Fibrinolytic Activity and Coronary-Artery Disease

Chakrabarti, Ranjan; Hocking, ElizabethD.; Fearnley, G. R.; Mann, Rupinder; Attwell, T.N; Jackson, Dan

doi:10.1016/s0140-6736(68)91104-5

Cited by 131 publications

(29 citation statements)

References 17 publications

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“…42 (6) Coagulation and fibrinolysis: Physiologic imbalance between the haemostatic and fibrinolytic systems have been shown to contribute to the development of CAD. 43,44 Fibrinogen: Prospective studies in Europe and North America demonstrated that elevated plasma fibrinogen levels are an independent risk factor for CVD, particularly CAD and stroke. 45,46 Fibrinogen levels are positively correlated with age, smoking, body mass, serum insulin levels and, LDL cholesterol, and negatively correlated with alcohol intake, physical activity, HDL cholesterol and female sex hormone use.…”

Section: Trends In Cad Inmentioning

confidence: 99%

Trends in coronary artery disease and associated risk factors in sub-Saharan Africans

Akinboboye

Idris²,

Akinkugbe

2003

J Hum Hypertens

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It has been suggested that the prevalence of coronary artery disease (CAD) is steadily increasing in subSaharan Africa. To address this issue, we conducted a Medline search of English language articles on cardiovascular diseasesFand specifically CAD in AfricaF from 1966 to 1997. The prevalence of CAD and related complications is relatively low in most regions in Africa compared to that obtained in the economically developed countries, although the situation is rapidly changing due to trends in urbanization, changes in lifestyle, acquisition of technology and the increasing numbers of tertiary care institutions. There are variations in reported prevalence rates within the different regions, but there is an upward trend in all the regions of the sub-Saharan Africa. This trend is believed to be related to the increasing frequencies of CAD risk factors in the subcontinent.

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Section: Trends In Cad Inmentioning

confidence: 99%

Trends in coronary artery disease and associated risk factors in sub-Saharan Africans

Akinboboye

Idris²,

Akinkugbe

2003

J Hum Hypertens

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“…In 1968 Chakrabarti et al [2] reported that coronary ischaemic processes involve a fibri nolytic hypofunction that could promote isch aemic disorders. This was later confirmed by other authors [3,4], Later, three separate groups [5][6][7] have attributed this fibrinolytic hypofunction to an increase in PAI activity which was later identified as PAI-1 [8].…”

Section: Pai-1 Levels In Heart Diseasementioning

confidence: 99%

Role of Plasminogen Activator Inhibitor Type 1 in the Pathogenesis of Coronary Artery Diseases

Aznar¹,

Estellés²

1994

Pathophysiol Haemos Thromb

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Patients with ischaemic heart disease have high levels of plasminogen activator inhibitor type 1 (PAI-1). These levels can constitute an independent thrombotic risk factor. In addition, PAI-1 synthesis is greater in the atherosclerotic vessels than in the normal vessels and this can also constitute an atherogenic risk factor. There is a good correlation between insulinaemia and PAI-1, but it has not been demonstrated that the circulating level of PAI-1 depends exclusively on insulinaemia. The increased levels of PAI-1 correlate with other coronary risk factors, especially hypertriglyceridaemia, but high PAI-1 levels are also found in normolipaemic patients. Vascular synthesis of PAI-1 can be promoted by high levels of circulating lipoprotein a. Finally, an exercise programme can increase the fibrinolytic activity of heart disease patients towards normal.

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“…While abnormalities of fibrinolysis, both at rest [1][2][3][4][5] and following exercise or venous occlusion [5][6][7][8][9], have been recorded in pa tients with coronary artery disease, the large epidemiological, prospective studies of fibri nolysis in middle-aged men have so far failed to show a relationship between defective fi brinolysis and the development of cardio vascular events [10,11 ]. A role for fibrinoly sis in the development of coronary artery disease is, therefore, unproven.…”

Section: Introductionmentioning

confidence: 99%

Severity of Coronary Artery Disease and Basal Fibrinolysis

Small

Lowe²,

Beattie³

et al. 1987

Pathophysiol Haemos Thromb

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Basal venous blood levels of several components of the fibrinolytic enzyme system (plasminogen activator, plasminogen, fibrin degradation products, α₂-antiplasmin, and α₂-macroglobulin) were measured in 100 white men with angiographically defined coronary artery disease. The tests of fibrinolysis were not related to the severity of coronary artery disease, as indicated either by the number of vessels involved or by a coronary score system. Fibrinogen levels, however, did show a modest association with the extent of coronary atheroma (r = 0.21, p < 0.05). Triglyceride levels were associated with the inhibitors of fibrinolysis: positively with α₂-antiplasmin (r = 0.31, p < 0.005) and negatively with α₂-macroglobulin (r = -0.25, p < 0.05). The α₂-antiplasmin levels were significantly elevated in patients with hypertriglyceridaemia. Neither smoking nor β-blockade had any effect on the tests of fibrinolysis. This study adds support to the association of plasma fibrinogen with ischaemic heart disease.

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Fibrinolytic Activity and Coronary-Artery Disease

Cited by 131 publications

References 17 publications

Trends in coronary artery disease and associated risk factors in sub-Saharan Africans

Trends in coronary artery disease and associated risk factors in sub-Saharan Africans

Role of Plasminogen Activator Inhibitor Type 1 in the Pathogenesis of Coronary Artery Diseases

Severity of Coronary Artery Disease and Basal Fibrinolysis

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