Fibrinolysis therapy achieved with tissue plasminogen activator and aspiration of the liquefied clot after experimental intracerebral hemorrhage: rapid reduction in hematoma volume but intensification of delayed edema formation

Abstract

Despite a significantly accelerated reduction in hematoma volume, the development of delayed perifocal edema was intensified by fibrinolytic therapy, which is probably related to the function of tPA as a mediator of edema formation after thrombin release and ischemia. Further experimental and clinical investigations are required to establish the future role of fibrinolysis in the management of SICH.

Comparison of Spontaneous Intracerebral Hemorrhage Treatment in Germany Between 1999 and 2009

“…18 Furthermore, stereotactic aspiration and fibrinolysis in the treatment of deep-seated intracerebral hemorrhage achieved satisfactory morphological results 19 but could not improve the patient's outcome significantly. [20][21][22] With regard to these findings, the results of our survey are interesting. The high response rates of the questionnaires were very satisfying and therefore, the study shows a realistic image of neurosurgical practice regarding the treatment of patients with SICH in Germany.…”

Experimental Study of Intracranial Hematoma Detection with Flat Panel Detector C-Arm CT

“…Another group placed a balloon catheter and inflated it within the brain to make a cavity before injecting blood. [5][6][7] We injected the blood sample slowly and continuously through a catheter without creating a cavity in a manner previously described 8 to successfully create 11 ICHs. Some of our ICHs were accompanied by intraventricular and/or subarachnoid hemorrhage (SAH), which was confirmed with necropsy.…”

Local fibrinolysis in surgical treatment of traumatic intracranial hemorrhage

“…Rohde, R.J. Barrett ³ ñï³âàâòîðè [12,31,32] âêàзóâàëè íà мîaeëèâ³ñòü ðåöèäèâóâàííя ãåмàòîм àбî зб³ëüшåííя ¿х ïðè âèêîðèñòàíí³ äëя ËÔ rt-PA â³äïîâ³äíî ó 7,4 òà 13,3% ñïîñòåðåaeåíü, ó òîé aeå чàñ íèмè äîñяãíóò³ ïîзèòèâí³ ðåзóëüòàòè ó âèãëяä³ змåíшåííя îб'ємó ãåмàòîмè â³äïîâ³äíî äî 32,3 òà 17%. R.J. Barrett ³ ñï³âàâòîðè [12] ïðèзíàчàëè rt-PA ïî 2 мã чåðåз êîaeí³ 12 ãîä äî змåíшåííя îб'ємó ãåмàòîмè äî 10 мë ³ мåíшå.…”