Fibroepithelioma‐like changes occurring in perianal Paget's disease with rectal mucinous carcinoma: case report and review of 49 cases of extramammary Paget's disease

Ishida‐Yamamoto, Akemi; Sato, Katsuhiko; Wada, Takashi; Takahashi, Hidetoshi; Toyota, Noriaki; Shibaki, Taiichiro; Yamazaki, Kiyohiro; Tokusashi, Yoshihiko; Miyokawa, Naoyuki; Iizuka, Hajime

doi:10.1034/j.1600-0560.2002.290311.x

Cited by 26 publications

(10 citation statements)

References 13 publications

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“…Two previous studies have shown that EMPD may be associated with a significant epidermal hyperplasia. 23,24 Immunohistochemical studies will be helpful by highlighting the expression in the tumor cells of antikeratin antibodies and other epithelial markers (carcinoembryonic antigen, epithelial membrane antigen, mucoproteins, etc) but not melanocytic markers (Mart-1 or HMB-45 antigen). However, due to some unexpected findings (such as S100 protein expression by some breast carcinoma cells or the apparent overexpression of Mart-1 by dysplastic keratinocytes in pigmented actinic keratoses), 25 the use of antibody panels are recommended to clearly determining the pattern of differentiation (that is, epithelial or melanocytic) of the tumor cells.…”

Section: Discussionmentioning

confidence: 99%

Pigmented Paget Disease - A Diagnostic Pitfall Mimicking Melanoma

Petersson¹,

Ivan²,

Kazakov³

et al. 2009

The American Journal of Dermatopathology

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Pigmented mammary and extramammary Paget disease are rare entities in both males and females that mimic melanoma both clinically and histologically. Furthermore, Paget disease can be associated with increased number of benign melanocytes, thus resulting in additional diagnostic difficulty, especially when only hematoxylin and eosin-stained sections are examined and a limited immunohistochemical study is performed. Using standard hematoxylin and eosin-stained sections and routine immunohistochemical studies, we describe and characterize 7 cases of pigmented extramammary and mammary Paget disease. In all cases, malignant epithelial cells showed intracytoplasmic pigment, along with an immunohistochemical epithelial phenotype. In 2 of the cases, immunohistochemistry revealed numerous dendritic processes positive for melanocytic markers, thus resulting in an initial diagnosis of melanoma. Careful analysis confirmed that the immunolabeling corresponded to cytoplasmic labeling of melanocyte dendrites surrounding tumor cells. The correct diagnosis of pigmented Paget disease can be reached after close histologic examination and detailed evaluation of immunohistochemical studies. The latter are especially important in some extraordinary cases in which there may be an associated intraepithelial melanocytic hyperplasia.

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Section: Discussionmentioning

confidence: 99%

Pigmented Paget Disease - A Diagnostic Pitfall Mimicking Melanoma

Petersson¹,

Ivan²,

Kazakov³

et al. 2009

The American Journal of Dermatopathology

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“…4), aldehyde‐fuchsin and toluidin blue. The epidermis is often hyperplastic, sometimes showing fibroepithelioma‐like changes 70 . Suprabasal intra‐epidermal acantholytic clefts may be found, mimicking Darier's disease or familial pemphigus.…”

Section: Extramammary Paget's Diseasementioning

confidence: 99%

Mammary and extramammary Paget's disease

Kanitakis

2007

Acad Dermatol Venereol

279

287

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Paget's disease is an intra-epidermal adenocarcinoma seen over the nipple/areola (mammary Paget's disease) or in extramammary body zones, such as the anogenital and perineal skin and the axilla. Mammary and extramammary Paget's disease share many common clinicopathological features but also show several differences, namely, with regard to pathogenesis and association with underlying malignancies. Indeed, mammary Paget's disease is as a rule associated with an underlying breast carcinoma whereas association of extramammary Paget's disease with underlying (skin or visceral) malignancies occurs much less frequently. We review here the main clinicopathological and therapeutic features of mammary and extramammary Paget's disease.

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“…However, although its significance remains unknown, the simultaneous occurrence of EMPD and other epidermal proliferative diseases has been reported [2, 3, 4, 5, 6, 7, 8]. Brainard and Hart [6]described the reactive proliferating epidermal lesions in anogenital EMPD and stressed the fact that EMPD might mimic condyloma acuminatum (CA), a human-papillomavirus (HPV)-associated epidermal neoplasm affecting the anogenital region [9].…”

Section: Introductionmentioning

confidence: 99%

Extramammary Paget’s Disease Not Only Mimicking but Also Accompanying Condyloma acuminatum

Honda

Egawa²

2005

Dermatology

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Although its significance remains unknown, it has recently been reported that epidermal papillomatous hyperplasia could be frequently found in extramammary Paget’s disease (EMPD). The simultaneous occurrence of EMPD and various human-papillomavirus (HPV)-associated neoplasms has also been reported. We report a case of a perianal EMPD with multiple verrucous papules on its surface. Histologically, the verrucous papules consisted of two distinct histological patterns; one showed numerous Paget’s cells within the hyperplastic epidermis with papillomatosis, and the other showed the features compatible with condyloma acuminatum (CA). HPV-6 DNA was demonstrated in koilocytic keratinocytes of the CA by in situ hybridization. No positive signal was obtained for targeted HPV type 6/11/16/18/31/33 DNA in either the verrucous or plaque EMPD. Since the verrucous papules were localized on the plaque of EMPD, our case suggests that some undetermined EMPD-related factors may contribute to the development of epithelial hyperplasia, including HPV-associated neoplasms.

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Fibroepithelioma‐like changes occurring in perianal Paget's disease with rectal mucinous carcinoma: case report and review of 49 cases of extramammary Paget's disease

Abstract: Anogenital PD was more frequently associated with epidermal hyperplasia than axillary PD. Fibroepitheliomatous hyperplasia may be induced by the altered stroma associated with PD.

Cited by 26 publications

References 13 publications

Pigmented Paget Disease - A Diagnostic Pitfall Mimicking Melanoma

Pigmented Paget Disease - A Diagnostic Pitfall Mimicking Melanoma

Mammary and extramammary Paget's disease

Extramammary Paget’s Disease Not Only Mimicking but Also Accompanying Condyloma acuminatum

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