Fibrinogen Levels in Hypertensive and Normotensive: A Cross-Sectional Study from El-Obied City, Sudan

Abstract

Hypertension (HTN) has been defined as a blood pressure level at which an otherwise healthy person would have an increased risk of cardiovascular disease that could be mitigated through blood pressure-lowering treatment. Worldwide, hypertension is one of the most common causes of death. The prevalence of hypertension and cardiovascular disease increases with age, and has been found to be higher in those of South Asian and African ancestry, and in Aboriginal populations. Hypertension is not only one of the most important risk factors for cardiovascular disease, but also the number one modifiable risk factor for stroke. Alterations in blood coagulation system have been reported in patients of hypertension. Fibrinogen has been identified as a major independent risk factor for cardiovascular diseases. This was a descriptive cross-sectional study, conducted in Elobied teaching hospital during period from March to June 2014. The aim of this study is to determine the level of fibrinogen among hypertensive patients. Seventy percent of the patients (about 35 patients) had high fibrinogen level above 400 mg/dl compared with the control and about 30% (15 patients) were within the normal range of 200 mg-400 mg/dl. This study has concluded that there was a significant increase in fibrinogen level in hypertensive patients compared to control, while the gender has no effect on the level of fibrinogen.

Determination of Prothrombin Time, Activated Partial Thromboplastin Time and D-Dimer Levels among Malaria Infected Patients in Sinnar State, Sudan

“…Also Das et al, find prolonged PT, prolonged APTT in 80%, 70% out of 40 cases (p < 0.05 in both parameters) [15]. Our result shows no statistically significant in PT, APTT and D-dimer between male and female, this finding agrees with study conducted by Agab Eldour et al and they concluded gender had no effect on the level of fibrinogen [16].…”

Alteration in prothrombin time, INR, partial thromboplastin time and platelets in type 2 diabetes mellitus, cross-sectional study- Sudan

“…Numerous studies have shown that coagulation abnormalities occur in the course of diabetes mellitus, resulting in a state of thrombophilia [5]. In Sudan there are many studies conducted about evaluation of coagulation impairment and mechanism of changing about liver disease, hypertension and pregnancy, and few studies among diabetic, the affect among patient with liver disease were clearly significant [20,21,22,23], but in diabetes some studies found significant and other not, till now the hemostatic impairment it does not clear till now. The major limitations of our study are the sample size and duration of the study.…”

Comparison between 5 mg and 10 mg warfarin loading doses therapy in cardiac care unit patients at Elobied Hospital, Elobied City- Sudan

“…Plasma was separated from cells into plane container. PPP will be stored and refrigerated on (2 -8 c) and tested within 4 hours [7]. Prothrombin time and INR were measured at baseline and then after 72 hours by Coagulometer semi-automated (Urit 610).…”