Chronic lymphedema presents as interstitial fluid retention due to a failure in the
lymphatic system drainage. The affected region becomes more vulnerable
immunologically and predisposed to the onset of neoplasms. Basal Cell Carcinoma is
the most common sort of neoplasm, nevertheless it rarely metastisizes. Sarcomas are
malignant mesenchymal neoplasms, locally aggressive, which can spread. Here is
reported an infrequent case of multiple basal cell carcinoma, synchronous to a poorly
differentiated pleomorphic sarcoma, both spreading to lymph nodes and arising from
tissue compromised by chronic lymphedema.