Fibrocytes contribute to the myofibroblast population in wounded skin and originate from the bone marrow

Mori, Luisa; Bellini, Alberto; Stacey, Martin; Schmidt, Matthias; Mattoli, Sabrina

doi:10.1016/j.yexcr.2004.11.011

Cited by 342 publications

(327 citation statements)

References 17 publications

(44 reference statements)

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“…Several studies have suggested that CD34 -positive cells may be bone marrow-derived hematopoietic cells that could be undergoing a vasculogenic transformation to form new vessels or to incorporate into newly forming vessels [15]. cKit-positive-mesenchymal progenitor cells originating from bone marrow could be differentiated into fibroblastic cells, and may contribute to corneal wound healing [5,13,16].…”

Section: Discussionmentioning

confidence: 99%

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Bone marrow-derived progenitor cells promote corneal wound healing following alkali injury

Lee

Kook

et al. 2007

Graefes Arch Clin Exp Ophthalmol

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Section: Discussionmentioning

confidence: 99%

“…Bone marrow is now recognized as a source of progenitor cells for several cell types, including epithelial cells, [4] fibroblasts, [5] endothelial cells, [6] and neurons [7]. In addition to hematopoietic progenitor cells, bone marrow contains a second type of progenitor cells, termed mesen-chymal progenitor cells.…”

Section: Introductionmentioning

confidence: 99%

Bone marrow-derived progenitor cells promote corneal wound healing following alkali injury

Lee

Kook

et al. 2007

Graefes Arch Clin Exp Ophthalmol

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“…121 Similar to fibroblasts in morphology, their haematopoietic origin is confirmed by the expression of CD11b, CD13, CD34, and CD45 markers. 122,123 They have a multifunctional role that includes the secretion of cytokines, growth factors and chemokines, the promotion of angiogenesis, the synthesis of collagen and fibronectin, and are involved in scar tissue contraction and remodelling through MMP production. 122,124 In pathological repair, bone marrowderived peripheral blood mononuclear cells more readily differentiate to fibrocytes whereas the fibrotic tissue itself contains more of these cells than the normal scar tissue.…”

Section: Subretinal Neovascularisationmentioning

confidence: 99%

“…122,123 They have a multifunctional role that includes the secretion of cytokines, growth factors and chemokines, the promotion of angiogenesis, the synthesis of collagen and fibronectin, and are involved in scar tissue contraction and remodelling through MMP production. 122,124 In pathological repair, bone marrowderived peripheral blood mononuclear cells more readily differentiate to fibrocytes whereas the fibrotic tissue itself contains more of these cells than the normal scar tissue. 125 Finally, fibrocytes can act as precursors of fibroblasts, which can also be involved in aberrant scarring.…”

Section: Subretinal Neovascularisationmentioning

confidence: 99%

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The stereotypical molecular cascade in neovascular age-related macular degeneration: the role of dynamic reciprocity

Kent

2015

Eye

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This review summarises our current understanding of the molecular basis of subretinal neovascularisation (SRNV) in age-related macular degeneration (AMD). The term neovascular AMD (NVAMD) is derived from the dominant early clinical features of haemorrhage, fluid, and lipid in the subretinal space (SRS) and the historical role of fluorescein angiography in detecting the presence of NV tissue. However, at the cellular level, SRNV resembles an aberrant but stereotypical tissue repair response that incorporates both an early inflammatory phase and a late fibrotic phase in addition to the neovascular (NV) component that dominates the early clinical presentation. This review will seek not only to highlight the important molecules involved in each of these components but to demonstrate that the development of SRNV has its origins in the earliest events in non-NV AMD pathogenesis. Current evidence suggests that this early-stage pathogenesis is characterised by complementmediated immune dysregulation, leading to a state of chronic inflammation in the retinal pigment epithelium/Bruch's membrane/ choriocapillaris complex. These initial events can be seamlessly and inextricably linked to late-stage development of SRNV in AMD by the process of dynamic reciprocity (DyR), the ongoing bidirectional communication between cells, and their surrounding matrix. Moreover, this correlation between disease onset and eventual outcome is reflected in the temporal and spatial correlation between chronic inflammation, NV, and fibrosis within the reparative microenvironment of the SRS. In summary, the downstream consequences of the earliest dysfunctional molecular events in AMD can result in the late-stage entity we recognize clinically as SRNV and is characterized by a spectrum of predictable, related, and stereotypical processes referred to as DyR.

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Anatomy of the Dental/Alveolar Structures and Wound Healing

Price¹

2020

Practical Advanced Periodontal Surgery

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Fibrocytes contribute to the myofibroblast population in wounded skin and originate from the bone marrow

Cited by 342 publications

References 17 publications

Bone marrow-derived progenitor cells promote corneal wound healing following alkali injury

Bone marrow-derived progenitor cells promote corneal wound healing following alkali injury

The stereotypical molecular cascade in neovascular age-related macular degeneration: the role of dynamic reciprocity

Anatomy of the Dental/Alveolar Structures and Wound Healing

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