Fibroblast growth factor 21 association with subclinical atherosclerosis and arterial stiffness in type 2 diabetes

Yafei, Saeed; Elsewy, Fathy; Youssef, Eman; Ayman, Mohammed; Elshafei, Mohamed

doi:10.1016/j.dsx.2018.12.007

Cited by 19 publications

(22 citation statements)

References 40 publications

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“…In EAT from T2DM patients with multivessel CAD, FGF-21 gene expression is reduced [ 317 ], and in patients undergoing cardiac surgery, FGF-21 expression in EAT increases after surgery, suggesting a role protecting from surgery-related inflammatory response [ 319 ]. However, several studies have shown that increased levels of circulating FGF-21 are associated with the presence of atherosclerosis [ 337 , 338 , 339 , 340 , 341 ], although there are contradictory results [ 342 ].…”

Section: Role Of Some Adipokines In Inflammatory Processes Associamentioning

confidence: 99%

Adipokines and Inflammation: Focus on Cardiovascular Diseases

Feijóo‐Bandín

Aragón-Herrera

Moraña-Fernández

et al. 2020

IJMS

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It is well established that adipose tissue, apart from its energy storage function, acts as an endocrine organ that produces and secretes a number of bioactive substances, including hormones commonly known as adipokines. Obesity is a major risk factor for the development of cardiovascular diseases, mainly due to a low grade of inflammation and the excessive fat accumulation produced in this state. The adipose tissue dysfunction in obesity leads to an aberrant release of adipokines, some of them with direct cardiovascular and inflammatory regulatory functions. Inflammation is a common link between obesity and cardiovascular diseases, so this review will summarise the role of the main adipokines implicated in the regulation of the inflammatory processes occurring under the scenario of cardiovascular diseases.

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Section: Role Of Some Adipokines In Inflammatory Processes Associamentioning

confidence: 99%

Adipokines and Inflammation: Focus on Cardiovascular Diseases

Feijóo‐Bandín

Aragón-Herrera

Moraña-Fernández

et al. 2020

IJMS

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“…Administration of FGF21 also protected against oxidative stress in human endothelial cells, supporting the antioxidative role of FGF21 in improving PWV [15]. The positive associations of FGF21 with arterial stiffness in male and female patients on haemodialysis [12] and patients with type 2 diabetes [13], and in obese women [37], could also suggest the compensatory antioxidative effects of FGF21 on increasing arterial stiffness. Collectively, these earlier results support the role of FGF21 in mediating an age-associated increase in arterial stiffness by decreasing oxidative stress.…”

Section: Discussionmentioning

confidence: 77%

“…However, people with cardiovascular diseases have increased resting concentrations of circulating FGF21 [11], suggesting either a compensatory cardioprotective effect of FGF21 or FGF21 resistance in cardiovascular disease states. FGF21 concentration is positively associated with carotid intima-media thickness and PWV in patients on haemodialysis [12] and patients with type 2 diabetes [13]. These results imply a potential link between FGF21 and arterial stiffness, possibly through the moderation of oxidative stress.…”

Section: Introductionmentioning

confidence: 77%

Pulse Wave Velocity Is Associated with Increased Plasma oxLDL in Ageing but Not with FGF21 and Habitual Exercise

Lee

Burns

et al. 2020

Antioxidants

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Fibroblast growth factor 21 (FGF21) and adiponectin increase the expression of genes involved in antioxidant pathways, but their roles in mediating oxidative stress and arterial stiffness with ageing and habitual exercise remain unknown. We explored the role of the FGF21–adiponectin axis in mediating oxidative stress and arterial stiffness with ageing and habitual exercise. Eighty age- and sex-matched healthy individuals were assigned to younger sedentary or active (18–36 years old, n = 20 each) and older sedentary or active (45–80 years old, n = 20 each) groups. Arterial stiffness was measured indirectly using pulse wave velocity (PWV). Fasted plasma concentrations of FGF21, adiponectin and oxidized low-density lipoprotein (oxLDL) were measured. PWV was 0.2-fold higher and oxLDL concentration was 25.6% higher (both p < 0.001) in older than younger adults, despite no difference in FGF21 concentration (p = 0.097) between age groups. PWV (p = 0.09) and oxLDL concentration (p = 0.275) did not differ between activity groups but FGF21 concentration was 9% lower in active than sedentary individuals (p = 0.011). Adiponectin concentration did not differ by age (p = 0.642) or exercise habits (p = 0.821). In conclusion, age, but not habitual exercise, was associated with higher oxidative stress and arterial stiffness. FGF21 and adiponectin did not differ between younger and older adults, meaning that it is unlikely that they mediate oxidative stress and arterial stiffness in healthy adults.

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“…These pathologic changes are postulated to be mechanisms for the subclinical atherosclerosis (initiation stage of atherosclerosis) ( 63 ). It is reported that elevated serum level of FGF21 was related to atherosclerosis in subjects with DM ( 12 , 14 , 15 , 64 ), suggesting FGF21 resistance and/or a compensatory mechanism in response to DM. Yan et al found that deletion of FGF21 in diabetic mice could worsen DM-induced cell apoptosis and aortic remodeling by aggravating aortic oxidative stress and inflammation, while the pathologic changes caused by FGF21 knockout was reversed by exogenous FGF21 administration in diabetic mice ( 17 ).…”

Section: Fgf21 and Diabetic Vascular Complicationsmentioning

confidence: 99%

“…For example, high serum level of endogenous FGF21 is considered as a compensatory response to ameliorate atherosclerotic diseases or represents the resistant state of FGF21 (7,9), while treatment with exogenous FGF21 could protect against atherosclerosis (10). Particularly, several lines of evidences indicate a close and complicated relationship between DMinduced cardiovascular complications and FGF21 (11)(12)(13). Studies have shown that the early compensatory serum high level of FGF21 is responsive to the occurrence and development of DM-induced cardiovascular complications (14,15).…”

Section: Introductionmentioning

confidence: 99%

The Role of Fibroblast Growth Factor 21 in Diabetic Cardiovascular Complications and Related Epigenetic Mechanisms

et al. 2021

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Fibroblast growth factor 21 (FGF21), is an emerging metabolic regulator mediates multiple beneficial effects in the treatment of metabolic disorders and related complications. Recent studies showed that FGF21 acts as an important inhibitor in the onset and progression of cardiovascular complications of diabetes mellitus (DM). Furthermore, evidences discussed so far demonstrate that epigenetic modifications exert a crucial role in the initiation and development of DM-related cardiovascular complications. Thus, epigenetic modifications may involve in the function of FGF21 on DM-induced cardiovascular complications. Therefore, this review mainly interprets and delineates the recent advances of role of FGF21 in DM cardiovascular complications. Then, the possible changes of epigenetics related to the role of FGF21 on DM-induced cardiovascular complications are discussed. Thus, this article not only implies deeper understanding of the pathological mechanism of DM-related cardiovascular complications, but also provides the possible novel therapeutic strategy for DM-induced cardiovascular complications by targeting FGF21 and related epigenetic mechanism.

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Fibroblast growth factor 21 association with subclinical atherosclerosis and arterial stiffness in type 2 diabetes

Cited by 19 publications

References 40 publications

Adipokines and Inflammation: Focus on Cardiovascular Diseases

Adipokines and Inflammation: Focus on Cardiovascular Diseases

Pulse Wave Velocity Is Associated with Increased Plasma oxLDL in Ageing but Not with FGF21 and Habitual Exercise

The Role of Fibroblast Growth Factor 21 in Diabetic Cardiovascular Complications and Related Epigenetic Mechanisms

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