Fibrodysplasia Ossificans Progressiva-like Condition in a Cat

Abstract

ABSTRACT. Fibrodysplasia ossificans progressiva (FOP)-like condition was diagnosed in a Japanese domestic cat with stiffness, marked atrophy of the muscles, and limited mobility of all joints in both the pelvic limbs. Etretinate, a retinoid, was used for medical management; however, no improvement in the clinical signs was observed. Inheritance of the disorder has not yet been demonstrated. Furthermore, the clinical signs and histopathological findings of feline FOP-like condition in the present case differed from those of the previously reported cases. KEY WORDS: feline, fibrodysplasia ossificans progressiva, heterotopic ossification.

Fibrodysplasia ossificans progressiva-like in a cat

“…The only relevant finding was an increase in serum creatine kinase activity, which corroborates other reports (Asano et al, 2006).…”

“…Differently from the cases of canines with FOPlike conditions (Guilliard, 2001), the disease has not been observed in older cats: the average age in the reports was 2.6 years (ranging from 10 months to 6 years) (Warren and Carpter, 1984;Asano et al, 2006;Yabuzoe et al, 2009). …”

“…Fibrodysplasia ossificans progressiva (FOP), also known as myositis ossificans progressiva or Münchmeyer's disease (Campos et al, 2005), is a rare disease in humans (Palhares and Leme, 2001) and animals (Guilliard, 2001;Kaplan et al, 2005;Asano et al, 2006).…”

“…Information about fibrodysplasia ossificans progressiva-like (FOP-like) in veterinary medicine is limited due to the small number of reports regarding the natural occurrence of ectopic ossification in animals (Guilliard, 2001;Kaplan et al, 2005;Asano et al, 2006). Based on the literature consulted, it was assumed that only eight cases of FOP-like conditions have been described in cats all over the world (Asano et al, 2006;Yabuzoe et al, 2009) …”

“…Based on the literature consulted, it was assumed that only eight cases of FOP-like conditions have been described in cats all over the world (Asano et al, 2006;Yabuzoe et al, 2009) …”