Fibroblast growth factor 21 Ameliorates diabetes-induced endothelial dysfunction in mouse aorta via activation of the CaMKK2/AMPKα signaling pathway

Lei, Ying; Li, Na; He, Zhengyue; Zeng, Xiangqiong; Ye, Nan; Chen, Jiantong; Miao, Peipei; Ying, Yunyun; Lin, Weihong; Zhao, Xinyu; Lu, Lu; Chen, Mengke; Cen, Wei; Guo, Tonglin; Li, Xiaokun; Huang, Zhifeng; Wang, Yang

doi:10.1038/s41419-019-1893-6

Cited by 47 publications

(42 citation statements)

References 50 publications

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“…Oxidative stress leads to the generation of reactive oxygen species (ROS) and/or down regulation of the body's innate antioxidant defence systems. 25 Reports also suggests that FGF21 plays a vital role in the prevention of atherosclerosis. 24 The stimulation of antioxidative pathways by FGF21 reduced the oxidative stress in cardiomyocytes and prevented injury.…”

Section: Discussionmentioning

confidence: 99%

Association of fibroblast growth factor 21 with oxidative stress and lipid profile in type 2 diabetes

et al. 2020

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Background: Cardiovascular disease is the most prevalent cause of morbidity and mortality in diabetic patients. Fibroblast growth factor 21 (FBG 21) is an endocrine factor that regulates glucose and lipid metabolism, insulin resistance, and obesity. Blood levels of FGF21 are elevated in patients with atherosclerosis, macrovascular, and microvascular complications of diabetes, possibly due to a compensatory up regulation. Studies reported that FGF21 is an important regulator of mitochondrial and oxidative stress. The role of FGF21 in chronic diseases and the diminished oxidative stress observed with anti-diabetic therapy has been the target of new studies. Current study aimed to evaluate serum FGF21 levels and its association with oxidative stress and lipid profile levels in type 2 diabetic patients.Methods: 100 controls and 100 diabetic patients on oral hypoglycemic drugs between 35-55 years of age without any cardiac, renal, liver, and thyroid dysfunction were selected for this study. Oxidative stress (MDA), total antioxidant status (FRAP), and FGF21 were measured. FGF21 was analyzed by ELISA methods. Serum MDA was assessed by the method of Yagi serum total antioxidant status was measured by the method of Benzie et al.Results: FGF21 level was increased in diabetic patients compared with controls. There was a significant positive correlation of FGF21 with MDA (r=0.875, p<0.01) and negative correlation with FRAP observed (r= -0.867 p<0.01). There was also positive correlation of FGF21 with total cholesterol (r=0.499, p<0.01), triglycerides (r=0.648, p<0.01), LDL-cholesterol (r=0.337, p<0.01) and negative correlation with HDL-cholesterol (r= -0.172, p<0.05) were observed.Conclusions: Increased oxidative stress and decreased antioxidant status were observed in diabetics. This could be due to dyslipidemia and increased generation of free radicals. High levels of FGF21 observed in our study might represent its resistant state and the compensatory response to maintain metabolic homeostasis. Further studies are needed to explore the role of FGF21 as a novel marker in predicting cardiovascular risk in diabetic patients.

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Section: Discussionmentioning

confidence: 99%

Association of fibroblast growth factor 21 with oxidative stress and lipid profile in type 2 diabetes

et al. 2020

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“…In rats with atherosclerosis, FGF-21 decreases inflammation by increasing the signalling of nuclear factor erythroid 2-related factor 2 (Nrf2)-antioxidant response elements (ARE) and by reducing the expression of NF-κB [ 334 , 335 ]. In diabetic mice, FGF-21 ameliorates endothelial dysfunction by suppressing oxidative stress and enhancing endothelium-dependent vasorelaxation through the activation of calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2)/protein kinase AMP-activated catalytic subunit alpha (AMPKα) [ 336 ].…”

Section: Role Of Some Adipokines In Inflammatory Processes Associamentioning

confidence: 99%

Adipokines and Inflammation: Focus on Cardiovascular Diseases

Feijóo‐Bandín

Aragón-Herrera

Moraña-Fernández

et al. 2020

IJMS

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It is well established that adipose tissue, apart from its energy storage function, acts as an endocrine organ that produces and secretes a number of bioactive substances, including hormones commonly known as adipokines. Obesity is a major risk factor for the development of cardiovascular diseases, mainly due to a low grade of inflammation and the excessive fat accumulation produced in this state. The adipose tissue dysfunction in obesity leads to an aberrant release of adipokines, some of them with direct cardiovascular and inflammatory regulatory functions. Inflammation is a common link between obesity and cardiovascular diseases, so this review will summarise the role of the main adipokines implicated in the regulation of the inflammatory processes occurring under the scenario of cardiovascular diseases.

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“…Such diseases have farreaching consequences. (29)(30)(31)(32)(33) It is also important to integrate endocrine and cytokine systems and to detect whether inflammatory factors contribute to the development of obesity as well as MetS or not.…”

Section: Resultsmentioning

confidence: 99%

Morbi̇d Obez Ve Metaboli̇k Sendromlu Çocuklarda Yeni̇ Nesi̇l Enflamatuvar Beli̇rteçleri̇n Değerlendi̇ri̇lmesi̇

Donma¹,

Erselcan²,

Yılmaz³

et al. 2020

Namık Kemal Tıp Dergisi

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Technological advancements, unbalanced nutrition, sedentary life style, are important factors in obesity. Obesity-inflammation relationis beingexamined. In this study, the relationships among new generation inflammatory markers in children with normal body mass index (C) as well as obese (OB), morbid obese (MO) children and those with metabolic syndrome (MetS) were investigated. Materials and Methods: A total of 172 children participated in the study.Group 1 comprised children with normal body-mass index (control group) (C). Obese (OB) children were in Group 2, MO children constituted Group 3 and Group 4 included MO children with MetS. The number of cases were 37, 34, 51 and 50 in groups 1, 2, 3 and 4, respectively. Anthropometric measurements were recorded. Serum spexin, adropin, adipolipin, fibroblast growth factor-21 and fetuin-A levels were determined. Statistical analyses were performed. Result: Spexin and adipolin levels were significantly lower in obese groups than C group (p<0.05). Although adropin and FGF-21 levels did not differ significantly between groups, levels were lower in OB, MO, and MetS groups than C group.There were no significant differences among fetuin-A levels of the groups. Correlations between spexin and adipolin were the highest. These cytokines were negatively correlated with obesity parameters. The correlations between these cytokines were weakened from C group to MetS group. Conclusion: Decreasing spexin and adipolin levels in accordance with increasing obesity degrees and weakening of the correlation between these cytokines in MO group compared to C group may be helpful during the further investigation of obesity.

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Fibroblast growth factor 21 Ameliorates diabetes-induced endothelial dysfunction in mouse aorta via activation of the CaMKK2/AMPKα signaling pathway

Cited by 47 publications

References 50 publications

Association of fibroblast growth factor 21 with oxidative stress and lipid profile in type 2 diabetes

Association of fibroblast growth factor 21 with oxidative stress and lipid profile in type 2 diabetes

Adipokines and Inflammation: Focus on Cardiovascular Diseases

Morbi̇d Obez Ve Metaboli̇k Sendromlu Çocuklarda Yeni̇ Nesi̇l Enflamatuvar Beli̇rteçleri̇n Değerlendi̇ri̇lmesi̇

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