inflammatory markers in intrahepatic cholestasis of pregnancy (ICP).

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2024

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Adverse Pregnancy Outcomes and Prognostic Factors in Hepatitis B Virus Patients with Intrahepatic Cholestasis During Pregnancy

Zhang,

Wei,

Zhao

et al. 2024

Clin. Exp. Obstet. Gynecol.

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Background: We conducted this study to investigate adverse pregnancy outcomes of hepatitis B virus infection coexistng with intrahepatic cholestasis in pregnant women, along with identifying associated risk factors. Methods: We retrospectively collected study data from Beijing Youan Hospital in China spanning January 2014 to December 2021. The study included 220 patients, divided into two groups: Group I consisted of 110 patients with hepatitis B virus infection and intrahepatic cholestasis during pregnancy, while Group II comprised 110 patients with hepatitis B virus infection alone. Maternal demographics, laboratory values, obstetric complications, and adverse pregnancy outcomes were collected and analyzed between Groups I and II. To investigate the features of hepatitis B virus infection with intrahepatic cholestasis in pregnancy patients further, we also evaluated risk factors of adverse pregnancy outcomes in Group I. Results: Adverse pregnancy outcomes, including preterm birth (<37 weeks (w)), postpartum hemorrhage, meconium-stained amniotic fluid, neonatal asphyxia, neonate intensive care unit admission and small for gestational age rates were significantly increased for Group I compared with Group II (p < 0.05). In hepatitis B virus infection patients with intrahepatic cholestasis during pregnancy, elevated total serum bile acids independently correlated with six adverse pregnancy outcomes. Conclusions: Pregnant patients with both hepatitis B virus infection and intrahepatic cholestasis experienced a higher occurrence of adverse pregnancy outcomes compared to those with Hepatitis B virus infection alone. Total serum bile acids were an independent risk factor for adverse pregnancy outcomes in Hepatitis B virus infection with intrahepatic cholestasis during pregnancy. Clinical Trial Registration: The study was registered with https://classic.clinicaltrials.gov/ (no.: zx10201201).

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Adverse Pregnancy Outcomes and Prognostic Factors in Hepatitis B Virus Patients with Intrahepatic Cholestasis During Pregnancy

Zhang,

Wei,

Zhao

et al. 2024

Clin. Exp. Obstet. Gynecol.

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Fibrinogen Levels and Total Serum Bile Acids in Intrahepatic Cholestasis of Pregnancy

Abstract: Objective: To determine the role of complete blood count and coagulation function factors as inflammatory markers in intrahepatic cholestasis of pregnancy (ICP).

Cited by 1 publication

References 3 publications

Adverse Pregnancy Outcomes and Prognostic Factors in Hepatitis B Virus Patients with Intrahepatic Cholestasis During Pregnancy

Adverse Pregnancy Outcomes and Prognostic Factors in Hepatitis B Virus Patients with Intrahepatic Cholestasis During Pregnancy

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