Fibrinogen-to-albumin ratio may be a predictor for ascending aortic aneurysm

Abstract

OBJECTIVE:The predictive value of the fibrinogen-to-albumin ratio has been evidenced in coronary artery disease. Available data demonstrated that inflammation and oxidative stress are the relevant mechanisms of ascending aortic aneurysm formation and dilatation.The fibrinogen-to-albumin ratio reflects oxidative stress and inflammation. This study investigated the correlation between fibrinogento-albumin ratio and ascending aortic aneurysm.METHODS: A total of 250 consecutive patients with ascending aortic aneurysm and 250 consecutive patients with normal ascending aortic diameter were included in the study using comprehensive transthoracic echocardiography. All data and fibrinogen-to-albumin ratio were compared between two groups. RESULTS:The fibrinogen-to-albumin ratio levels were significantly higher in ascending aortic aneurysm group compared with normal ascending aortic diameter group (p<0.001). Also, there was significantly positive correlation between the diameter of the ascending aorta and the fibrinogen-to-albumin ratio (p<0.001).CONCLUSION: Fibrinogen-to-albumin ratio is associated with ascending aortic aneurysm and may serve as blood marker for identifying high-risk patients.

Fibrinogen to Albumin Ratio as Early Serum Biomarker for Prediction of Intra-Hospital Mortality in Neurosurgical Intensive Care Unit Patients with Spontaneous Intracerebral Hemorrhage

“…Furthermore, the present study identified a higher fibrinogen to albumin ratio as a novel independent and additional predictor of intrahospital mortality in neurosurgical ICU patients with ICH. The fibrinogen to albumin ratio was commonly identified as a predictor of poor outcome and adverse events in patients with cardiovascular diseases, cancer, sepsis, and stroke, although not in neurosurgical ICU-admitted ICH patients [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. This is the first report on the impact of the fibrinogen to albumin ratio in neurosurgical ICU patients with ICH, and it presents a significant association of intrahospital mortality and a fibrinogen to albumin ratio >0.075 upon admission.…”

“…However, both biomarkers, fibrinogen and albumin, are synthesized in the liver, so the prognostic value of these single biomarkers alone is limited in patients with hepatic insufficiency (e.g., cancer, malnutrition, or chronic heart failure). On this account, a new biomarker, the fibrinogen to albumin ratio, was implemented to determine medical conditions including malnutrition, coagulation system, systemic inflammation, and hepatic insufficiency [ 20 , 21 , 22 , 23 , 24 , 25 , 26 ].…”

“…Nevertheless, the amount and predictive value of the fibrinogen to albumin ratio seems to be dependent on the underlying diseases, as shown by very heterogenous study results [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. Several studies have indicated a correlation of elevated fibrinogen to albumin ratio and poor outcome and the presence of adverse events in patients with cardiovascular diseases, cancer, venoarterial extracorporeal membrane oxygenation, and stroke [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. In contrast, a lower fibrinogen to albumin ratio has predicted 28-day mortality in peritonitis-induced septic patients and is associated with poor overall survival in esophageal small-cell carcinoma patients [ 18 , 19 ].…”

“…A total of 198 patients with a mean age of 68.7 ± 13 years (age range: 33-93 years) were included in this study, of whom 87 (43.9%) were women. Upon admission, a median GCS score of 6.5 (IQR: 3-11), APACHE II score of 18 (IQR: 14-21), NIHSS score of 15 (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25) and mRS score of 5 (3)(4)(5) were observed. Chronic arterial hypertension (60.1%) and cardiac arrhythmia (19.3%) were the most common comorbidities.…”

“…Inflammation and acute stress are important elements of the pathophysiology pathway of acute ICH and secondary brain injury [ 17 ]. The fibrinogen to albumin ratio, as an inflammatory serum biomarker, has been identified in several studies as a predictor of poor outcome and adverse events in patients with cardiovascular diseases, cancer, sepsis, and stroke [ 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 ]. The acute-phase protein fibrinogen is an important part of the coagulation cascade as well as an indicator of systemic inflammation [ 20 , 26 , 27 ].…”