Fibroblast growth factor 21 in cardio-metabolic disorders: a systematic review and meta-analysis

Lakhani, Ishan; Gong, Mengqi; Wong, Wing Tak; Bazoukis, George; Λαμπρόπουλος, Κωνσταντίνος; Wong, Sunny H.; Wu, William Ka Kei; Wong, Martin Cs; Ong, Kwok-Leung; Liu, Tong; Tse, Gary

doi:10.1016/j.metabol.2018.01.017

Cited by 56 publications

(36 citation statements)

References 53 publications

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“…FGF21 levels are reasonably stable and do not vary significantly after repetitive freeze-thaw cycles. 51,52 Several studies have revealed that serum FGF21 levels are independently associated with metabolic disturbances, and that high levels of FGF21 predict impaired glucose metabolism. 49,50 This rhythm of FGF21 release aligns with the hypothesis that FGF21 is an important metabolic regulator that integrates with the circadian rhythm of energy homoeostasis in humans.…”

Section: Circul Ating Fg F21 Le Vel Smentioning

confidence: 99%

“…49 FGF21 levels correlate with different cardiometabolic conditions, and higher FGF21 levels are associated with cardiovascular disease risk factors such as chronic inflammation, obesity, hypertriglyceridaemia and elevated liver enzyme levels. 51,52 Several studies have revealed that serum FGF21 levels are independently associated with metabolic disturbances, and that high levels of FGF21 predict impaired glucose metabolism. 53…”

Section: Circul Ating Fg F21 Le Vel Smentioning

confidence: 99%

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Role of fibroblast growth factor 21 in gestational diabetes mellitus: A mini‐review

Yuan

Henry

et al. 2018

Clinical Endocrinology

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Gestational diabetes mellitus (GDM) is defined as glucose intolerance with onset or first diagnosis during pregnancy, but not to the level of being diagnostic for diabetes in a nonpregnant adult. 1 During pregnancy, maternal tissues become progressively insensitive to insulin due to metabolic changes that ensure adequate nutrition is supplied to the foetus. 2,3 One such change is that insulin-mediated whole-body glucose disposal decreases by 40%-60%, necessitating a 200%-250% increase in insulin secretion in order to maintain a normal blood glucose concentration. 4 GDM develops when a pregnant woman does not produce enough insulin to compensate for this insulin resistance. 2 GDM is a serious, common complication in pregnancy, threatening the health of one in every 7 pregnant women globally, their foetuses and newborns. 5-8 It increases the risk of maternal hypertensive disorders of pregnancy, foetal macrosomia, caesarean section, traumatic injury at birth for both mother and baby and other adverse pregnancy outcomes. 6,7,9 Moreover, GDM is also associated Abstract Gestational diabetes mellitus (GDM) is defined as glucose intolerance with onset or first diagnosis during pregnancy, but not to the level of being diagnostic for diabetes in a nonpregnant adult. In GDM, whole-body insulin-dependent glucose disposal decreases by 40%-60% which necessitates a 200%-250% increase in insulin secretion to maintain normoglycaemia. GDM develops when a pregnant woman does not produce sufficient insulin to compensate for the reduced glucose disposal. Fibroblast

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Section: Circul Ating Fg F21 Le Vel Smentioning

confidence: 99%

Section: Circul Ating Fg F21 Le Vel Smentioning

confidence: 99%

Role of fibroblast growth factor 21 in gestational diabetes mellitus: A mini‐review

Yuan

Henry

et al. 2018

Clinical Endocrinology

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“…Obese individuals manifest endocrine resistance, which is characterized by an abnormally high concentration of a circulating hormone, and endocrine resistance is an independent risk factor of some diseases, as is the case for insulin resistance (29). Chronically elevated levels of circulating FGF21 are a predictive factor of metabolic diseases (5,6,8), and FGF21 resistance is observed in obese individuals (3) who have an attenuated fasting-induced increase in circulating FGF21 levels (12). In the present study, mice with diet-induced fatty liver showed increased and reduced plasma FGF21 levels during the dark/feeding and light/fasting periods, respectively, whereas the abnormal FGF21 secretion was prevented in non-fatty-liver mice fed soy protein-rich diets.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, it seems likely that elevated levels of circulating FGF21 are associated with leanness, but in contrast, previous studies have shown that obese patients have a higher circulating FGF21 concentration (3). The increased FGF21 levels are thought to represent an FGF21-resistant state (4), and the chronically high levels of circulating FGF21 are associated with the onset of type 2 diabetes (5,6), metabolic syndrome (6,7), and cardiovascular diseases (8).…”

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confidence: 99%

Hepatic Fat Content Is Associated with Fasting-Induced Fibroblast Growth Factor 21 Secretion in Mice Fed Soy Proteins

Taniguchi

Akiyama

Ishihara

2019

J Nutr Sci Vitaminol

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Previous studies suggest that circulating fibroblast growth factor 21 (FGF21) levels are elevated in patients with fatty liver, while fasting-induced secretion of FGF21 is lower in obese patients. It has been reported that soy protein prevents hepatic fat accumulation and induces FGF21 secretion. The present study was designed to evaluate the response of circulating FGF21 levels to feeding and fasting in mice fed soy protein-rich diets. For this, C57BL/6J mice were distributed into control, high-fat high-sucrose (HFHS)-casein protein, HFHS-soy protein, and HFHS-b-conglycinin diet groups. Plasma samples were collected after 10 and 11 wk either in dark periods with feeding conditions or light periods under fasting conditions using a crossover design. After a 12-wk period of feeding, HFHS-induced hepatic fat accumulation was significantly reduced in the groups fed HFHS-soy protein and HFHS-b-conglycinin as compared to that in the HFHS-casein-fed group (p,0.05). Plasma FGF21 concentration was significantly higher in the dark/feeding periods in the HFHScasein group (p,0.05), while in the HFHS-b-conglycinin group it was higher in the light/ fasting periods (p,0.05). The amount of mesenteric fat was significantly lower in the HFHSb-conglycinin group than in the HFHS-casein and HFHS-soy protein groups (p,0.01). The fasting-induced FGF21 secretion was significantly and negatively correlated with hepatic fat content (p,0.05). The present study revealed that hepatic fat accumulation was associated with lower fasting-induced FGF21 secretion, which was regulated better by dietary intake of soy protein. These results support the preventive effects of soy protein on central obesity.

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“…Fibroblast growth factor 21 (FGF21) is a novel hormone that is predictive of cardio-metabolic disorders [9]. FGF21 protects against cardiac hypertrophy, cardiac dilation and cardiac dysfunction in animal models [10].…”

Section: Introductionmentioning

confidence: 99%

Pulse Wave Velocity Is Associated with Increased Plasma oxLDL in Ageing but Not with FGF21 and Habitual Exercise

Lee

Burns

et al. 2020

Antioxidants

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Fibroblast growth factor 21 (FGF21) and adiponectin increase the expression of genes involved in antioxidant pathways, but their roles in mediating oxidative stress and arterial stiffness with ageing and habitual exercise remain unknown. We explored the role of the FGF21–adiponectin axis in mediating oxidative stress and arterial stiffness with ageing and habitual exercise. Eighty age- and sex-matched healthy individuals were assigned to younger sedentary or active (18–36 years old, n = 20 each) and older sedentary or active (45–80 years old, n = 20 each) groups. Arterial stiffness was measured indirectly using pulse wave velocity (PWV). Fasted plasma concentrations of FGF21, adiponectin and oxidized low-density lipoprotein (oxLDL) were measured. PWV was 0.2-fold higher and oxLDL concentration was 25.6% higher (both p < 0.001) in older than younger adults, despite no difference in FGF21 concentration (p = 0.097) between age groups. PWV (p = 0.09) and oxLDL concentration (p = 0.275) did not differ between activity groups but FGF21 concentration was 9% lower in active than sedentary individuals (p = 0.011). Adiponectin concentration did not differ by age (p = 0.642) or exercise habits (p = 0.821). In conclusion, age, but not habitual exercise, was associated with higher oxidative stress and arterial stiffness. FGF21 and adiponectin did not differ between younger and older adults, meaning that it is unlikely that they mediate oxidative stress and arterial stiffness in healthy adults.

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Fibroblast growth factor 21 in cardio-metabolic disorders: a systematic review and meta-analysis

Cited by 56 publications

References 53 publications

Role of fibroblast growth factor 21 in gestational diabetes mellitus: A mini‐review

Role of fibroblast growth factor 21 in gestational diabetes mellitus: A mini‐review

Hepatic Fat Content Is Associated with Fasting-Induced Fibroblast Growth Factor 21 Secretion in Mice Fed Soy Proteins

Pulse Wave Velocity Is Associated with Increased Plasma oxLDL in Ageing but Not with FGF21 and Habitual Exercise

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