Fibrocartilaginous mesenchymoma of the spine in a child: a case report

Martínez‐Lage, Juan F.; Alarcón, Fernando; Hernández-Barceló, José E.; Almagro, María-José; Alfaro, Raúl; Galera, Ana María

doi:10.1007/s00381-009-1042-0

Cited by 10 publications

(25 citation statements)

References 12 publications

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“…Our patient's other potential diagnosis, fibrocartilaginous mesenchymoma, is a benign locally aggressive bone tumor of children and adolescents; to the best of our knowledge, only twenty cases have been reported in the literature 1,4,5,8 . It was first described in 1984 when Dahlin et al reported five cases of a previously unrecognized bone neoplasm that was called fibrocartilaginous mesenchymoma with low-grade malignancy 4,5,15 .…”

Section: Discussionmentioning

confidence: 83%

“…Radiographs demonstrated a predominantly osteolytic metaphyseal lesion with focal mineralization, which characterizes this lesion 1 . Intraoperative biopsy revealed a lesion with predominantly chondroid matrix, which was admixed with trabecular bone, and a bland-to-hypercellular fibrous stroma showing sparse polymorphism without mitotic figures, all of which are characteristic of this lesion; the diagnosis was supported by later confirmation of the GNAS mutation by polymerase chain reaction 6,8,9 . Described treatments for fibrocartilaginous dysplasia include observation, curettage with bone-grafting, intramedullary nailing, and en bloc excision 1,5,10-12 .…”

Section: Discussionmentioning

confidence: 86%

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Fibrocartilaginous Dysplasia of the Proximal Part of the Femur with a Pathological Fracture in a Child

Henderson

Monforte²,

Neustadt³

2014

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Section: Discussionmentioning

confidence: 83%

Section: Discussionmentioning

confidence: 86%

Fibrocartilaginous Dysplasia of the Proximal Part of the Femur with a Pathological Fracture in a Child

Henderson

Monforte²,

Neustadt³

2014

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“…El diagnóstico diferencial incluye lesiones benignas, como el quiste óseo simple, quiste óseo aneurismático, histiocitosis, displasia fibrocartilaginosa (DFC), displasia fibrosa, fibroma desmoplásico, quiste óseo aneurismático, fibroma condromixoide, condroblastoma y tumor de células gigantes. 7,8,11 A l g u n a s l e s i o n e s m a l i g n a s , c o m o e l condrosarcoma, osteosarcoma de bajo grado, fibrosarcoma y sarcoma de Ewing, también deben ser consideradas. 4,11 El principal diagnóstico diferencial del mesenquimoma fibrocartilaginoso es la displasia fibrocartilaginosa.…”

Section: Discussionunclassified

“…7,8,11 A l g u n a s l e s i o n e s m a l i g n a s , c o m o e l condrosarcoma, osteosarcoma de bajo grado, fibrosarcoma y sarcoma de Ewing, también deben ser consideradas. 4,11 El principal diagnóstico diferencial del mesenquimoma fibrocartilaginoso es la displasia fibrocartilaginosa. Ambas lesiones presentan características clínicas, radiológicas e histopatológicas similares, e incluso algunos autores las consideran la misma entidad.…”

Section: Discussionunclassified

“…Desde su descripción original por Dahlin y cols., en 1984, 2 se han reportado poco más de 20 casos. [3][4][5][6][7][8][9][10][11][12][13][14][15] El objetivo de este trabajo es comunicar un caso adicional de mesenquimoma fibrocartilaginoso en un paciente pediátrico. Se solicitó consentimiento escrito a la familia del paciente para la publicación del caso.…”

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Mesenquimoma fibrocartilaginoso de húmero proximal: reporte de un caso

2014

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Presentación de casos clínicos RESUMENEl mesenquimoma fibrocartilaginoso (MFC) es un tumor raro, que afecta principalmente a los huesos largos. Se han reportado pocos casos desde su descripción. Presentamos un caso de un niño de 4 años de edad con MFC situado en el húmero. Las radiografías mostraron una lesión lítica expansiva situada en la región metafisaria del húmero proximal. La resonancia magnética objetivó expansión del tumor a partes blandas. La anatomía patológica fue confirmatoria de MFC. El paciente fue tratado con curetaje, fenolización adyuvante y sustituto óseo mezclado con aspirado de médula ósea. A los dos años de seguimiento, no se evidenció recidiva. El MFC debe ser tenido en cuenta entre los diagnósticos diferenciales en lesiones óseas líticas en niños y adolescentes. Palabras clave: mesenquimoma fibrocartilaginoso, displasia fibrocartilaginosa, tumor, niño. Diseño del estudio: reporte de caso (nivel de evidencia IV). ABSTRACTFibrocartilaginous mesenchymoma (FCM) is a rare tumor that primarily affects the long bones. Few cases have been reported since its description. A case of a 4-year-old boy with FCM located in the humerus is presented. Radiological examination showed an expansive lytic lesion located in the metaphyseal proximal humerus. Magnetic resonance imaging showed soft tissue expansion. Histopathological diagnosis was confirmatory of FCM. Curettage, adjuvant phenolization, and bone grafting with bone substitute, and autologous bone marrow was performed. During a follow-up period of 2 years, there was no evidence of disease progression. FCM should be considered in the differential diagnosis of lytic bone lesions in children and adolescents.

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Fibrocartilaginous mesenchymoma, a unique osseous lesion: case report with review of the literature

et al. 2011

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Fibrocartilaginous mesenchymoma is a rare osseous tumor that primarily arises in the long bones of children and adolescents. This lesion can grow quickly and reach a considerable size, despite its benign nature. It has proved challenging to diagnose and can be mistaken for a spectrum of benign and malignant bone tumors. The histological presentation of unique epiphyseal plate-like cartilage with destruction of the surrounding cortical bone and exhibition of dense fibrous stroma are important indicators for the diagnosis of fibrocartilaginous mesenchymoma. An 11-year-old boy presented with a left proximal humerus mass thought to be an aneurysmal bone cyst. The patient was lost to follow-up and came back 3 years later with massive growth of the lesion. Owing to the aggressive nature of the tumor, a left forequarter amputation was performed. Histological examination demonstrated numerous islands of cartilage with an exuberant spindle cell component characteristic of FCM. No distant metastases or local recurrences were identified at 2 years post-amputation. Because of the rapid growth of this lesion, it should be considered in the differential diagnosis of bone lesions in children and young adults.

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Fibrocartilaginous mesenchymoma of the spine in a child: a case report

Abstract: Given the rarity of spinal FCM, there are no guidelines about its management. However, treatment of this neoplasm seems to be mainly surgical aiming at total removal of the lesion, if feasible, as FCM may recur locally.

Cited by 10 publications

References 12 publications

Fibrocartilaginous Dysplasia of the Proximal Part of the Femur with a Pathological Fracture in a Child

Fibrocartilaginous Dysplasia of the Proximal Part of the Femur with a Pathological Fracture in a Child

Mesenquimoma fibrocartilaginoso de húmero proximal: reporte de un caso

Fibrocartilaginous mesenchymoma, a unique osseous lesion: case report with review of the literature

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